ChemicalBook > CAS DataBase List > Compstatin

Compstatin

Product Name
Compstatin
CAS No.
206645-99-0
Chemical Name
Compstatin
Synonyms
Compstatin;Compstatin，ICVVQDWGHHRCT;Compstatin,ICVVQDWGHHRCT, >98%;Complement System,Inhibitor,Compstatin,inhibit;H-Ile-Cys-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-Cys-Thr-NH2;H-Ile-Cys-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-Cys-Thr-NH2, (Disulfide bond);Compstatin trifluoroacetate salt H-Ile-Cys-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-Cys-Thr-NH2 trifluoroacetate salt (Disulfide bond);L-Threoninamide, L-isoleucyl-L-cysteinyl-L-valyl-L-valyl-L-glutaminyl-L-α-aspartyl-L-tryptophylglycyl-L-histidyl-L-histidyl-L-arginyl-L-cysteinyl-, cyclic (2→12)-disulfide;2-((4R,7S,10S,13S,19S,22S,25S,28S,31S,34R)-10,13-Bis((1H-imidazol-4-yl)methyl)-19-((1H-indol-3-yl)methyl)-4-(((2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl)carbamoyl)-34-((2S,3S)-2-amino-3-methylpentanamido)-25-(3-amino-3-oxopropyl)-7-(3-guanidinopropyl)-28,31-diisopropyl-6,9,12,15,18,21,24,27,30,33-decaoxo-1,2-dithia-5,8,11,14,17,20,23,26,29,32-decaazacyclopentatriacontan-22-yl)acetic acid
CBNumber
CB81073593
Molecular Formula
C66H99N23O17S2
Formula Weight
1550.77
MOL File
206645-99-0.mol
More
Less

Compstatin Property

Density 
1.56±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
pka
4.00±0.10(Predicted)
form 
Solid
color 
White to off-white
Water Solubility 
Soluble to 2 mg/ml in sterile water
Sequence
H-Ile-Cys-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-Cys-Thr-NH2(Disulfide bridge: Cys2-Cys11)
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Tocris
Product number
2585
Product name
Compstatin
Packaging
1
Price
$235
Updated
2021/12/16
Usbiological
Product number
255025
Product name
Compstatin
Packaging
1mg
Price
$538
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC109863
Product name
Compstatin trifluoroacetate salt H-Ile-Cys-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-Cys-Thr-NH2 trifluoroacetate salt (Disulfide bond)
Packaging
1mg
Price
$410
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0007963
Product name
COMPSTATIN
Purity
95.00%
Packaging
5MG
Price
$499.65
Updated
2021/12/16
ChemScene
Product number
CS-7604
Product name
Compstatin
Packaging
5mg
Price
$270
Updated
2021/12/16
More
Less

Compstatin Chemical Properties,Usage,Production

Uses

Compstatin, a 13-residue cyclic peptide, is a potent inhibitor of the complement system C3 with species specificity. Compstatin binds to baboon C3 and is resistant to proteolytic cleavage in baboon blood (similar to humans). Compstatin inhibits only the activation of primates’ complement system. Compstatin exhibits IC50 values of 63 μM and 12 μM for classical and alterative complement pathway, respectively[1][2][3][4].

in vivo

Compstatin (21 mg/kg) produces complete inhibition when given as a combination of bolus injection and infusion. Compstatin completely inhibits in vivo heparin/protamine-induced complement activation without adverse effects on heart rate or systemic arterial, central venous, and pulmonary arterial pressures[1].
Compstatin is stable in baboon plasma for more than 24 h[1].
Pig xenografts survival is significantly longer in the Compstatin perfused group than in the control group[2].

Animal Model:Juvenile baboons (P. Anubis) weighing 10.5-28.8 kg[1].
Dosage:50, 25 mg/kg 60 min after heparin and 2 min before protamine.
Administration:A bolus injection.
Result:Completely inhibited complement activation induced by heparin–protamine complexes.

storage

Store at -20°C

References

[1] Soulika AM, et al. Inhibition of heparin/protamine complex-induced complement activation by Compstatin in baboons. Clin Immunol. 2000 Sep;96(3):212-21. DOI:10.1006/clim.2000.4903
[2] Fiane AE, et al. Compstatin, a peptide inhibitor of C3, prolongs survival of ex vivo perfused pig xenografts. Xenotransplantation. 1999 Feb;6(1):52-65. DOI:10.1034/j.1399-3089.1999.00007.x
[3] Bert J C Janssen, et al. Structure of compstatin in complex with complement component C3c reveals a new mechanism of complement inhibition. J Biol Chem. 2007 Oct 5;282(40):29241-7. DOI:10.1074/jbc.M704587200
[4] A Sahu, et al. Inhibition of human complement by a C3-binding peptide isolated from a phage-displayed random peptide library. J Immunol. 1996 Jul 15;157(2):884-91. PMID:8752942

Compstatin Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Compstatin Suppliers

China 84 Germany 1 India 1 United Kingdom 2 United States 7 Global 95
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
Creative Peptides
Tel
Email
info@creative-peptides.com
Country
United States
ProdList
6083
Advantage
56
Alfa Chemistry
Tel
+1-5166625404;
Fax
1-516-927-0118
Email
Info@alfa-chemistry.com
Country
United States
ProdList
20405
Advantage
58
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19552
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
52923
Advantage
58
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
More
Less

View Lastest Price from Compstatin manufacturers

Career Henan Chemical Co
Product
Compstatin 206645-99-0
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-02-13

206645-99-0, CompstatinRelated Search:

Compstatin

  • H-Ile-Cys-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-Cys-Thr-NH2
  • Compstatin
  • H-Ile-Cys-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-Cys-Thr-NH2, (Disulfide bond)
  • Compstatin trifluoroacetate salt H-Ile-Cys-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-Cys-Thr-NH2 trifluoroacetate salt (Disulfide bond)
  • Compstatin,ICVVQDWGHHRCT, >98%
  • L-Threoninamide, L-isoleucyl-L-cysteinyl-L-valyl-L-valyl-L-glutaminyl-L-α-aspartyl-L-tryptophylglycyl-L-histidyl-L-histidyl-L-arginyl-L-cysteinyl-, cyclic (2→12)-disulfide
  • Compstatin，ICVVQDWGHHRCT
  • Complement System,Inhibitor,Compstatin,inhibit
  • 2-((4R,7S,10S,13S,19S,22S,25S,28S,31S,34R)-10,13-Bis((1H-imidazol-4-yl)methyl)-19-((1H-indol-3-yl)methyl)-4-(((2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl)carbamoyl)-34-((2S,3S)-2-amino-3-methylpentanamido)-25-(3-amino-3-oxopropyl)-7-(3-guanidinopropyl)-28,31-diisopropyl-6,9,12,15,18,21,24,27,30,33-decaoxo-1,2-dithia-5,8,11,14,17,20,23,26,29,32-decaazacyclopentatriacontan-22-yl)acetic acid
  • 206645-99-0
  • C66H99N23O17S2