N-BOC-3-MESYLOXYPIPERIDINE

Product Name: N-BOC-3-MESYLOXYPIPERIDINE
CAS No.: 129888-60-4
Chemical Name: N-BOC-3-MESYLOXYPIPERIDINE
Synonyms: tert-Butyl 3-((methylsulfonyl);1-Boc-3-methanesulfonyloxy-piper;N-BOC-3-(Methylsulfonyloxy)piperidine;1-Boc-3-methanesulphonyloxypiperidine;3-((methylsulfonyl)oxy)piperidine-1-carboxylate;tert-Butyl 3-Methylsulfonyloxypiperidin-1-carboxylate;tert-Butyl 3-Methylsulfonyloxypiperidine-1-carboxylate;1-(tert-Butoxycarbonyl)-3-(methanesulfonyloxy)piperidine;tert-Butyl 3-(methanesulfonyloxy)piperidine-1-carboxylate;tert-Butyl 3-[(methylsulfonyloxy)]-1-piperidinecarboxylate
CBNumber: CB81011470
Molecular Formula: C11H21NO5S
Formula Weight: 279.35
MOL File: 129888-60-4.mol

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N-BOC-3-MESYLOXYPIPERIDINE Property

Melting point:: 67-70°
Boiling point:: 407.2±34.0 °C(Predicted)
Density: 1.22±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: -3.34±0.40(Predicted)
Appearance: White to yellow Solid
InChI: InChI=1S/C11H21NO5S/c1-11(2,3)16-10(13)12-7-5-6-9(8-12)17-18(4,14)15/h9H,5-8H2,1-4H3
InChIKey: WLAZHMYDLUILKR-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCCC(OS(C)(=O)=O)C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B663285
Product name: 1-Boc-3-Methanesulfonyloxy-piperidine
Packaging: 25mg
Price: $45
Updated: 2021/12/16

Oakwood

Product number: 047924
Product name: 1-Boc-3-methanesulfonyloxypiperidine
Packaging: 250mg
Price: $22
Updated: 2021/12/16

SynQuest Laboratories

Product number: 8H64-1-05
Product name: tert-Butyl 3-(methanesulfonyloxy)piperidine-1-carboxylate
Purity: 98.0%
Packaging: 1g
Price: $79
Updated: 2021/12/16

Matrix Scientific

Product number: 068941
Product name: tert-Butyl 3-methylsulfonyloxypiperidine-1-carboxylate
Purity: >95%
Packaging: 1g
Price: $189
Updated: 2021/12/16

SynQuest Laboratories

Product number: 8H64-1-05
Product name: tert-Butyl 3-(methanesulfonyloxy)piperidine-1-carboxylate
Purity: 98.0%
Packaging: 5G
Price: $189
Updated: 2021/12/16

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N-BOC-3-MESYLOXYPIPERIDINE Chemical Properties,Usage,Production

Synthesis

85275-45-2

124-63-0

129888-60-4

Step 1. To a stirred solution of tert-butyl 3-hydroxypiperidine-1-carboxylate (5 g, 24.84 mmol) and triethylamine (5.027 g, 6.924 mL, 49.68 mmol) in dichloromethane (50 mL) was slowly added methanesulfonyl chloride (3.130 g, 2.115 mL, 27.32 mmol) under the conditions of an ice bath at 0°C. The reaction mixture was gradually warmed to room temperature over 3 hours. Upon completion of the reaction, the reaction mixture was washed with water and 1 M hydrochloric acid, followed by drying with magnesium sulfate, filtration and concentration in vacuum to afford tert-butyl 3-((methanesulfonyl)oxy)piperidine-1-carboxylate as a yellow oil (7.9 g, quantitative yield, with a small amount of residual solvent).1H NMR (400.0 MHz, CDCl3) δ 1.49 (s, 9H), 1.60- 1.57 (m, 1H), 2.04-1.79 (m, 3H), 3.08 (s, 3H), 3.38-3.32 (m, 1H), 3.50-3.43 (m, 1H), 3.70-3.60 (m, 2H) and 4.74 (br s, 1H) ppm.

References

[1] Patent: US2013/115310, 2013, A1. Location in patent: Paragraph 0248; 0249
[2] Patent: US2016/168156, 2016, A1. Location in patent: Paragraph 0485; 0486
[3] Carbohydrate Research, 1990, vol. 204, # 1, p. 11 - 25
[4] Journal of Medicinal Chemistry, 1992, vol. 35, # 23, p. 4334 - 4343
[5] Patent: US2017/305920, 2017, A1. Location in patent: Paragraph 0151; 0152

N-BOC-3-MESYLOXYPIPERIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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N-BOC-3-MESYLOXYPIPERIDINE Suppliers

China 63 Germany 1 India 1 Switzerland 1 United States 10 Global 76

Jiangsu Yaoheng Pharmaceutical Technology Co., Ltd.

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129888-60-4, N-BOC-3-MESYLOXYPIPERIDINERelated Search:

1-BOC-3-BROMOMETHYLPIPERIDINE TERT-BUTYL 3-(2-BROMOETHYL)PIPERIDINE-1-CARBOXYLATE N-(TERT-BUTOXYCARBONYL)-L-SERINE BETA-LACTONE N-Boc-2-amino-5-bromo[1,3,4]thiadiazole 1-BOC-3-(TOLUENE-4-SULFONYLOXY)-PIPERIDINE (R)-1-(TERT-BUTOXYCARBONYL)PIPERIDIN-3-YL METHANESULFONATE (S)-1-(TERT-BUTOXYCARBONYL)PIPERIDIN-3-YL METHANESULFONATE 4,6-O-BENZYLIDENE-N-(TERT-BUTOXYCARBONYL)-2-O-(4-TOLUENESULFONYL)-1,5-IMINO-D-GLUCITOL N-BOC-3-MESYLOXYPIPERIDINE

tert-Butyl 3-Methylsulfonyloxypiperidin-1-carboxylate

tert-Butyl 3-Methylsulfonyloxypiperidine-1-carboxylate

3-(Methylsulfonyloxy)piperidine-1-carboxylic acid tert-butyl ester

1-Piperidinecarboxylic acid, 3-[(Methylsulfonyl)oxy]-, 1,1-diMethylethyl ester

tert-Butyl 3-((methylsulfonyl)

1-Boc-3-methanesulphonyloxypiperidine

N-BOC-3-(Methylsulfonyloxy)piperidine

3-methylsulfonyloxy-1-piperidinecarboxylic acid tert-butyl ester

tert-Butyl 3-(methanesulfonyloxy)piperidine-1-carboxylate

1-(tert-Butoxycarbonyl)-3-(methanesulfonyloxy)piperidine

1-Boc-3-methanesulfonyloxy-piper

1,1-Dimethylethyl 3-[(methylsulfonyl)oxy]-1-piperidinecarboxylate

3-((methylsulfonyl)oxy)piperidine-1-carboxylate

tert-Butyl 3-[(methylsulfonyloxy)]-1-piperidinecarboxylate

129888-60-4