ChemicalBook > CAS DataBase List > procyclidine
procyclidine
- Product Name
- procyclidine
- CAS No.
- 77-37-2
- Chemical Name
- procyclidine
- Synonyms
- Vagosin;Kemadrine;Tricyclamol;procyclidine;procyclidine USP/EP/BP;1-Pyrrolidinepropanol, α-cyclohexyl-α-phenyl-;α-Cyclohexyl-α-phenyl-1-pyrrolidine-1-propanol;1-cyclohexyl-1-phenyl-3-pyrrolidin-1-ylpropan-1-ol;1-cyclohexyl-1-phenyl-3-pyrrolidin-1-yl-propan-1-ol hydrochloride
- CBNumber
- CB2875688
- Molecular Formula
- C19H29NO
- Formula Weight
- 287.44
- MOL File
- 77-37-2.mol
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procyclidine Property
- Melting point:
- 85.5-86.5°
- Boiling point:
- 429.73°C (rough estimate)
- Density
- 0.9954 (rough estimate)
- refractive index
- 1.5180 (estimate)
- pka
- 14.21±0.29(Predicted)
- Water Solubility
- 1.055mg/L(22.5 ºC)
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Safety
- Hazardous Substances Data
- 77-37-2(Hazardous Substances Data)
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N-Bromosuccinimide Price
American Custom Chemicals Corporation
- Product number
- API0008986
- Product name
- PROCYCLIDINE
- Purity
- 95.00%
- Packaging
- 10G
- Price
- $1236.09
- Updated
- 2021/12/16
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procyclidine Chemical Properties,Usage,Production
Uses
Antiparkinsonian; relaxant (skeletal muscle).
Definition
ChEBI: A tertiary alcohol that consists of propan-1-ol substituted by a cyclohexyl and a phenyl group at position 1 and a pyrrolidin-1-yl group at position 3.
brand name
Kemadrin (Monarch).
Synthesis
Procyclidine, 1-cyclohexyl-1-phenyl-3-pirrolidinopropan-1-ol (10.2.3), is synthesized in the exact same manner, except beginning with 2-(1-pyrrolidino) propiophenone [28–32].
in vivo
Procyclidine (subcutaneous injection, 0.3-6.0 mg/kg) in combination with physostigmine (PhS) increases protection in a dose-dependent manner in rats and guinea pigs infected with soman and can prevent seizures altogether[1].
| Animal Model: | Male Sprague-Dawley rats, Dunkin-Hartley male guinea pigs[1] |
| Dosage: | 0.3-6.0 mg/kg |
| Administration: | Subcutaneous injection; once |
| Result: | Increased protection, resulting in 1.92, 2.24, 3.95 and 5.07 fold in rats, 3.00, 3.25, 4.50 and 4.70 fold in guinea pigs at the doses of 0.3, 1.0, 3.0 or 6.0 mg/kg, respectively. Protected the neurological integrity of the brain and prevented Soman-induced severe brain damage in the hippocampus, cortex, amygdala and thalamus. |
IC 50
NMDA Receptor
procyclidine Preparation Products And Raw materials
Raw materials
Preparation Products
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