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Pirmenol

Product Name
Pirmenol
CAS No.
68252-19-7
Chemical Name
Pirmenol
Synonyms
(±)-Pirmenol;Pirmenol (Cl-845);Pirmenol, 10 mM in DMSO;2-Pyridinemethanol, a-[3-(2,6-dimethyl-1-piperidinyl)propyl]-a-phenyl-, cis-;rel-4-((2S,6R)-2,6-Dimethylpiperidin-1-yl)-1-phenyl-1-(pyridin-2-yl)butan-1-ol;2-Pyridinemethanol, a-[3-(2,6-dimethyl-1-piperidinyl)propyl]-a-phenyl-, cis-(+-)-;2-Pyridinemethanol, α-[3-[(2R,6S)-2,6-dimethyl-1-piperidinyl]propyl]-α-phenyl-, rel-;2-Pyridinemethanol, a-[3-[(2R,6S)-2,6-dimethyl-1-piperidinyl]propyl]-a-phenyl-, rel- (9CI)
CBNumber
CB81116681
Molecular Formula
C22H30N2O
Formula Weight
338.49
MOL File
68252-19-7.mol
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Pirmenol Property

Melting point:
70-71°
Boiling point:
499.6±45.0 °C(Predicted)
Density 
1.046±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 2mg/mL,DMSO: 5mg/mL,Ethanol: 10mg/mL,Ethanol:PBS (pH 7.2) (1:5): 0.16mg/mL
form 
A solid
pka
12.66±0.29(Predicted)
color 
White to v. dark grey
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML3555
Product name
Pirmenol
Purity
≥98% (HPLC)
Packaging
5 mg
Price
$79.51
Updated
2025/07/31
Sigma-Aldrich
Product number
SML3555
Product name
Pirmenol
Purity
≥98% (HPLC)
Packaging
25 mg
Price
$269
Updated
2025/07/31
Cayman Chemical
Product number
29042
Product name
Pirmenol
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
29042
Product name
Pirmenol
Packaging
25mg
Price
$573
Updated
2024/03/01
Cayman Chemical
Product number
29042
Product name
Pirmenol
Packaging
5mg
Price
$151
Updated
2024/03/01
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Pirmenol Chemical Properties,Usage,Production

Uses

Cardiac depressant (anti-arrhythmic).

Definition

ChEBI: Pirmenol is a racemate.

brand name

Pirmavar (Parke-Davis).

Biological Activity

Pirmenol is an antiarrhythmic agent class Ia th at exhibit long half-life and low toxicities. Pirmenol suppresses premature ventricular contractions in human studies.

in vivo

Pirmenol (2.5 and 5 mg/kg, p.o.) is effective against the arrhythmias in conscious, coronary artery ligated dogs[4].
Pirmenol (rats) shows LD50s of 359.9 mg/kg (p.o), 23.6 mg/kg (i.v.)[2].
Pirmenol (mice) shows LD50s of 215.5 mg/kg (p.o), 20.8 mg/kg (i.v.)[2].

Animal Model:Conscious, coronary artery ligated dogs[4]
Dosage:Oral administration (p.o.)
Administration:2.5 and 5 mg/kg
Result:Restored normal sinus rhythm, and showed a long duration of activity, wide safety margin.

Pirmenol Preparation Products And Raw materials

Raw materials

Preparation Products

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Pirmenol Suppliers

China 31 United Kingdom 1 United States 6 Global 38
Shanghai EFE Biological Technology Co., Ltd.
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Shanghai YuanYe Biotechnology Co., Ltd.
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021-61312847; 18021002903
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ShangHai Biochempartner Co.,Ltd
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177-54423994 17754423994
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Shanghai Chaolan Chemical Technology Center
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021-QQ：65489617 15618227136
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21-5161 9052
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Amadis Chemical Company Limited
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571-89925085
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0086-571-89925065
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Shanghai BetterBioChem Co., Ltd.
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+86-18017644823
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Twochem Co.Ltd.
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68252-19-7, PirmenolRelated Search:

Pirmenol hydrochloride 1-PHENYL-1-(2-PYRIDYL)ETHANOL 4-DIISOPROPYLAMINO-1-BUTANOL Pirmenol

  • 2-Pyridinemethanol, a-[3-(2,6-dimethyl-1-piperidinyl)propyl]-a-phenyl-, cis-
  • 2-Pyridinemethanol, a-[3-(2,6-dimethyl-1-piperidinyl)propyl]-a-phenyl-, cis-(+-)-
  • 2-Pyridinemethanol, a-[3-[(2R,6S)-2,6-dimethyl-1-piperidinyl]propyl]-a-phenyl-, rel- (9CI)
  • 2-Pyridinemethanol, α-[3-[(2R,6S)-2,6-dimethyl-1-piperidinyl]propyl]-α-phenyl-, rel-
  • Pirmenol (Cl-845)
  • rel-4-((2S,6R)-2,6-Dimethylpiperidin-1-yl)-1-phenyl-1-(pyridin-2-yl)butan-1-ol
  • Pirmenol, 10 mM in DMSO
  • (±)-Pirmenol
  • 68252-19-7