CH 55
- Product Name
- CH 55
- CAS No.
- 110368-33-7
- Chemical Name
- CH 55
- Synonyms
- CH 55;4-[(E)-3-(3,5-Di-tert-butylphenyl)-3-oxo-1-propenyl]benzoic acid;4-[(E)-3-[3,5-Bis(tert-butyl)phenyl]-3-oxo-1-propenyl]benzoic acid;(E)-4-(3-(3,5-Di-tert-butylphenyl)-3-oxoprop-1-en-1-yl)benzoic acid;(E)-4-(3-(3,5-Bis(1,1-dimethylethyl)phenyl)-3-oxo-1-propenyl)benzoic acid;4-[(E)-3-[3,5-Bis(1,1-dimethylethyl)phenyl]-3-oxo-1-propenyl]benzoic acid;4-[(1E)-3-[3,5-BIS(1,1-DIMETHYLETHYL)PHENYL]-3-OXO-1-PROPENYL]BENZOIC ACID;Benzoic acid, 4-(3-(3,5-bis(1,1-dimethylethyl)phenyl)-3-oxo-1-propenyl)-, (E)-;Benzoic acid, 4-[(1E)-3-[3,5-bis(1,1-dimethylethyl)phenyl]-3-oxo-1-propen-1-yl]-
- CBNumber
- CB8103738
- Molecular Formula
- C24H28O3
- Formula Weight
- 364.48
- MOL File
- 110368-33-7.mol
CH 55 Property
- Melting point:
- 202-203.5 °C
- Boiling point:
- 509.5±50.0 °C(Predicted)
- Density
- 1.085±0.06 g/cm3(Predicted)
- storage temp.
- Store at RT
- solubility
- DMF: 25 mg/ml; DMSO: 25 mg/ml; DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml; Ethanol: 5 mg/ml
- form
- A crystalline solid
- pka
- 4.09±0.10(Predicted)
- Stability:
- Light Sensitive
N-Bromosuccinimide Price
- Product number
- 18658
- Product name
- Ch 55
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 18658
- Product name
- Ch 55
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $98
- Updated
- 2024/03/01
- Product number
- 18658
- Product name
- Ch 55
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $161
- Updated
- 2024/03/01
- Product number
- 18658
- Product name
- Ch 55
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $353
- Updated
- 2024/03/01
- Product number
- 2020
- Product name
- Ch55
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $171
- Updated
- 2021/12/16
CH 55 Chemical Properties,Usage,Production
Uses
CH 55 is a synthetic analog of retinoic acid which is an effective inhibitor of angiogenesis. Retinoids and their analogs are also promising agents for cancer chemoprevention and therapy.
Definition
ChEBI: 4-[3-(3,5-ditert-butylphenyl)-3-oxoprop-1-enyl]benzoic acid is a member of chalcones.
Biological Activity
Highly potent synthetic retinoid that has high affinity for RAR- α and RAR- β receptors and low affinity for cellular retinoic acid binding protein (CRABP). Inhibits rabbit tracheal epithelial cell differentiation by inhibiting transglutaminase and increasing cholesterol sulfate (EC 50 values are 0.02 and 0.03 nM respectively). Induces differentiation of embryonic carcinoma F9 and melanoma S91 cells (EC 50 values are 0.26 and 0.5 nM respectively) and inhibits the induction of ornithine decarboxylase activity in 3T6 fibroblasts (EC 50 = 1 nM).
storage
Store at RT