(S)-1-(TERT-BUTOXYCARBONYL)PIPERIDIN-3-YL METHANESULFONATE
- Product Name
- (S)-1-(TERT-BUTOXYCARBONYL)PIPERIDIN-3-YL METHANESULFONATE
- CAS No.
- 940890-90-4
- Chemical Name
- (S)-1-(TERT-BUTOXYCARBONYL)PIPERIDIN-3-YL METHANESULFONATE
- Synonyms
- (methylsulfonyloxy)(S)-1-Boc-3-mesyloxyl-piperidine;(S)-1-BOC-3-(Methylsulfonyloxy)piperidine;(S)-1-(TERT-BUTOXYCARBONYL)PIPERIDIN-3-YL METHANESULFONATE;Tert-butyl (3S)-3-methylsulfonyloxypiperidine-1-carboxylate;1Piperidinecarboxylic acid, 3[(methylsulfonyl)oxy], 1,1dimeth;tert-butyl (S)-3-((methylsulfonyl)oxy)piperidine-1-carboxylate;1-Piperidinecarboxylic acid, 3-[(Methylsulfonyl)oxy]-, 1,1-diMethylethyl ester, (3S)-;2-Methyl-2-propanyl (3S)-3-[(methylsulfonyl)oxy]-1-piperidinecarboxylate (S)tertButyl 3(methylsulfonyloxy)piperidine1carboxylate
- CBNumber
- CB52453133
- Molecular Formula
- C11H21NO5S
- Formula Weight
- 279.35
- MOL File
- 940890-90-4.mol
(S)-1-(TERT-BUTOXYCARBONYL)PIPERIDIN-3-YL METHANESULFONATE Property
- storage temp.
- 2-8°C
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T135890
- Product name
- tert-Butyl(3S)-3-[(Methylsulfonyl)oxy]piperidine-1-carboxylate
- Packaging
- 250mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- T135890
- Product name
- tert-Butyl(3S)-3-[(Methylsulfonyl)oxy]piperidine-1-carboxylate
- Packaging
- 500mg
- Price
- $265
- Updated
- 2021/12/16
- Product number
- CCH0031851
- Product name
- (S)-TERT-BUTYL-3-(METHYLSULFONYLOXY)PIPERIDINE-1-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 0.25G
- Price
- $231
- Updated
- 2021/12/16
- Product number
- Y4777
- Product name
- (S)-tert-Butyl3-(methylsulfonyloxy)piperidine-1-carboxylate
- Packaging
- 1g
- Price
- $359
- Updated
- 2021/12/16
- Product number
- A878895
- Product name
- (S)-tert-Butyl3-((methylsulfonyl)oxy)piperidine-1-carboxylate
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $68
- Updated
- 2021/12/16
(S)-1-(TERT-BUTOXYCARBONYL)PIPERIDIN-3-YL METHANESULFONATE Chemical Properties,Usage,Production
Uses
tert-Butyl (3S)-3-[(Methylsulfonyl)oxy]piperidine-1-carboxylate is used as a reactant in the synthesis of non-nucleoside MtbTMPK inhibitors.
Synthesis
124-63-0
143900-44-1
940890-90-4
Under nitrogen protection, (S)-1-Boc-3-hydroxypiperidine (10.0 g, 49.7 mmol) and triethylamine (7.82 mL, 54.7 mmol) were dissolved in dichloromethane (60 mL) and cooled to 0 °C. Subsequently, methanesulfonyl chloride (4.23 mL, 54.7 mmol) was slowly added dropwise and the reaction mixture was stirred at this temperature for 1 hour. Upon completion of the reaction, the reaction solution was diluted with deionized water (60 mL) and filtered through a hydrophobic glass stock. The organic layer was concentrated under reduced pressure to afford tert-butyl (3S)-3-(methylsulfonyloxy)piperidine-1-carboxylate (13.9 g, 49.7 mmol, 100% yield) as a colorless solid. The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ (ppm) 4.76-4.71 (m, 1H, CH), 3.69-3.66 (m, 1H), 3.65-3.60 (m, 1H), 3.49-3.43 (m, 1H), 3.37-3.31 (m, 1H), 3.07 (s, 3H, CH3) , 2.02-1.96 (m, 1H), 1.94-1.91 (m, 1H), 1.87-1.80 (m, 1H), 1.59-1.53 (m, 1H), 1.48-1.45 (m, 9H).
References
[1] Patent: WO2014/188173, 2014, A1. Location in patent: Paragraph 00224
[2] Patent: CN105399756, 2016, A. Location in patent: Paragraph 0152; 0167-0168
[3] MedChemComm, 2014, vol. 5, # 12, p. 1879 - 1886
[4] Patent: WO2017/134684, 2017, A2. Location in patent: Page/Page column 12
[5] Patent: CN103864673, 2016, B. Location in patent: Paragraph 0084; 0085
(S)-1-(TERT-BUTOXYCARBONYL)PIPERIDIN-3-YL METHANESULFONATE Preparation Products And Raw materials
Raw materials
Preparation Products
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