2-AMINO-5-BROMO-BENZOIC ACID ETHYL ESTER
- Product Name
- 2-AMINO-5-BROMO-BENZOIC ACID ETHYL ESTER
- CAS No.
- 63243-76-5
- Chemical Name
- 2-AMINO-5-BROMO-BENZOIC ACID ETHYL ESTER
- Synonyms
- ETHYL 2-AMINO-5-BROMOBENZOATE;2-AMINO-5-BROMO-BENZOIC ACID ETHYL ESTER;Benzoic acid, 2-aMino-5-broMo-, ethyl ester
- CBNumber
- CB8103329
- Molecular Formula
- C9H10BrNO2
- Formula Weight
- 244.09
- MOL File
- 63243-76-5.mol
2-AMINO-5-BROMO-BENZOIC ACID ETHYL ESTER Property
- Melting point:
- 187 °C(Solv: ethanol (64-17-5))
- Boiling point:
- 301.2±22.0 °C(Predicted)
- Density
- 1.503±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 1.77±0.10(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- E899850
- Product name
- Ethyl2-Amino-5-bromobenzoate
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 038708
- Product name
- Ethyl 2-Amino-5-bromobenzoate
- Packaging
- 1g
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 3339AL
- Product name
- Ethyl2-amino-5-bromobenzoate
- Packaging
- 5g
- Price
- $151
- Updated
- 2021/12/16
- Product number
- 038708
- Product name
- Ethyl 2-Amino-5-bromobenzoate
- Packaging
- 5g
- Price
- $200
- Updated
- 2021/12/16
- Product number
- HCH0011065
- Product name
- 2-AMINO-5-BROMO-BENZOIC ACID ETHYL ESTER
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $692.46
- Updated
- 2021/12/16
2-AMINO-5-BROMO-BENZOIC ACID ETHYL ESTER Chemical Properties,Usage,Production
Synthesis
64-17-5
5794-88-7
63243-76-5
To a 100 mL three-necked round-bottomed flask was added 2-amino-5-bromobenzoic acid (5 g, 23.14 mmol, 1.00 equiv) and anhydrous ethanol (100 mL). Dry hydrogen chloride gas was passed to saturation and the reaction mixture was subsequently heated to reflux for 12 hours. Upon completion of the reaction, saturated sodium bicarbonate solution was slowly added to neutralize the reaction system. The solvent was removed by distillation under reduced pressure to give the crude product. The crude product was purified by fast column chromatography (silica gel, eluent ratio was adjusted according to the TLC results) to give ethyl 2-amino-5-bromobenzoate (2.5 g, 44% yield) as a yellow solid.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 19, p. 5746 - 5752
[2] Patent: WO2014/182951, 2014, A1. Location in patent: Paragraph 00281
[3] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 23, p. 6481 - 6488
[4] Patent: EP1180514, 2002, A1. Location in patent: Example 75
[5] Journal of Organic Chemistry, 2018, vol. 83, # 3, p. 1154 - 1159
2-AMINO-5-BROMO-BENZOIC ACID ETHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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