Sorbinil

Product Name: Sorbinil
CAS No.: 68367-52-2
Chemical Name: Sorbinil
Synonyms: CP-45634;(S)-(+)-Sorbinil;Sorbinil >=98% (HPLC);inhibit,Aldose Reductase,Sorbinil,Inhibitor;(+)-(4S)-6-Fluorospiro[chroman-4,4′-imidazolidine]-2′,5′-dione;(4S)-6-fluorospiro[2,3-dihydrochromene-4,5'-imidazolidine]-2',4'-dione;(4S)-6-Fluorospiro[2H-1-benzopyran-4(3H),4'-imidazolidine]-2',5'-dione;(S)-6-Fluoro-2,3-dihydrospiro[4H-1-benzopyran-4,4'-imidazolidine]-2',5'-dione;(4S)-6-Fluoro-2,3-dihydrospiro[4H-1-benzopyran-4,4'-imidazolidine]-2',5'-dione;(4S)-6'-Fluoro-2',3'-dihydrospiro[imidazolidine-4,4'-[4H][1]benzopyran]-2,5-dione
CBNumber: CB81117527
Molecular Formula: C11H9FN2O3
Formula Weight: 236.2
MOL File: 68367-52-2.mol

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Sorbinil Property

Melting point:: 241-243°
alpha: D25 +54.0° (c = 1 in methanol)
Density: 1.52
storage temp.: 2-8°C
solubility: DMSO: ≥20mg/mL
form: powder
pka: 8.91±0.20(Predicted)
color: white to off-white
optical activity: [α]/D +50 to +60°, c = 1 in methanol

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S7701
Product name: Sorbinil
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $140
Updated: 2024/03/01

Sigma-Aldrich

Product number: S7701
Product name: Sorbinil
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $545
Updated: 2024/03/01

ChemScene

Product number: CS-0002274
Product name: Sorbinil
Purity: 98.31%
Packaging: 1mg
Price: $235
Updated: 2021/12/16

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Sorbinil Chemical Properties,Usage,Production

Uses

Enzyme inhibitor (aldose reductase).

Uses

Sorbinil has been used as an aldose reductase inhibitor in diabetic rats as a positive control group.

Definition

ChEBI: An azaspiro compound having a monofluoro-substituted chromane skeleton spiro-linked to an imidazolidinedione ring.

Biochem/physiol Actions

Sorbinil decreases the level of sorbitol in red blood cells and increases the velocity of nerve conduction. It maintains the myo-inositol content in the nerve and prevents the reduction of sodium-potassium ATPase activity. This action is beneficial in providing symptomatic relief in patients with diabetic neuropathy.

Sorbinil Preparation Products And Raw materials

Raw materials

Preparation Products

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Sorbinil Suppliers

China 14 United Kingdom 2 United States 5 Global 21

ShangHai Caerulum Pharma Discovery Co., Ltd.

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Sigma-Aldrich

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Shanghai Synchem Pharma Co., ltd

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Fan De(Beijing) Biotechnology Co., Ltd.

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Hubei Jusheng Technology Co.,Ltd.

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Hefei fuya biotechnology co. LTD

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CONIER CHEM AND PHARMA LIMITED

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Energy Chemical

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Beijing Jin Ming Biotechnology Co., Ltd.

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TargetMol Chemicals Inc.

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Nanjing Shizhou Biology Technology Co.,Ltd

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RD International Technology Co., Limited

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Shanghai Hao Zhun Biological Technology Co., Ltd.

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68367-52-2, SorbinilRelated Search:

(S)-1-(3-Fluorophenyl)ethanamine 2-ETHOXYPHENETHYLAMINE H-PHG-NH2 HCL (R)-1-(3-Fluorophenyl)ethylamine 6-FLUOROCHROMAN 3-(4-fluorophenoxy)propan-1-amine N-(2-METHOXYPHENETHYL)UREA 6-FLUORO-4-CHROMANONE HYDANTOIN 1-(3-FLUOROPHENYL)PROPYLAMINE Sorbinil FIDARESTAT (S)-(+)-NIRVANOL [3-(4-FLUOROPHENOXY)PROPYL]METHYLAMINE (RS)-N-[1-(3-FLUOROPHENYL)ETHYL]METHYLAMINE 2-(2-METHOXYPHENYL)-ACETAMIDE 3-(3-FLUOROPHENYL)-DL-BETA-ALANINOL 2H-1-Benzopyran-4-amine,3,4-dihydro-,(4S)-(9CI) 6-FLUORO-CHROMAN-4-YLAMINE HYDROCHLORIDE

Spiro[4H-1-benzopyran-4,4'-imidazolidine]-2',5'-dione, 6-fluoro-2,3-dihydro-, (4S)-

(4S)-6'-Fluoro-2',3'-dihydrospiro[imidazolidine-4,4'-[4H][1]benzopyran]-2,5-dione

(4S)-6-Fluorospiro[2H-1-benzopyran-4(3H),4'-imidazolidine]-2',5'-dione

(S)-6-Fluoro-2,3-dihydrospiro[4H-1-benzopyran-4,4'-imidazolidine]-2',5'-dione

CP-45634

(4S)-6-Fluoro-2,3-dihydrospiro[4H-1-benzopyran-4,4'-imidazolidine]-2',5'-dione

(S)-(+)-Sorbinil

(+)-(4S)-6-Fluorospiro[chroman-4,4′-imidazolidine]-2′,5′-dione

(4S)-6-fluorospiro[2,3-dihydrochromene-4,5'-imidazolidine]-2',4'-dione

Sorbinil >=98% (HPLC)

inhibit,Aldose Reductase,Sorbinil,Inhibitor

68367-52-2