2-Pyrimidineacetic acid, ethyl ester (9CI)
- Product Name
- 2-Pyrimidineacetic acid, ethyl ester (9CI)
- CAS No.
- 63155-11-3
- Chemical Name
- 2-Pyrimidineacetic acid, ethyl ester (9CI)
- Synonyms
- Ethyl pyrimidine-2-acetate;Ethyl 2-(2-Pyrimidyl)acetate;2-Pyrimidineacetic acid ethyl ester;pyriMidin-2-yl-acetic acid ethyl ester;2-Pyrimidineacetic acid, ethyl ester (9CI);2-Pyrimidineacetic acid, ethyl ester (9CI) ISO 9001：2015 REACH
- CBNumber
- CB81081385
- Molecular Formula
- C8H10N2O2
- Formula Weight
- 166.18
- MOL File
- 63155-11-3.mol
2-Pyrimidineacetic acid, ethyl ester (9CI) Property
- Boiling point:
- 238 ºC
- Density
- 1.144
- Flash point:
- 98 ºC
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 0.93±0.13(Predicted)
- Appearance
- Light yellow to yellow Liquid
Safety
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- E932038
- Product name
- Ethyl2-(Pyrimidin-2-yl)acetate
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- OR965521
- Product name
- 2-Pyrimidineaceticacidethylester
- Purity
- 98%
- Packaging
- 1g
- Price
- $140
- Updated
- 2021/12/16
- Product number
- 072344
- Product name
- 2-Pyrimidineacetic acid ethyl ester
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $278
- Updated
- 2021/12/16
- Product number
- 4H58-1-UA
- Product name
- Ethyl 2-(pyrimidin-2-yl)acetate
- Purity
- 97.0%
- Packaging
- 250mg
- Price
- $290
- Updated
- 2021/12/16
- Product number
- 072344
- Product name
- 2-Pyrimidineacetic acid ethyl ester
- Purity
- 95+%
- Packaging
- 1g
- Price
- $599
- Updated
- 2021/12/16
2-Pyrimidineacetic acid, ethyl ester (9CI) Chemical Properties,Usage,Production
Synthesis
1722-12-9
105-53-3
63155-11-3
To a solution of diethyl malonate (6.65 mL, 43.65 mmol) in anhydrous DMF (30 mL) at -78 °C was slowly added sodium hydride (1.76 g, 52.38 mmol, 60% mineral oil dispersion). The reaction mixture was stirred at -78 °C for 10 min and then gradually warmed to room temperature, followed by dropwise addition of anhydrous DMF (3 mL) solution of 2-chloropyrimidine (1.0 g, 8.73 mmol). The reaction system was heated to 80 °C and maintained for 72 h. The reaction was then warmed up to 120 °C and continued for 18 h. The reaction was then completed. Upon completion of the reaction, the mixture was cooled to room temperature, the reaction was quenched with 1N HCl solution, neutralized with saturated aqueous NaHCO3 solution and extracted with ethyl acetate (3 x 30 mL). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: 0-100% ethyl acetate in hexane solution with gradient elution) to afford ethyl 2-pyrimidineacetate as a yellow-orange oil (1.34 g, 92% yield). Mass spectrometry (MS) showed the molecular ion peak m/z 167 (MH+).
References
[1] Patent: WO2014/25706, 2014, A1. Location in patent: Page/Page column 87
2-Pyrimidineacetic acid, ethyl ester (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Pyrimidineacetic acid, ethyl ester (9CI) manufacturers
- Product
- 2-Pyrimidineacetic acid, ethyl ester (9CI) 63155-11-3
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-12
- Product
- 2-Pyrimidineacetic acid, ethyl ester (9CI) 63155-11-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11
- Product
- 2-Pyrimidineacetic acid, ethyl ester (9CI) 63155-11-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09