ChemicalBook > CAS DataBase List > 2-Pyrimidineacetic acid, ethyl ester (9CI)

2-Pyrimidineacetic acid, ethyl ester (9CI)

Product Name
2-Pyrimidineacetic acid, ethyl ester (9CI)
CAS No.
63155-11-3
Chemical Name
2-Pyrimidineacetic acid, ethyl ester (9CI)
Synonyms
Ethyl pyrimidine-2-acetate;Ethyl 2-(2-Pyrimidyl)acetate;2-Pyrimidineacetic acid ethyl ester;pyriMidin-2-yl-acetic acid ethyl ester;2-Pyrimidineacetic acid, ethyl ester (9CI);2-Pyrimidineacetic acid, ethyl ester (9CI) ISO 9001：2015 REACH
CBNumber
CB81081385
Molecular Formula
C8H10N2O2
Formula Weight
166.18
MOL File
63155-11-3.mol
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2-Pyrimidineacetic acid, ethyl ester (9CI) Property

Boiling point:
238 ºC
Density 
1.144
Flash point:
98 ºC
storage temp. 
Sealed in dry,Room Temperature
pka
0.93±0.13(Predicted)
Appearance
Light yellow to yellow Liquid
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Safety

HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC
Product number
E932038
Product name
Ethyl2-(Pyrimidin-2-yl)acetate
Packaging
100mg
Price
$60
Updated
2021/12/16
Apolloscientific
Product number
OR965521
Product name
2-Pyrimidineaceticacidethylester
Purity
98%
Packaging
1g
Price
$140
Updated
2021/12/16
Matrix Scientific
Product number
072344
Product name
2-Pyrimidineacetic acid ethyl ester
Purity
95+%
Packaging
250mg
Price
$278
Updated
2021/12/16
SynQuest Laboratories
Product number
4H58-1-UA
Product name
Ethyl 2-(pyrimidin-2-yl)acetate
Purity
97.0%
Packaging
250mg
Price
$290
Updated
2021/12/16
Matrix Scientific
Product number
072344
Product name
2-Pyrimidineacetic acid ethyl ester
Purity
95+%
Packaging
1g
Price
$599
Updated
2021/12/16
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2-Pyrimidineacetic acid, ethyl ester (9CI) Chemical Properties,Usage,Production

Synthesis

1722-12-9

105-53-3

63155-11-3

To a solution of diethyl malonate (6.65 mL, 43.65 mmol) in anhydrous DMF (30 mL) at -78 °C was slowly added sodium hydride (1.76 g, 52.38 mmol, 60% mineral oil dispersion). The reaction mixture was stirred at -78 °C for 10 min and then gradually warmed to room temperature, followed by dropwise addition of anhydrous DMF (3 mL) solution of 2-chloropyrimidine (1.0 g, 8.73 mmol). The reaction system was heated to 80 °C and maintained for 72 h. The reaction was then warmed up to 120 °C and continued for 18 h. The reaction was then completed. Upon completion of the reaction, the mixture was cooled to room temperature, the reaction was quenched with 1N HCl solution, neutralized with saturated aqueous NaHCO3 solution and extracted with ethyl acetate (3 x 30 mL). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: 0-100% ethyl acetate in hexane solution with gradient elution) to afford ethyl 2-pyrimidineacetate as a yellow-orange oil (1.34 g, 92% yield). Mass spectrometry (MS) showed the molecular ion peak m/z 167 (MH+).

References

[1] Patent: WO2014/25706, 2014, A1. Location in patent: Page/Page column 87

2-Pyrimidineacetic acid, ethyl ester (9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Pyrimidineacetic acid, ethyl ester (9CI) manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2-Pyrimidineacetic acid, ethyl ester (9CI) 63155-11-3
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-12
Zhuozhou Wenxi import and Export Co., Ltd
Product
2-Pyrimidineacetic acid, ethyl ester (9CI) 63155-11-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11
Zhuozhou Wenxi import and Export Co., Ltd
Product
2-Pyrimidineacetic acid, ethyl ester (9CI) 63155-11-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

63155-11-3, 2-Pyrimidineacetic acid, ethyl ester (9CI)Related Search:

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  • 2-Pyrimidineacetic acid, ethyl ester (9CI)
  • 2-Pyrimidineacetic acid ethyl ester
  • Ethyl 2-(2-Pyrimidyl)acetate
  • pyriMidin-2-yl-acetic acid ethyl ester
  • Ethyl pyrimidine-2-acetate
  • 2-Pyrimidineacetic acid, ethyl ester (9CI) ISO 9001：2015 REACH
  • 63155-11-3
  • PYRIMIDINE
  • Heterocycle-Pyrimidine series