ChemicalBook > CAS DataBase List > 3-O-Methylquercetin

3-O-Methylquercetin

Product Name
3-O-Methylquercetin
CAS No.
1486-70-0
Chemical Name
3-O-Methylquercetin
Synonyms
NSC 154016;3-Methylquercetol;3-Methoxyluteolin;Rutoside Trihydrate Impurity 8;3',4',5,7-Tetrahydroxy-3-methoxyflavone;TETRAHYDROXY-3-METHOXYFLAVONE, 3',4',5,7-(RG);2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-3-Methoxy-4H-chroMen-4-one;2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-3-Methoxy-4H-1-benzopyran-4-one;2-(3,4-Dihydroxyphenyl)-3-methoxy-5,7-dihydroxy-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one,2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-Methoxy-
CBNumber
CB81075557
Molecular Formula
C16H12O7
Formula Weight
316.26
MOL File
1486-70-0.mol
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3-O-Methylquercetin Property

Melting point:
275 °C
Boiling point:
643.0±55.0 °C(Predicted)
Density 
1.69±0.1 g/cm3(Predicted)
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form 
powder
pka
6.31±0.40(Predicted)
color 
Yellow
BRN 
324509
Stability:
Hygroscopic
LogP
2.020 (est)
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
90081
Product name
3-O-Methylquercetin
Purity
≥97% (HPLC)
Packaging
1mg
Price
$175.8
Updated
2024/03/01
Sigma-Aldrich
Product number
90081
Product name
3-O-Methylquercetin
Purity
≥97% (HPLC)
Packaging
5mg
Price
$713
Updated
2024/03/01
TRC
Product number
M326545
Product name
3-O-MethylQuercetin
Packaging
25mg
Price
$950
Updated
2021/12/16
Matrix Scientific
Product number
090947
Product name
2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-3-methoxy-4H-chromen-4-one
Purity
95+%
Packaging
250mg
Price
$1853
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
NUT0000023
Product name
3',4',5,7-TETRAHYDROXY-3-METHOXY FLAVONE
Purity
95.00%
Packaging
50MG
Price
$2194.5
Updated
2021/12/16
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3-O-Methylquercetin Chemical Properties,Usage,Production

Description

3-O-Methylquercetin is a metabolite in flavone and flavonol biosynthesis. It is a naturally occurring compound present in various plants, and was shown to have potent anticancer-promoting, antioxidant, antiallergy, and antimicrobial activity, and showed strong anti-viral activity inhibition of tomato ringspot virus.
3-O-Methylquercetin significantly inhibits cyclic adenosine monophosphate- (cAMP-) and cyclic guanosine monophosphate- (cGMP-) phosphodiesterase activity. It possess anti-inflammatory, bronchodilating properties and used in treatment of asthma. It suppresses the total inflammatory cells, tumor necrosis factor-α (TNF-α) and attenuates the production of interleukins.

Uses

A metabolite of the flavanoid Quercetin (Q509500) with inhibitory activity on lipopolysaccharide-induced activation of macrophage U937 cells.

Definition

ChEBI: A tetrahydroxyflavone having the 4-hydroxy groups located at the 3'- 4'- 5- and 7-positions as well as a methoxy group at the 2-position.

Biological Activity

3-O-Methylquercetin isolated from the herbs of Croton cascarilloides. It is a selective and competitive PDE3/PDE4 inhibitor,and inhibits PDE3 than PDE4 with a low K(m) value; it inhibits total cAMP- and cGMP-phosphodiesterase (PDE) of guinea pig trachealis at low concentrations.

Biochem/physiol Actions

3-O-Methylquercetin is a metabolite in flavone and flavonol biosynthesis. It is a naturally occurring compound present in various plants, and was shown to have potent anticancer-promoting, antioxidant, antiallergy, and antimicrobial activity, and showed strong anti-viral activity inhibition of tomato ringspot virus.

target

cAMP | PDE | IL Receptor | TNF-α | NOS | NO | Antifection

3-O-Methylquercetin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-O-Methylquercetin manufacturers

Career Henan Chemical Co
Product
3-O-Methylquercetin 1486-70-0
Price
US $1.00/KG
Min. Order
1KG
Purity
95-99%
Supply Ability
1ton
Release date
2020-01-03

1486-70-0, 3-O-MethylquercetinRelated Search:

ISORHAMNETIN-3-GLUCOSIDE Peltatoside Quercitrin Hyperoside QUERCETIN-3,7,3',4'-TETRAMETHYL ETHER Rutin 3,4'-DIMETHOXY-3',5,7-TRIHYDROXYFLAVONE CASTICIN Myricitrin ISORHAMNETIN-3-RUTINOSIDE 3,3',5,7 TETRAHYDROXY-4'-METHOXYFLAVONE 3,4',5,7-Tetrahydroxy-6-methoxyflavone ISOQUERCITRIN QUERCETIN-3-O-BETA-D-GLUCOPYRANOSYL-6''-ACETATE AVICULARIN 5-O-Methyl Quercetin;2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-5-Methoxy-4H-1-benzopyran-4-one 3,5,7,4'-TETRAHYDROXY-3'-METHOXYFLAVONE Rhamnetin

  • 3',4',5,7-Tetrahydroxy-3-methoxyflavone
  • 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-3-Methoxy-4H-1-benzopyran-4-one
  • 3-Methylquercetol
  • NSC 154016
  • 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-3-Methoxy-4H-chroMen-4-one
  • 2-(3,4-Dihydroxyphenyl)-3-methoxy-5,7-dihydroxy-4H-1-benzopyran-4-one
  • TETRAHYDROXY-3-METHOXYFLAVONE, 3',4',5,7-(RG)
  • 4H-1-Benzopyran-4-one,2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-Methoxy-
  • Rutoside Trihydrate Impurity 8
  • 3-Methoxyluteolin
  • 3OMethylquercetin,Phosphodiesterase (PDE),inhibit,3 O Methylquercetin,Inhibitor
  • 1486-70-0
  • Penta-substituted Flavones
  • Miscellaneous Natural Products
  • Aromatics
  • Heterocycles
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals