ChemicalBook > CAS DataBase List > Sulopenem

Sulopenem

Product Name: Sulopenem
CAS No.: 120788-07-0
Chemical Name: Sulopenem
Synonyms: CP-70429;Thiopenem;Sulopenem;CP-65207-S;Sulopenem USP/EP/BP;(S)-3-[[(5R)-2-Carboxy-6β-[(R)-1-hydroxyethyl]-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-en-3-yl]thio]tetrahydrothiophene 1-oxide;(5R,6S)-6-((R)-1-hydroxyethyl)-3-(((1R)-1-oxidotetrahydrothiophen-3-yl)thio)-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid;(5R,6S)-6-[(1R)-1-Hydroxyethyl]-7-oxo-3-[[(1R,3S)-tetrahydro-1-oxido-3-thienyl]thio]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid;4-Thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 6-[(1R)-1-hydroxyethyl]-7-oxo-3-[[(1R,3S)-tetrahydro-1-oxido-3-thienyl]thio]-, (5R,6S)-
CBNumber: CB81116702
Molecular Formula: C12H15NO5S3
Formula Weight: 349.45
MOL File: 120788-07-0.mol

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Sulopenem Property

Boiling point:: 693.1±55.0 °C(Predicted)
Density: 1.74±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
pka: 3.88±0.40(Predicted)
form: Solid
color: White to yellow
InChI: InChI=1S/C12H15NO5S3/c1-5(14)7-9(15)13-8(11(16)17)12(20-10(7)13)19-6-2-3-21(18)4-6/h5-7,10,14H,2-4H2,1H3,(H,16,17)/t5-,6+,7+,10-,21-/m1/s1
InChIKey: FLSUCZWOEMTFAQ-PRBGKLEPSA-N
SMILES: N12[C@@]([H])([C@@H]([C@H](O)C)C1=O)SC(S[C@H]1CC[S@@](=O)C1)=C2C(O)=O

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PZ0042
Product name: Sulopenem
Purity: ≥97% (HPLC)
Packaging: 5 mg
Price: $108
Updated: 2025/07/31

Sigma-Aldrich

Product number: PZ0042
Product name: Sulopenem
Purity: ≥97% (HPLC)
Packaging: 25 mg
Price: $436
Updated: 2025/07/31

TRC

Product number: S789485
Product name: Sulopenem
Packaging: 0.5mg
Price: $415
Updated: 2021/12/16

ChemScene

Product number: CS-0025618
Product name: Sulopenem
Purity: 98.06%
Packaging: 5mg
Price: $200
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0006068
Product name: SULOPENEM
Purity: 95.00%
Packaging: 5MG
Price: $500.13
Updated: 2021/12/16

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Sulopenem Chemical Properties,Usage,Production

Description

Sulopenem is a parenteral penem that demonstrates high activity against Gram-positive, Gram-negative, and anaerobic bacteria. Since it is stable in relation to renal dehydropeptidase I, it does not require concomitant administration of an inhibitor of this enzyme.

Uses

Antibacterial.

Uses

Sulopenem is a β-Lactamase inhibitor which is used in treatment of microbial infections. It is an important reagent for many drugs synthesized against bacterial infections.

Mechanism of action

Sulopenem is one of the penems and, as such, interacts with penicillin-binding proteins (PBPs). From in vitro studies, sulopenem has shown a high affinity for PBP1a, 1b, 2, and 3 in E. coli.

Pharmacokinetics

When 1 g of CP-65,207 [containing 46.3% of S-isomer (sulopenem) and 53.7% of R-isomer] was administered by 10-minute intravenous infusions, the peak concentration of sulopenem in serum was 36.0 mg/ ml, its half-life was 52.8 minutes, and the area under the serum concentration-versus-time curve (AUC) from 0 to 8 hours was 21.0 mg/ml per hour.

in vivo

The protective effects of Sulopenem in murine experimental systemic infections are superior to those of Imipenem/Cilastatin. In murine experimental mixed infection with Escherichia coli and Bacteroides fragilis, Sulopenem has lower ED₅₀. In guinea pigs experimental lung infection with Klebsiella pneumoniae, Sulopenem is more effective than CZON or Cefotiam^[3].

IC 50

β-lactam

Sulopenem Preparation Products And Raw materials

Raw materials

Preparation Products

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Sulopenem Suppliers

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View Lastest Price from Sulopenem manufacturers

Career Henan Chemica Co

Product: Sulopenem 120788-07-0
Price: US $0.01/KG
Min. Order: 1KG
Purity: 95%-99%
Supply Ability: 1kg; 5kg; 10kg
Release date: 2020-10-28

120788-07-0, SulopenemRelated Search:

N-(3-MERCAPTO-2-METHYLPROPANOYL)GLYCINE (AZETIDIN-3-YL)METHANOL Sulopenem Meropenem Faropenem sodium Imipenem

(S)-3-[[(5R)-2-Carboxy-6β-[(R)-1-hydroxyethyl]-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-en-3-yl]thio]tetrahydrothiophene 1-oxide

CP-65207-S

CP-70429

Sulopenem

(5R,6S)-6-[(1R)-1-Hydroxyethyl]-7-oxo-3-[[(1R,3S)-tetrahydro-1-oxido-3-thienyl]thio]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid

4-Thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 6-[(1R)-1-hydroxyethyl]-7-oxo-3-[[(1R,3S)-tetrahydro-1-oxido-3-thienyl]thio]-, (5R,6S)-

Sulopenem USP/EP/BP

(5R,6S)-6-((R)-1-hydroxyethyl)-3-(((1R)-1-oxidotetrahydrothiophen-3-yl)thio)-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid

Thiopenem

120788-07-0

C12H15NO5S3

API