ChemicalBook > CAS DataBase List > (R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one

(R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one

Product Name: (R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one
CAS No.: 145589-03-3
Chemical Name: (R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one
Synonyms: (R)-3-(3-Methylbutanoyl)-4-;-4-Benzyl-3-(3-methylbutanoyl);(4R)-4-Benzyl-3-isovaleryloxazolidin-2-one;3-isovaleroyl-4(R)-benzyl-oxazolidin-2-one;4R-Benzyl-3-(3-Methylbutyryl)oxazolidin-2-one;(R)-3-(3-methylbutanoyl)-4-benzyloxazolidin-2-one;(R)-4-benzyl-3-(3-Methylbutanoyl)oxazolidin-2-one;(4R)-4-Benzyl-3-(3-methyl-butyryl)-oxazolidin-2-one;(4R)-4-benzyl-3-(3-Methylbutanoyl)-1,3-oxazolidin-2-one;(4R)-3-(3-Methyl-1-oxobutyl)-4-(phenylMethyl)-2-oxazolidinone
CBNumber: CB81094208
Molecular Formula: C15H19NO3
Formula Weight: 261.32
MOL File: 145589-03-3.mol

Less

(R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one Property

Boiling point:: 412.9±14.0 °C(Predicted)
Density: 1.152
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform, Dichloromethane, Ethyl Acetate
pka: -2.33±0.40(Predicted)
form: Solid
color: White
optical activity: Consistent with structure
InChI: InChI=1S/C15H19NO3/c1-11(2)8-14(17)16-13(10-19-15(16)18)9-12-6-4-3-5-7-12/h3-7,11,13H,8-10H2,1-2H3/t13-/m1/s1
InChIKey: JHGXEUXQJIKZMY-CYBMUJFWSA-N
SMILES: O1C[C@@H](CC2=CC=CC=C2)N(C(=O)CC(C)C)C1=O

Less

Safety

Safety Statements: 24/25
HS Code: 29349990

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

TRC

Product number: M294335
Product name: (R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one
Packaging: 1g
Price: $530
Updated: 2021/12/16

Matrix Scientific

Product number: 131940
Product name: (R)-4-Benzyl-3-(3-methylbutanoyl)oxazolidin-2-one
Purity: 97%
Packaging: 5g
Price: $605
Updated: 2021/12/16

AK Scientific

Product number: 7200AA
Product name: (R)-4-Benzyl-3-(3-methylbutanoyl)oxazolidin-2-one
Packaging: 5g
Price: $735
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CCH0001414
Product name: (R)-3-(3-METHYLBUTANOYL)-4-BENZYLOXAZOLIDIN-2-ONE
Purity: 95.00%
Packaging: 250MG
Price: $739.2
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CCH0001414
Product name: (R)-3-(3-METHYLBUTANOYL)-4-BENZYLOXAZOLIDIN-2-ONE
Purity: 95.00%
Packaging: 1G
Price: $892.5
Updated: 2021/12/16

Less

(R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

(R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one (cas# 145589-03-3) is a compound useful in organic synthesis.

Synthesis

90719-32-7

108-12-3

145589-03-3

GENERAL STEPS: A dichloromethane (100 ml) solution of 4-dimethylaminopyridine (2.55 g, 21.3 mmol) and triethylamine (46.9 ml, 340.8 mmol) was slowly added to a dichloromethane (300 ml) solution of (S)-4-benzyl-2-oxazolidinone (37.7 g, 213 mmol) at 0 °C. Subsequently, a solution of isovaleryl chloride (33.75 ml, 207 mmol) in dichloromethane (50 ml) was added dropwise while keeping the internal temperature below 10 °C. The reaction mixture was stirred at 10 °C for 30 min and then filtered to remove the formed salt. Water (100 ml) was added to the filtrate for phase separation. The organic phase was washed sequentially with water (100 ml) and brine (100 ml), dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give 53 g of a yellow oily product, which solidified to a solid on standing (95% yield). The product was characterized by 1H NMR (300 MHz, CDCl3, 298 K) and 13C NMR (75 MHz, CDCl3, 298 K) and confirmed to be the target compound 3-isopentanoyl-4(R)-benzyl-2-oxazolidinone.

References

[1] Helvetica Chimica Acta, 2012, vol. 95, # 10, p. 1937 - 1945,9
[2] Patent: WO2011/151442, 2011, A2. Location in patent: Page/Page column 24
[3] Patent: US2013/71899, 2013, A1. Location in patent: Paragraph 0124-0127
[4] Journal of Medicinal Chemistry, 2016, vol. 59, # 23, p. 10530 - 10548
[5] Organic Process Research and Development, 2015, vol. 19, # 6, p. 611 - 617

(R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one Preparation Products And Raw materials

Raw materials

Preparation Products

Less

(R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one Suppliers

Canada 1 CHINA 77 India 4 United States 6 Global 88

Nantong Huakang Medicine Technology Co.,Ltd.

Tel: 18912220755
Email: 249125764@qq.com
Country: China
ProdList: 21
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Shanghai Sinch Parmaceuticals Tech. Co. Ltd.

Tel: +86-21-54098501
Fax: +86-21-54096319
Email: sales@sinch.com.cn
Country: China
ProdList: 11598
Advantage: 64

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14101
Advantage: 59

Shanghai Longsheng chemical Co.,Ltd.

Tel: 021-58099652-8005 13585536065
Fax: 021-58099609
Email: bin.wu@shlschem.com
Country: China
ProdList: 9883
Advantage: 59

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Shanghai Sphchem Co., Ltd.

Tel: 021-56491756 13512199871
Fax: 021-5649-1756
Email: 2819742715@qq.com
Country: China
ProdList: 3997
Advantage: 55

Chengdu Ai Keda Chemical Technology Co., Ltd.

Tel: 4008-755-333 18080918076
Fax: 028-86757656
Email: 800078821@qq.com
Country: China
ProdList: 9718
Advantage: 55

Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
Fax: +86 21 50676805
Country: China
ProdList: 9891
Advantage: 58

AstaTech (Chengdu) Pharma. Co., Ltd.

Tel: 15928766785 15928766785
Fax: QQ961458712
Email: wupengcheng@astatech.cn
Country: China
ProdList: 1987
Advantage: 55

Eastbang Pharmaceuticals Technology Co., Ltd.

Tel: +86 (20) 28996708,29078958,28139708,29076128,28133708,28139728,28139738,28133718,021-31663278,021-31663578,021-60538387
Fax: +86 (20) 39218032
Country: China
ProdList: 454
Advantage: 58

Chengdu HuaXia Chemical Reagent Co. Ltd

Tel: 400-1166-196 13458535857
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 13350
Advantage: 58

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15178
Advantage: 58

Suzhou yacoo science co.,Ltd

Tel: 0512-87182056 18013166090
Fax: 0512-87182056
Email: lingling.qi@yacoo.com.cn
Country: China
ProdList: 6295
Advantage: 60

Shanghai HuanChuan Industry Co.,Ltd.

Tel: 021-61478794
Fax: 021-61478794
Email: sales@hcshhai.com
Country: China
ProdList: 9793
Advantage: 50

Shanghai Na Qian Chemical Technology Co. Ltd.

Tel: 13598610367
Fax: QQ:2468833170
Email: 2841375912@qq.com
Country: China
ProdList: 2789
Advantage: 52

Cool Pharm, Ltd

Tel: 021-60455363 18019463053
Fax: 50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12346
Advantage: 58

Chizhou Kailong Import and Export Trade Co., Ltd.

Tel
Fax: -
Email: xg01_gj@163.com
Country: China
ProdList: 9484
Advantage: 50

AN PharmaTech Co Ltd

Tel: 86(21)68097365
Fax: 86(21)33321566
Email: sales@anpharma.net
Country: China
ProdList: 4891
Advantage: 55

Tongling HengYou Biotechnology Co., Ltd.

Tel: 021-50426030 13856289449
Fax: 021-50426030
Email: 2630597085@qq.com
Country: China
ProdList: 1889
Advantage: 55

SanoChem (Chengdu) Tech. Co., Ltd.

Tel: 28-87999436 02887999436
Fax: QQ:2746983436
Email: sales@sano-chem.com
Country: China
ProdList: 3795
Advantage: 55

Shanghai Chiral bio-compound co., Ltd.

Tel: 021-5068 3667/17749785980/1029026415; 17749785980
Fax: 021-50683667
Email: 1029026415@qq.com
Country: China
ProdList: 3397
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Shanghai Changyan Chem & Tech Co., Ltd.

Tel: 021-20242659 18930833303
Fax: +86 (21) 2024-2659
Email: Sales@changyanchem.cn
Country: China
ProdList: 5001
Advantage: 55

Shandong Xiya Chemical Co., Ltd.

Tel: 4009903999 13395398332
Fax: 0539-6365991
Email: sales@xiyashiji.com
Country: China
ProdList: 20794
Advantage: 60

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Shandong Ono Chemical Co., Ltd.

Tel: 0539-6362799 20）
Fax: 0539-6362799（To 20）
Country: China
ProdList: 9998
Advantage: 58

Aikon International Limited

Tel: 025-58859352 18068836627
Fax: (5)02557626880
Email: dt3@aikonchem.com
Country: China
ProdList: 15493
Advantage: 58

Alchemist-pharm chemical Technology Co. Ltd.

Tel: 0371-67991738 13783628208
Fax: QQ 412703949
Email: carl@alchemist-pharm.com
Country: China
ProdList: 1872
Advantage: 58

Nanjing crow LuNing pharmaceutical technology co., LTD

Tel: 13382066392
Country: CHINA
ProdList: 4877
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57422
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: +86-0551-65418684 +8618949823763
Fax: 0086-551-65418684
Email: sales@tnjchem.com
Country: China
ProdList: 25356
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: +86-0571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: China
ProdList: 52846
Advantage: 58

SIMAGCHEM CORP

Tel: +86-5922680277 +86-13806087780
Email: sale@simagchem.com
Country: China
ProdList: 17346
Advantage: 58

Changzhou Yinghao Technology Development Co., Ltd

Tel: 15151934985
Email: sales@yingsapharm.com
Country: China
ProdList: 5174
Advantage: 58

Guizhou Yituo Chemical Technology Co., Ltd

Tel: 18628235590
Fax: QQ:444176500
Email: wuliming@yituochem.cn
Country: China
ProdList: 1242
Advantage: 58

Qi Qi hang Biotechnology Co., Ltd.

Tel: 18151111370
Email: 1046215251@qq.com
Country: China
ProdList: 5999
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49975
Advantage: 58

Shanghai Kaiwei Chemical Technology Co., Ltd.

Tel: 021-58461859 15821823057
Email: service@aiviche.com
Country: China
ProdList: 49312
Advantage: 58

career henan chemical co

Tel: +86-0371-86658258 +8613203830695
Fax: 0086-371-86658258
Email: factory@coreychem.com
Country: China
ProdList: 29798
Advantage: 58

Taizhou Nanfeng Pharmaceutical Research Institute

Tel: nanfengdrug@163.com; 18616377689
Email: nanfengdrug@163.com
Country: China
ProdList: 20009
Advantage: 58

Henan Weitesi Chemical Technology Co. LTD

Tel: 0371-0371-55135753 18003832934
Fax: QQ：2853979818
Email: 2853979818@qq.com
Country: China
ProdList: 9991
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 13675144456
Fax: 025-85563444
Email: sean.lv@synzest.com
Country: China
ProdList: 11438
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44894
Advantage: 58

Hubei Co-prosperity Medicine Technonlogy Co., Ltd

Tel: 2383948258 19172820304
Email: 2383948258@qq.com
Country: China
ProdList: 12987
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 4008210725
Email: malulu@leyan.com
Country: China
ProdList: 40000
Advantage: 58

Beijing Stronger Science Co., Ltd.

Tel: 0531-88924771 15614660963
Email: elsa.hang@strongerscience.com
Country: China
ProdList: 10623
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-6005915
Email: sales@picasso-e.com
Country: China
ProdList: 39665
Advantage: 58

Less

View Lastest Price from (R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one manufacturers

Career Henan Chemical Co

Product: (R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one 145589-03-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-09

145589-03-3, (R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-oneRelated Search:

(R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE 3-(4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-4-methyl-hexanoic acid tert-butyl ester (3S,4R)-4-BENZYL-3-(3-METHYLPENTANOYL)-OXAZOLIDIN-2-ONE (N-ACETYL)-(4R)-BENZYL-2-OXAZOLIDINONE (R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one

(R)-3-(3-methylbutanoyl)-4-benzyloxazolidin-2-one

3-isovaleroyl-4(R)-benzyl-oxazolidin-2-one

(4R)-4-benzyl-3-(3-Methylbutanoyl)-1,3-oxazolidin-2-one

3-(3-Methyl-1-oxobutyl)-4-(p henylMethyl)-, (R)-2-Oxazolidinone

(4R)-3-(3-Methyl-1-oxobutyl)-4-(phenylMethyl)-2-oxazolidinone

(4R)-4-Benzyl-3-isovaleryloxazolidin-2-one

4R-Benzyl-3-(3-Methylbutyryl)oxazolidin-2-one

Oxazolidinone, 3-(3-methyl-1-oxobutyl)-4-(phenylmethyl)-, (4R)-

2-Oxazolidinone, 3-(3-Methyl-1-oxobutyl)-4-(phenylMethyl)-, (R)-

2-Oxazolidinone,3-(3-Methyl-1-oxobutyl)-4-(phenylMethyl)-, (4R)-

-4-Benzyl-3-(3-methylbutanoyl)

(R)-4-benzyl-3-(3-Methylbutanoyl)oxazolidin-2-one

(4R)-4-Benzyl-3-(3-methyl-butyryl)-oxazolidin-2-one

(R)-3-(3-Methylbutanoyl)-4-

145589-03-3

Aromatics

Chiral Reagents

Miscellaneous Reagents