(S)-3-[(S)-2-((S)-1-ETHOXYCARBONYL-3-PHENYL-PROPYLAMINO)-PROPIONYL]-1-METHYL-2-OXO-IMIDAZOLIDINE-4-CARBOXYLIC ACID

Product Name: (S)-3-[(S)-2-((S)-1-ETHOXYCARBONYL-3-PHENYL-PROPYLAMINO)-PROPIONYL]-1-METHYL-2-OXO-IMIDAZOLIDINE-4-CARBOXYLIC ACID
CAS No.: 89396-94-1
Chemical Name: (S)-3-[(S)-2-((S)-1-ETHOXYCARBONYL-3-PHENYL-PROPYLAMINO)-PROPIONYL]-1-METHYL-2-OXO-IMIDAZOLIDINE-4-CARBOXYLIC ACID
Synonyms: TA 6366;Novaloc;SH-6366;Novarok;Tanapril;Tanatril;ACE/TA-6366;IMipadril HCl;Imidaprilhydrochloride;Imidapril HCl (TA-6366)
CBNumber: CB81009271
Molecular Formula: C20H27N3O6
Formula Weight: 405.44488
MOL File: 89396-94-1.mol

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(S)-3-[(S)-2-((S)-1-ETHOXYCARBONYL-3-PHENYL-PROPYLAMINO)-PROPIONYL]-1-METHYL-2-OXO-IMIDAZOLIDINE-4-CARBOXYLIC ACID Property

Melting point:: 214-216℃
alpha: D20 -64.1° (c = 0.5 in ethanol)
storage temp.: -20°C
solubility: H2O: ≥5mg/mL
form: powder
color: white to tan
optical activity: [α]/D -50 to -70° in ethanol (c=0.5)
Merck: 14,4911

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Safety

WGK Germany: 3
RTECS: NI8927400
HS Code: 2933.29.4300

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0148
Product name: Imidapril hydrochloride
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $77.4
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0148
Product name: Imidapril hydrochloride
Purity: ≥98% (HPLC)
Packaging: 50mg
Price: $505
Updated: 2024/03/01

TCI Chemical

Product number: I0901
Product name: Imidapril Hydrochloride
Purity: >98.0%(HPLC)(T)
Packaging: 25mg
Price: $126
Updated: 2024/03/01

TCI Chemical

Product number: I0901
Product name: Imidapril Hydrochloride
Purity: >98.0%(HPLC)(T)
Packaging: 100mg
Price: $343
Updated: 2024/03/01

Alfa Aesar

Product number: H37392
Product name: Imidapril (hydrochloride)
Purity: 98%
Packaging: 1g
Price: $437.65
Updated: 2024/03/01

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(S)-3-[(S)-2-((S)-1-ETHOXYCARBONYL-3-PHENYL-PROPYLAMINO)-PROPIONYL]-1-METHYL-2-OXO-IMIDAZOLIDINE-4-CARBOXYLIC ACID Chemical Properties,Usage,Production

Uses

Imidapril hydrochloride was used as a standard in bioequivalence test by LC/MS method.

Uses

Angiotensin converting enzyme (ACE) inhibitor. Antihypertensive.

Uses

antibiotic

Definition

ChEBI: Imidapril hydrochloride is a dipeptide.

General Description

Imidapril comprises large acyl moiety and is hydrolyzed by carboxylesterase (CES) 1.

Biochem/physiol Actions

Imidapril is a potent angiotensin converting enzyme inhibitor and anti-hypertensive.

Clinical Use

Angiotensin-converting enzyme inhibitor:

Hypertension

Drug interactions

Potentially hazardous interactions with other drugs
Anaesthetics: enhanced hypotensive effect.
Analgesics: antagonism of hypotensive effect and increased risk of renal impairment with NSAIDs; hyperkalaemia with ketorolac and other NSAIDs.
Antihypertensives: increased risk of hyperkalaemia, hypotension and renal failure with ARBs and aliskiren.
Bee venom extract: possible severe anaphylactoid reactions when used together.
Ciclosporin: increased risk of hyperkalaemia and nephrotoxicity.
Cytotoxics: increased risk of angioedema with everolimus.
Diuretics: enhanced hypotensive effect; hyperkalaemia with potassium-sparing diuretics.
ESAs: increased risk of hyperkalaemia; antagonism of hypotensive effect.
Gold: flushing and hypotension with sodium aurothiomalate.
Lithium: reduced excretion, possibility of enhanced lithium toxicity.
Potassium salts: increased risk of hyperkalaemia.
Tacrolimus: increased risk of hyperkalaemia and nephrotoxicity.

Metabolism

Imidapril is a prodrug, and is metabolised in the liver to the diacid imidaprilat, its active metabolite. The bioavailability of imidaprilat is about 42% after oral doses of imidapril.
About 40% of an oral dose is excreted in the urine, the rest in the faeces.

(S)-3-[(S)-2-((S)-1-ETHOXYCARBONYL-3-PHENYL-PROPYLAMINO)-PROPIONYL]-1-METHYL-2-OXO-IMIDAZOLIDINE-4-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-3-[(S)-2-((S)-1-ETHOXYCARBONYL-3-PHENYL-PROPYLAMINO)-PROPIONYL]-1-METHYL-2-OXO-IMIDAZOLIDINE-4-CARBOXYLIC ACID Suppliers

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TCI Chemicals (India) Pvt. Ltd.

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View Lastest Price from (S)-3-[(S)-2-((S)-1-ETHOXYCARBONYL-3-PHENYL-PROPYLAMINO)-PROPIONYL]-1-METHYL-2-OXO-IMIDAZOLIDINE-4-CARBOXYLIC ACID manufacturers

Hebei Mingeng Biotechnology Co., Ltd

Product: Imidapril hydrochloride 89396-94-1
Price: US $150.00/ASSAYS
Min. Order: 10g
Purity: >99%
Supply Ability: 500kg/month
Release date: 2021-10-09

Career Henan Chemical Co

Product: (S)-3-[(S)-2-((S)-1-ETHOXYCARBONYL-3-PHENYL-PROPYLAMINO)-PROPIONYL]-1-METHYL-2-OXO-IMIDAZOLIDINE-4-CARBOXYLIC ACID 89396-94-1
Price: US $33.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000kg
Release date: 2019-07-09

89396-94-1, (S)-3-[(S)-2-((S)-1-ETHOXYCARBONYL-3-PHENYL-PROPYLAMINO)-PROPIONYL]-1-METHYL-2-OXO-IMIDAZOLIDINE-4-CARBOXYLIC ACIDRelated Search:

Imidapril Cefaclor Tariquidar Valsartan Lopinavir MPI-0479605 Ramipril

(S)-3-[(S)-2-((S)-1-ETHOXYCARBONYL-3-PHENYL-PROPYLAMINO)-PROPIONYL]-1-METHYL-2-OXO-IMIDAZOLIDINE-4-CARBOXYLIC ACID

(S)-3-[(S)-2-((S)-1-ETHOXYCARBONYL-3-PHENYL-PROPYLAMINO)-PROPIONYL]-1-METHYL-2-OXO-IMIDAZOLIDINE-4-CARBOXYLIC ACID: HYDROCHLORIDE

ACE/TA-6366

Novarok

SH-6366

Imidaprilhydrochloride

4-Imidazolidinecarboxylic acid, 3-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1-methyl-2-oxo-, monohydrochloride, (4S)-

4-Imidazolidinecarboxylic acid, 3-[2-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1-methyl-2-oxo-, monohydrochloride, [4S-[3[R*(R*)],4R*]]-

Novaloc

TA 6366

Tanapril

(4S)-3-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-1-methyl-2-oxoimidazolidine-4-carboxylic acid,hydrochloride

(-)-(4S)-3-[2(S)-[N-[1(S)-(Ethoxycarbonyl)-3-phenylpropyl]amino]propionyl]-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride

Tanatril

Imidapril hydrochloride [jan]

Imidapril monohydrochloride

3-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1-methyl-2-oxo-4-imidazolidinecarboxylic acid hydrochloride

IMipadril HCl

IMidapril HCL & its interMediates

4-IMidazolidinecarboxylicacid,3-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]aMino]-1-oxopropyl]-1-Methyl-2-oxo-,hydrochloride (1:1), (4S)-

4-Imidazolidinecarboxylicacid,3-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1-methyl-2-oxo-,hydrochloride (1:1)

ImidaprilHydrochloride&gt

IMidapril Hydrochloride USP/EP/BP

(S)-3-[(S)-2-((S)-1-ETHOXYCARBONYL-3-PHENYL-PROPYLAMINO)-PROPIONYL]-1-METHYL-2-OXO-IMIDAZOLIDINE-4-CARBOXYLIC ACID USP/EP/BP

(S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride

Imidapril HCl (TA-6366)

Imidapril Hydrochloride (cGMP)

(-)-(4S)-3-[2(S)-[N-[1(S)-(Ethoxycarbonyl)-3-phenylpropyl]am...

Imidapril Hydrochloride (secondary standard)

89396-94-1

C20H27N3O6HCl

C20H28ClN3O6

C20H27N3O6ClH

Inhibitors