4-(TOLUENE-4-SULFONYLOXY)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- Product Name
- 4-(TOLUENE-4-SULFONYLOXY)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- CAS No.
- 118811-07-7
- Chemical Name
- 4-(TOLUENE-4-SULFONYLOXY)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- Synonyms
- 104618;Pozitinib intermediate 7;N-BOC-4-TOXYLOXY-PIPERIDINE;1-Boc-4-(tosyloxy)piperidine;(1-BOC-piperidin-4-yl)tosylate;N-Boc-4-piperidyl p-Methylbenzenesulfonate;t-Butyl 4-(tosyloxy)piperidine-1-carboxylate;tert-butyl 4-(tosyloxy)piperidine-1-carboxylate;4-Tosyloxypiperidine-1-carboxylic Acid tert-Butyl Es;1-(tert-Butoxycarbonyl)-4-(p-toluenesulfonyloxy)piperidine
- CBNumber
- CB81118751
- Molecular Formula
- C17H25NO5S
- Formula Weight
- 355.45
- MOL File
- 118811-07-7.mol
4-(TOLUENE-4-SULFONYLOXY)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Property
- Melting point:
- 96.0 to 100.0 °C
- Boiling point:
- 475.3±38.0 °C(Predicted)
- Density
- 1.23±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- -2.97±0.40(Predicted)
- color
- White to Almost white
- InChI
- InChI=1S/C17H25NO5S/c1-13-5-7-15(8-6-13)24(20,21)23-14-9-11-18(12-10-14)16(19)22-17(2,3)4/h5-8,14H,9-12H2,1-4H3
- InChIKey
- IKOMRHLHPZAEMV-UHFFFAOYSA-N
- SMILES
- N1(C(OC(C)(C)C)=O)CCC(OS(C2=CC=C(C)C=C2)(=O)=O)CC1
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- B4516
- Product name
- 1-(tert-Butoxycarbonyl)-4-(p-toluenesulfonyloxy)piperidine
- Purity
- >98.0%(HPLC)
- Packaging
- 1g
- Price
- $38
- Updated
- 2025/07/31
- Product number
- B4516
- Product name
- 1-(tert-Butoxycarbonyl)-4-(p-toluenesulfonyloxy)piperidine
- Purity
- >98.0%(HPLC)
- Packaging
- 5g
- Price
- $132
- Updated
- 2021/12/16
- Product number
- B414223
- Product name
- 1-boc-4-(Tosyloxy)piperidine
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- Z3335
- Product name
- N-Boc-4-tosyloxypiperidine
- Packaging
- 5g
- Price
- $111
- Updated
- 2021/12/16
- Product number
- 43415
- Product name
- 1-(tert-Butoxycarbonyl)-4-(p-toluenesulfonyloxy)piperidine,≥98%(HPLC)
- Purity
- ≥98%(HPLC)
- Packaging
- 1G
- Price
- $40.45
- Updated
- 2021/12/16
4-(TOLUENE-4-SULFONYLOXY)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production
Synthesis
98-59-9
109384-19-2
118811-07-7
To a solution of N-Boc-4-hydroxypiperidine (5 g, 24.8 mmol) in dichloromethane (50 mL) was sequentially added triethylamine (13.9 mL, 99.4 mmol) and p-toluenesulfonyl chloride (9.47 g, 49.7 mmol). The reaction mixture was stirred at room temperature for 20 hours. Upon completion of the reaction, the solution was concentrated in vacuum. The residue was redissolved in a mixture of dichloromethane (20 mL) and water (20 mL) and the organic layer was extracted with dichloromethane (20 mL). Subsequently, the organic layer was washed with 1N HCl (40 mL) and extracted twice more with dichloromethane (2 x 40 mL). The organic layers were combined, dried with anhydrous magnesium sulfate, filtered and concentrated. Finally, the crude product was purified by silica gel column chromatography (petroleum ether/ethyl acetate, 8:2) to afford tert-butyl 4-(toluene-4-sulfonyloxy)piperidine-1-carboxylate (8.7 g, quantitative yield) as a white crystalline solid.
References
[1] Patent: WO2018/50771, 2018, A1. Location in patent: Page/Page column 72
[2] Patent: WO2007/102883, 2007, A2. Location in patent: Page/Page column 36-37
[3] Patent: WO2013/170072, 2013, A2. Location in patent: Paragraph 001074
[4] Patent: WO2007/30366, 2007, A1. Location in patent: Page/Page column 135
[5] Journal of Medicinal Chemistry, 2012, vol. 55, # 22, p. 9958 - 9972
4-(TOLUENE-4-SULFONYLOXY)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials
Raw materials
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View Lastest Price from 4-(TOLUENE-4-SULFONYLOXY)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER manufacturers
- Product
- 4-(TOLUENE-4-SULFONYLOXY)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 118811-07-7
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2019-05-25