1-(3-HYDROXYPROPYL)-PYRROLIDINE

Uses

Product Name: 1-(3-HYDROXYPROPYL)-PYRROLIDINE
CAS No.: 19748-66-4
Chemical Name: 1-(3-HYDROXYPROPYL)-PYRROLIDINE
Synonyms: BRN 0103382;CHEMBRDG-BB 4012899;1-PYRROLIDINEPROPANOL;3-(1-Pyrrolidyl)-1-propanol;3-1-pyrrolidinylpropan-1-ol;3-(1-Pyrrolidinyl)-1-propanol;1-(3-HYDROXYPROPYL)-PYRROLIDINE;4-Piperidinepropanol,9-hydroxy-;1-(3-hydroxypropyl)-pyrrolidlne;gamma-Pyrrolidinopropanol [German]
CBNumber: CB8109134
Molecular Formula: C7H15NO
Formula Weight: 129.2
MOL File: 19748-66-4.mol

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1-(3-HYDROXYPROPYL)-PYRROLIDINE Property

Boiling point:: 98 °C(Press: 18 Torr)
Density: 0.983±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 15.02±0.10(Predicted)
Appearance: Colorless to light yellow Liquid
InChI: InChI=1S/C7H15NO/c9-7-3-6-8-4-1-2-5-8/h9H,1-7H2
InChIKey: ZMJQROKRSPSLFH-UHFFFAOYSA-N
SMILES: N1(CCCO)CCCC1

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: P3054
Product name: 3-(Pyrrolidin-1-yl)propan-1-ol
Packaging: 1G
Price: $51
Updated: 2025/07/31

TCI Chemical

Product number: P3054
Product name: 3-(Pyrrolidin-1-yl)propan-1-ol
Packaging: 5G
Price: $153
Updated: 2025/07/31

AK Scientific

Product number: J55155
Product name: 3-(Pyrrolidin-1-yl)propan-1-ol
Packaging: 5g
Price: $235
Updated: 2021/12/16

ChemScene

Product number: CS-W005320
Product name: 3-(Pyrrolidin-1-yl)propan-1-ol
Purity: 98.95%
Packaging: 5g
Price: $237
Updated: 2021/12/16

Matrix Scientific

Product number: 080698
Product name: 3-Pyrrolidin-1-ylpropan-1-ol
Packaging: 5g
Price: $237
Updated: 2021/12/16

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1-(3-HYDROXYPROPYL)-PYRROLIDINE Chemical Properties,Usage,Production

Uses

1-(3-hydroxypropyl)pyrrolidine can be used as a synthetic intermediate in pharmaceuticals and chemicals.

Synthesis

123-75-1

627-18-9

19748-66-4

Potassium carbonate (269 g, 1.95 mol) and pyrrolidine (200 mL, 2.40 mol) were sequentially added to a tetrahydrofuran solution (500 mL) of 3-bromo-1-propanol (200 g, 1.44 mol) at 0 °C. The reaction mixture was stirred and reacted at room temperature for 15 h. After the reaction, ethyl acetate (500 mL) was added to dilute the mixture and stirring was continued for 1 h. The reaction mixture was then stirred at room temperature for 1 h. The reaction mixture was filtered through a diatomaceous earth pad and the diatomaceous earth pad was washed well with ethyl acetate. The filtrate and washings were combined and concentrated under reduced pressure to remove the solvent. To the concentrated residue was added ethyl acetate (500 mL), stirred for 1 hour and then filtered through diatomaceous earth again. The filtrate was concentrated under reduced pressure and purified by reduced pressure distillation (boiling point: 62 °C, 1 mmHg) to give 3-(1-pyrrolidinyl)-1-propanol (156 g, 95% yield). The product was characterized by 1H NMR (400 MHz, CDCl3): δ 1.69-1.78 (6H, m), 2.53-2.59 (4H, m), 2.73 (2H, t, J = 5.6 Hz), 3.81 (2H, t, J = 5.4 Hz), 5.58 (1H, brs).

References

[1] Journal of Medicinal Chemistry, 2008, vol. 51, # 15, p. 4780 - 4789
[2] Patent: EP1852423, 2007, A1. Location in patent: Page/Page column 6; 14
[3] Patent: WO2009/121812, 2009, A1. Location in patent: Page/Page column 72-73
[4] Journal of Medicinal Chemistry, 2017, vol. 60, # 8, p. 3275 - 3288
[5] Patent: WO2018/118852, 2018, A1. Location in patent: Paragraph 0072

1-(3-HYDROXYPROPYL)-PYRROLIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(3-HYDROXYPROPYL)-PYRROLIDINE Suppliers

China 96 India 2 Italy 1 Ukraine 2 United Kingdom 1 United States 20 Global 122

Anhui Nature Pharmaceutical Co., Ltd.

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View Lastest Price from 1-(3-HYDROXYPROPYL)-PYRROLIDINE manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 1-(3-HYDROXYPROPYL)-PYRROLIDINE 19748-66-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 10000KGS
Release date: 2025-05-08

Shaanxi Dideu Medichem Co. Ltd

Product: 3-(Pyrrolidin-1-yl)propan-1-ol 19748-66-4
Price: US $0.00-0.00/KG
Min. Order: 1g
Purity: 99%
Supply Ability: 2000tons
Release date: 2019-12-31

Career Henan Chemical Co

Product: 1-(3-HYDROXYPROPYL)-PYRROLIDINE 19748-66-4
Price: US $8.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10tons
Release date: 2018-12-24

19748-66-4, 1-(3-HYDROXYPROPYL)-PYRROLIDINERelated Search:

BRADYKININ procyclidine T-KININ BNP-32 (PORCINE) CASTANOSPERMINE 3-(2,5-dioxopyrrolidin-1-yl)propanoic acid ARG-PRO-PRO-GLY-PHE-SER-PRO-LEU (P-CHLORO-PHE5,8)-BRADYKININ H-ARG-PRO-PRO-GLY-PHE-SER-PRO-OH ACETATE SALT H-SER-PRO-OH GLIOTOXIN 1-(3-HYDROXYPROPYL)-2-PYRROLIDONE ARG-PRO-PRO-GLY-PHE-SER-PRO-PHE H-PRO-PRO-GLY-PHE-SER-PRO-OH 3-PYRROLIDINO-1,2-PROPANEDIOL ARG-PRO-HYP-GLY-PHE-SER-PRO-PHE-ARG PRO-PRO-GLY-PHE-SER-PRO-PHE-ARG ARG-PRO-GLY-PHE-SER-PRO-PHE-ARG

CHEMBRDG-BB 4012899

1-PYRROLIDINEPROPANOL

1-PYRROLIDINEPROPANOL [ALSO: 1-(3-HYDROXYPROPYL)PYRROLIDINE]

3-pyrrolidin-1-ylpropan-1-ol(SALTDATA: 0.3H2O)

3-(1-Pyrrolidyl)-1-propanol

1-(3-HYDROXYPROPYL)-PYRROLIDINE

4-20-00-00118 (Beilstein Handbook Reference)

BRN 0103382

gamma-Pyrrolidinopropanol [German]

3-1-pyrrolidinylpropan-1-ol

1-(3-Hydroxypropyl)-pyrrolidine hydrochloride

4-Benzothiazolecarboxylicacid,2-amino-4,5,6,9-tetrahydro-,ethylester

4-Piperidinepropanol,9-hydroxy-

1-Propanol,3-[(tetrahydro-2H-pyran-7-yl)oxy]-

1-(3-hydroxypropyl)-pyrrolidlne

3-(1-Pyrrolidinyl)-1-propanol

19748-66-4