(R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one

Product Name: (R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one
CAS No.: 145589-03-3
Chemical Name: (R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one
Synonyms: (R)-3-(3-Methylbutanoyl)-4-;-4-Benzyl-3-(3-methylbutanoyl);(4R)-4-Benzyl-3-isovaleryloxazolidin-2-one;3-isovaleroyl-4(R)-benzyl-oxazolidin-2-one;4R-Benzyl-3-(3-Methylbutyryl)oxazolidin-2-one;(R)-3-(3-methylbutanoyl)-4-benzyloxazolidin-2-one;(R)-4-benzyl-3-(3-Methylbutanoyl)oxazolidin-2-one;(4R)-4-Benzyl-3-(3-methyl-butyryl)-oxazolidin-2-one;(4R)-4-benzyl-3-(3-Methylbutanoyl)-1,3-oxazolidin-2-one;(4R)-3-(3-Methyl-1-oxobutyl)-4-(phenylMethyl)-2-oxazolidinone
CBNumber: CB81094208
Molecular Formula: C15H19NO3
Formula Weight: 261.32
MOL File: 145589-03-3.mol

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(R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one Property

Boiling point:: 412.9±14.0 °C(Predicted)
Density: 1.152
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform, Dichloromethane, Ethyl Acetate
pka: -2.33±0.40(Predicted)
form: Solid
color: White
optical activity: Consistent with structure
InChI: InChI=1S/C15H19NO3/c1-11(2)8-14(17)16-13(10-19-15(16)18)9-12-6-4-3-5-7-12/h3-7,11,13H,8-10H2,1-2H3/t13-/m1/s1
InChIKey: JHGXEUXQJIKZMY-CYBMUJFWSA-N
SMILES: O1C[C@@H](CC2=CC=CC=C2)N(C(=O)CC(C)C)C1=O

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Safety

Safety Statements: 24/25
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M294335
Product name: (R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one
Packaging: 1g
Price: $530
Updated: 2021/12/16

Matrix Scientific

Product number: 131940
Product name: (R)-4-Benzyl-3-(3-methylbutanoyl)oxazolidin-2-one
Purity: 97%
Packaging: 5g
Price: $605
Updated: 2021/12/16

AK Scientific

Product number: 7200AA
Product name: (R)-4-Benzyl-3-(3-methylbutanoyl)oxazolidin-2-one
Packaging: 5g
Price: $735
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CCH0001414
Product name: (R)-3-(3-METHYLBUTANOYL)-4-BENZYLOXAZOLIDIN-2-ONE
Purity: 95.00%
Packaging: 250MG
Price: $739.2
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CCH0001414
Product name: (R)-3-(3-METHYLBUTANOYL)-4-BENZYLOXAZOLIDIN-2-ONE
Purity: 95.00%
Packaging: 1G
Price: $892.5
Updated: 2021/12/16

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(R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

(R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one (cas# 145589-03-3) is a compound useful in organic synthesis.

Synthesis

90719-32-7

108-12-3

145589-03-3

GENERAL STEPS: A dichloromethane (100 ml) solution of 4-dimethylaminopyridine (2.55 g, 21.3 mmol) and triethylamine (46.9 ml, 340.8 mmol) was slowly added to a dichloromethane (300 ml) solution of (S)-4-benzyl-2-oxazolidinone (37.7 g, 213 mmol) at 0 °C. Subsequently, a solution of isovaleryl chloride (33.75 ml, 207 mmol) in dichloromethane (50 ml) was added dropwise while keeping the internal temperature below 10 °C. The reaction mixture was stirred at 10 °C for 30 min and then filtered to remove the formed salt. Water (100 ml) was added to the filtrate for phase separation. The organic phase was washed sequentially with water (100 ml) and brine (100 ml), dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give 53 g of a yellow oily product, which solidified to a solid on standing (95% yield). The product was characterized by 1H NMR (300 MHz, CDCl3, 298 K) and 13C NMR (75 MHz, CDCl3, 298 K) and confirmed to be the target compound 3-isopentanoyl-4(R)-benzyl-2-oxazolidinone.

References

[1] Helvetica Chimica Acta, 2012, vol. 95, # 10, p. 1937 - 1945,9
[2] Patent: WO2011/151442, 2011, A2. Location in patent: Page/Page column 24
[3] Patent: US2013/71899, 2013, A1. Location in patent: Paragraph 0124-0127
[4] Journal of Medicinal Chemistry, 2016, vol. 59, # 23, p. 10530 - 10548
[5] Organic Process Research and Development, 2015, vol. 19, # 6, p. 611 - 617

(R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one Suppliers

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View Lastest Price from (R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one manufacturers

Career Henan Chemical Co

Product: (R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one 145589-03-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-09

145589-03-3, (R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-oneRelated Search:

(R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE 3-(4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-4-methyl-hexanoic acid tert-butyl ester (3S,4R)-4-BENZYL-3-(3-METHYLPENTANOYL)-OXAZOLIDIN-2-ONE (N-ACETYL)-(4R)-BENZYL-2-OXAZOLIDINONE (R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one

(R)-3-(3-methylbutanoyl)-4-benzyloxazolidin-2-one

3-isovaleroyl-4(R)-benzyl-oxazolidin-2-one

(4R)-4-benzyl-3-(3-Methylbutanoyl)-1,3-oxazolidin-2-one

3-(3-Methyl-1-oxobutyl)-4-(p henylMethyl)-, (R)-2-Oxazolidinone

(4R)-3-(3-Methyl-1-oxobutyl)-4-(phenylMethyl)-2-oxazolidinone

(4R)-4-Benzyl-3-isovaleryloxazolidin-2-one

4R-Benzyl-3-(3-Methylbutyryl)oxazolidin-2-one

Oxazolidinone, 3-(3-methyl-1-oxobutyl)-4-(phenylmethyl)-, (4R)-

2-Oxazolidinone, 3-(3-Methyl-1-oxobutyl)-4-(phenylMethyl)-, (R)-

2-Oxazolidinone,3-(3-Methyl-1-oxobutyl)-4-(phenylMethyl)-, (4R)-

-4-Benzyl-3-(3-methylbutanoyl)

(R)-4-benzyl-3-(3-Methylbutanoyl)oxazolidin-2-one

(4R)-4-Benzyl-3-(3-methyl-butyryl)-oxazolidin-2-one

(R)-3-(3-Methylbutanoyl)-4-

145589-03-3

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