Sorbinil

Product Name: Sorbinil
CAS No.: 68367-52-2
Chemical Name: Sorbinil
Synonyms: CP-45634;(S)-(+)-Sorbinil;Sorbinil >=98% (HPLC);inhibit,Aldose Reductase,Sorbinil,Inhibitor;(+)-(4S)-6-Fluorospiro[chroman-4,4′-imidazolidine]-2′,5′-dione;(4S)-6-fluorospiro[2,3-dihydrochromene-4,5'-imidazolidine]-2',4'-dione;(4S)-6-Fluorospiro[2H-1-benzopyran-4(3H),4'-imidazolidine]-2',5'-dione;(S)-6-Fluoro-2,3-dihydrospiro[4H-1-benzopyran-4,4'-imidazolidine]-2',5'-dione;(4S)-6-Fluoro-2,3-dihydrospiro[4H-1-benzopyran-4,4'-imidazolidine]-2',5'-dione;(4S)-6'-Fluoro-2',3'-dihydrospiro[imidazolidine-4,4'-[4H][1]benzopyran]-2,5-dione
CBNumber: CB81117527
Molecular Formula: C11H9FN2O3
Formula Weight: 236.2
MOL File: 68367-52-2.mol

More

Less

Sorbinil Property

Melting point:: 241-243°
alpha: D25 +54.0° (c = 1 in methanol)
Density: 1.52
storage temp.: 2-8°C
solubility: DMSO: ≥20mg/mL
form: powder
pka: 8.91±0.20(Predicted)
color: white to off-white
optical activity: [α]/D +50 to +60°, c = 1 in methanol

More

Less

Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S7701
Product name: Sorbinil
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $140
Updated: 2024/03/01

Sigma-Aldrich

Product number: S7701
Product name: Sorbinil
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $545
Updated: 2024/03/01

ChemScene

Product number: CS-0002274
Product name: Sorbinil
Purity: 98.31%
Packaging: 1mg
Price: $235
Updated: 2021/12/16

More

Less

Sorbinil Chemical Properties,Usage,Production

Uses

Enzyme inhibitor (aldose reductase).

Uses

Sorbinil has been used as an aldose reductase inhibitor in diabetic rats as a positive control group.

Definition

ChEBI: An azaspiro compound having a monofluoro-substituted chromane skeleton spiro-linked to an imidazolidinedione ring.

Biochem/physiol Actions

Sorbinil decreases the level of sorbitol in red blood cells and increases the velocity of nerve conduction. It maintains the myo-inositol content in the nerve and prevents the reduction of sodium-potassium ATPase activity. This action is beneficial in providing symptomatic relief in patients with diabetic neuropathy.

Sorbinil Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Sorbinil Suppliers

China 13 United Kingdom 2 United States 5 Global 20

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3420
Advantage: 58

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51471
Advantage: 80

Shanghai Synchem Pharma Co., ltd

Tel: 021-61984905-1 18016477331
Email: synchempharma@aliyun.com
Country: China
ProdList: 6454
Advantage: 55

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9730
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 19892
Advantage: 58

Hubei Jusheng Technology Co.,Ltd.

Tel: 18871490254
Fax: 027-59599243
Email: linda@hubeijusheng.com
Country: CHINA
ProdList: 28180
Advantage: 58

Hefei fuya biotechnology co. LTD

Tel: 18096409024
Email: sales02@foreversyn.com
Country: China
ProdList: 1938
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49390
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44941
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223
Email: psaitong@jm-bio.com
Country: China
ProdList: 29834
Advantage: 58

68367-52-2, SorbinilRelated Search:

(S)-1-(3-Fluorophenyl)ethanamine 2-ETHOXYPHENETHYLAMINE H-PHG-NH2 HCL (R)-1-(3-Fluorophenyl)ethylamine 6-FLUOROCHROMAN 3-(4-fluorophenoxy)propan-1-amine N-(2-METHOXYPHENETHYL)UREA 6-FLUORO-4-CHROMANONE HYDANTOIN 1-(3-FLUOROPHENYL)PROPYLAMINE Sorbinil FIDARESTAT (S)-(+)-NIRVANOL [3-(4-FLUOROPHENOXY)PROPYL]METHYLAMINE (RS)-N-[1-(3-FLUOROPHENYL)ETHYL]METHYLAMINE 2-(2-METHOXYPHENYL)-ACETAMIDE 3-(3-FLUOROPHENYL)-DL-BETA-ALANINOL 2H-1-Benzopyran-4-amine,3,4-dihydro-,(4S)-(9CI) 6-FLUORO-CHROMAN-4-YLAMINE HYDROCHLORIDE

Spiro[4H-1-benzopyran-4,4'-imidazolidine]-2',5'-dione, 6-fluoro-2,3-dihydro-, (4S)-

(4S)-6'-Fluoro-2',3'-dihydrospiro[imidazolidine-4,4'-[4H][1]benzopyran]-2,5-dione

(4S)-6-Fluorospiro[2H-1-benzopyran-4(3H),4'-imidazolidine]-2',5'-dione

(S)-6-Fluoro-2,3-dihydrospiro[4H-1-benzopyran-4,4'-imidazolidine]-2',5'-dione

CP-45634

(4S)-6-Fluoro-2,3-dihydrospiro[4H-1-benzopyran-4,4'-imidazolidine]-2',5'-dione

(S)-(+)-Sorbinil

(+)-(4S)-6-Fluorospiro[chroman-4,4′-imidazolidine]-2′,5′-dione

(4S)-6-fluorospiro[2,3-dihydrochromene-4,5'-imidazolidine]-2',4'-dione

Sorbinil >=98% (HPLC)

inhibit,Aldose Reductase,Sorbinil,Inhibitor

68367-52-2