ChemicalBook > CAS DataBase List > 1,3-Dioxo-2-isoindolineaceticacid

1,3-Dioxo-2-isoindolineaceticacid

Product Name
1,3-Dioxo-2-isoindolineaceticacid
CAS No.
6296-53-3
Chemical Name
1,3-Dioxo-2-isoindolineaceticacid
Synonyms
3-AcetaMidophthalic anhydride;N-(1,3-dioxo-1,3-dihydroisobenzofuran-4-yl)acetaMide;3-AcetylaMinophthalic Anhydride;NSC 17048;NSC 16261;1,3-Dioxo-2;Apremilast inter1;Apremilast Impurity 43;Apremilast Intermediates1;Apremilast Intermediate III
CBNumber
CB81073957
Molecular Formula
C10H7NO4
Formula Weight
205.17
MOL File
6296-53-3.mol
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1,3-Dioxo-2-isoindolineaceticacid Property

Melting point:
185-186℃
Boiling point:
489.1±28.0 °C(Predicted)
Density 
1.512±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Chloroform (Slightly, Sonicated), Ethyl Acetate (Slightly, Sonicated), Methanol
form 
Solid
pka
13.81±0.20(Predicted)
color 
Off-White to Pale Yellow
Stability:
Moisture Sensitive
InChI
InChI=1S/C10H7NO4/c1-5(12)11-7-4-2-3-6-8(7)10(14)15-9(6)13/h2-4H,1H3,(H,11,12)
InChIKey
PAUAJOABXCGLCN-UHFFFAOYSA-N
SMILES
C(NC1=CC=CC2C(=O)OC(=O)C1=2)(=O)C
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Safety

HS Code 
2924.29.7790
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TCI Chemical
Product number
A2804
Product name
3-Acetamidophthalic Anhydride
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$37
Updated
2025/07/31
TCI Chemical
Product number
A2804
Product name
3-Acetamidophthalic Anhydride
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$47
Updated
2025/07/31
TRC
Product number
A170980
Product name
3-AcetylaminophthalicAnhydride
Packaging
10g
Price
$1190
Updated
2021/12/16
AK Scientific
Product number
3875AH
Product name
3-Acetamidophthalic Anhydride
Packaging
1g
Price
$19
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA63286
Product name
3-Acetamidophthalic anhydride
Packaging
1g
Price
$60
Updated
2021/12/16
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1,3-Dioxo-2-isoindolineaceticacid Chemical Properties,Usage,Production

Uses

3-Acetylaminophthalic Anhydride is used in the synthesis of Apremilast, a potent phosphodiesterase 4 and tumor necrosis Factor-α inhibitor used in the treatment of psoriatic arthritis. Also a reagent in the preparation of Tillivalline. Apremilast Impurity 2

Synthesis

603-11-2

108-24-7

6296-53-3

General procedure for the synthesis of N-(1,3-dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide from 3-nitrophthalic acid and acetic anhydride: 3-nitrophthalic acid (100.0 g) and acetic anhydride (1 L) were added to a hydrogenation kettle and heated to 80 °C until the raw materials were completely dissolved. Subsequently, the reaction mixture was cooled to room temperature and 10% Pd/C catalyst (3 g) was added. The atmosphere in the reaction kettle was replaced twice with nitrogen, then hydrogen was introduced to a pressure of 1 MPa, and the reaction was kept at room temperature until hydrogen absorption stopped. Upon completion of the reaction, the hydrogen was vented and the reactor was purged with nitrogen. Next, the reaction mixture was heated to 110-115 °C until the feedstock or intermediate completely disappeared. Thermal filtration was carried out and the filtrate was cooled to 0-5 °C, the product was collected by filtration and washed with glacial acetic acid. A final light yellow crystalline product of 80.6 g was obtained with 83% yield and 99.0% HPLC purity.

References

[1] Patent: CN105294534, 2016, A. Location in patent: Paragraph 0036; 0037

1,3-Dioxo-2-isoindolineaceticacid Preparation Products And Raw materials

Raw materials

Preparation Products

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1,3-Dioxo-2-isoindolineaceticacid Suppliers

Americas 1 China 239 Europe 1 Germany 2 India 50 Japan 1 Switzerland 1 United Kingdom 2 United States 13 Global 310
TCI Europe
Tel
320-37350700
Fax
+32 (0)37350701
Email
sales@tcieurope.eu
Country
Europe
ProdList
23671
Advantage
75
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View Lastest Price from 1,3-Dioxo-2-isoindolineaceticacid manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd
Product
1,3-Dioxo-2-isoindolineaceticacid 6296-53-3
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
Customise
Release date
2025-11-27
Shaanxi Dideu Medichem Co. Ltd
Product
1,3-Dioxo-2-isoindolineaceticacid 6296-53-3
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
2000tons
Release date
2025-08-22
WUHAN FORTUNA CHEMICAL CO., LTD
Product
1,3-Dioxo-2-isoindolineaceticacid 6296-53-3
Price
US $0.00/g
Min. Order
1g
Purity
98.0%
Supply Ability
10kg/month
Release date
2021-12-17

6296-53-3, 1,3-Dioxo-2-isoindolineaceticacidRelated Search:

Cyclohexanone Hydantoin (S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethanaMine Apremilast Impurity E Apremilast Impurity 1 (S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt Apremilast Impurity 1/2 Apremilast Impurity 8 Apremilast Impurity 13 Apremilast Impurity 28 Apremilast Impurity 25 Apremilast-d8 (S)-N-(2-(1-(3-ethoxy-4-hydroxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide APST-ZA Apremilast Impurity 2 Apremilast Impurity 9 Apremilast impurity 18 Apremilast Impurity 15

  • N-(1,3-Dihydro-1,3-dioxoisobenzofuran-4-yl)acetamide
  • AcetaMide, N-(1,3-dihydro-1,3-dioxo-4-isobenzofuranyl)-
  • 3-AcetylaMino-phthalsaeure-anhydrid
  • 3-AcetaMidophthalic anhydride
  • 1,3-Dioxo-2-isoindolineaceticacid CAS:6296-53-3
  • 3-AcetylaMinophthalic Anhydride
  • N-(1,3-Dioxo-1,3-dihydro-2-benzofuran-4-yl)acetaMide
  • NSC 16261
  • NSC 17048
  • N-(1,3-dioxo-1,3-dihydroisobenzofuran-4-yl)acetaMide
  • N-(1,3-Dioxo-4-isobenzofuranyl)acetaMide
  • Apremilast Intermediate III
  • 3-Acetamidophthalic anhydride NSC 16261
  • N-(1,3-dioxo-2-benzofuran-4-yl)acetamide
  • N-(1,3-Dihydro-1,3-dioxo-4-isobenzofuranyl)acetamide
  • 1,3-Dioxo-2
  • RE-EXPORT OF REJECTED IMPORT MATERIAL: N -(1,3-DIHYDROIS OBENZOFURAN-4-YL) ACETAM IDE SYNONYM: 3-ACETAMIDOPHTHALIC ANHYDRI
  • Apremilast inter1
  • Apremilast Intermediates1
  • N-(1,3-Dioxo-1,3-dihydro-2- benzofuran-4-yl)acetamide Apremilast
  • N-(1,3-dioxo-1,3-dihydroisobenzofuran-4-yl)
  • Apremilast Impurity 43
  • 3-Aceta amido pthalic anhydride
  • 3-Acetamidophthalic Anhydride &gt
  • RSSYY(Perospirone Hydrochloride Hydrate)-7
  • 4-Acetamido-1,3-isobenzofurandione
  • 6296-53-3