ChemicalBook > CAS DataBase List > D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-, 6-(2-methylpropanoate)

D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-, 6-(2-methylpropanoate)

Product Name
D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-, 6-(2-methylpropanoate)
CAS No.
2647441-36-7
Chemical Name
D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-, 6-(2-methylpropanoate)
Synonyms
Obeldesivir;SHEN26;SHEN26, 10 mM in DMSO;D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-, 6-(2-methylpropanoate);5-ethenyl-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione;((2R,3S,4R,5R)-5-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methyl isobutyrate;RNA,SHEN26,viral load,ATV 006,ATV006,antiviral,SARS coronavirus,Vero E6 cells,podrugs,Inhibitor,ATV-006,SARS-CoV,inhibit
CBNumber
CB810690992
Molecular Formula
C16H19N5O5
Formula Weight
361.36
MOL File
2647441-36-7.mol
More
Less

D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-, 6-(2-methylpropanoate) Property

Density 
1.59±0.1 g/cm3(Predicted)
storage temp. 
4°C, protect from light
solubility 
DMSO : 250 mg/mL (691.85 mM; Need ultrasonic)
form 
Solid
pka
12.00±0.70(Predicted)
color 
White to off-white
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
40404
Product name
Obeldesivir
Purity
≥98%
Packaging
1mg
Price
$72
Updated
2026/04/30
Cayman Chemical
Product number
40404
Product name
Obeldesivir
Purity
≥98%
Packaging
5mg
Price
$323
Updated
2026/04/30
Cayman Chemical
Product number
40404
Product name
Obeldesivir
Purity
≥98%
Packaging
10mg
Price
$501
Updated
2026/04/30
Cayman Chemical
Product number
40404
Product name
Obeldesivir
Purity
≥98%
Packaging
25mg
Price
$895
Updated
2026/04/30
Matrix Scientific
Product number
302161
Product name
((2R,3S,4R,5R)-5-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methyl isobutyrate
Packaging
50.00mg
Price
$76
Updated
2026/05/19
More
Less

D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-, 6-(2-methylpropanoate) Chemical Properties,Usage,Production

Uses

Obeldesivir (ATV006) is a potent, orally active antiviral agent and ester proagents of GS-441524. Obeldesivir inhibits the replication of SARS-CoV-2 and its variants. Obeldesivir can be used for SARS-CoV-2 research[1].

in vivo

Obeldesivir (5-25 mg/kg; p.o. and i.v.; Sprague Dawley rats) has favorable pharmacokinetic profiles in rats with high oral bioavailability (F %) of 81.5% and maximum blood concentration (Cmax) of 8.2 μM[1].
Obeldesivir (250-500 mg/kg; p.o.; daily, for 4 days; hACE2 knock-in and Ad5-hACE2 mice) has antiviral activity and inhibits SARS-CoV-2 replication in mouse models[1].
Obeldesivir (100-250 mg/kg; p.o.; daily, for 10 days) reduces lung damage and protects K18-hACE2 mice[1].
Obeldesivir (10-150 mg/kg; p.o.; daily, for 3 days) reduces virus titers and lung damage caused by Delta variant infection in K18-hACE2 mice[1].

Animal Model:Sprague Dawley rats[1]
Dosage:5 and 25 mg/kg
Administration:Oral administration (25 mg/kg) and intravenous injection (5 mg/kg)
Result:1.19
parametersi.v. (5 mg/kg)p.o. (25 mg/kg)
AUClast (μM·h)5.622.8
T1/2 (h)1.51.2
Tmax (h)0.5
Cmax (μM)8.78.2
F %81.5
Animal Model:hACE2 knock-in and Ad5-hACE2 mice[1]
Dosage:250 and 500 mg/kg
Administration:Oral administration; daily, for 4 days
Result:Inhibited gRNA and sgRNA, which is Biomarkers of coronavirus replication. Reduced the viral load and pathological damage of the lung.
Animal Model:K18-hACE2 mice[1]
Dosage:100 and 250 mg/kg
Administration:Oral administration; daily, for 10 days
Result:Reduced viral RNA and increased the survival rate of mice. Reduced evidence of lung pathology and the production of inflammatory cytokines and chemokines in the lung tissues.
Animal Model:K18-hACE2 mice[1]
Dosage:10, 30, 80 and 150 mg/kg
Administration:Oral administration; daily, for 3 days
Result:Reduced viral load in a dose-dependent manner and alleviated the symptoms in the lung.

References

[1] Cao L, et, al. The adenosine analog prodrug ATV006 is orally bioavailable and has preclinical efficacy against parental SARS-CoV-2 and variants. Sci Transl Med. 2022 May 17:eabm7621. DOI:10.1126/scitranslmed.abm7621

D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-, 6-(2-methylpropanoate) Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-, 6-(2-methylpropanoate) Suppliers

China 28 United States 2 Global 30
Shanghai Synmedia Chemical Co., Ltd.
Tel
021-38681880 13817889927
Fax
0213390-8196
Email
sales@synmedia-chem.com
Country
China
ProdList
249
Advantage
58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4845
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai Rechem science Co., Ltd.
Tel
021-31433387 15618786686
Fax
QQ:1369748377
Email
sales@rechemscience.com
Country
China
ProdList
2970
Advantage
58
Suzhou Rovathin Foreign Trade Co.,Ltd
Tel
0512-65816829 18662214788
Fax
0512-65816829
Email
info@rovathin.com.cn
Country
China
ProdList
9978
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32466
Advantage
58
Wuxi Donghe Pharmaceutical Technology Co., Ltd.
Tel
63313187 15358055255
Fax
QQ：63313187
Email
63313187@qq.com
Country
China
ProdList
1983
Advantage
58
Nantong Hi-Future Biotechnology Co., Ltd
Tel
18051384581
Email
sales@chemhifuture.com
Country
China
ProdList
2987
Advantage
58
Bide Pharmatech Ltd.
Tel
400-1647117 13681763483
Email
product02@bidepharm.com
Country
China
ProdList
59936
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310 15002144251
Email
marketing@tsbiochem.com
Country
China
ProdList
24955
Advantage
58

2647441-36-7, D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-, 6-(2-methylpropanoate)Related Search:

PH-797804 RGB-286638 (free base) GSK2141795 SR9009 Fexaramine TD52 BAM15 (3aR,6aR)-N-(4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)-1-methylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxamide TG4-155 NVP-TAE684

  • D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-, 6-(2-methylpropanoate)
  • RNA,SHEN26,viral load,ATV 006,ATV006,antiviral,SARS coronavirus,Vero E6 cells,podrugs,Inhibitor,ATV-006,SARS-CoV,inhibit
  • ((2R,3S,4R,5R)-5-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methyl isobutyrate
  • SHEN26, 10 mM in DMSO
  • 5-ethenyl-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione
  • Obeldesivir
  • SHEN26
  • 2647441-36-7