1-Boc-4-methanesulfonyloxypiperidine

Product Name: 1-Boc-4-methanesulfonyloxypiperidine
CAS No.: 141699-59-4
Chemical Name: 1-Boc-4-methanesulfonyloxypiperidine
Synonyms: tert-butyl4-(Methylsulfonyloxy)piperidine-1-carboxylate;tert-butyl 4-(methanesulfonyloxy)piperidine-1-carboxylate;4-METHANESULFONYLOXY-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;Crizotinib Impurity 12;)oxy)piperidine-1-carboxyL;1-Boc-methanesulfonyl-piperdine;1-Boc-4-methanesulfonyloxy-piper;L-Valine,6-mercapto-,methylester;1-BOC-4-METHANESULFONYLOXY-PIPERIDINE;N-BOC-4-(methanesulfonyloxy)piperidine
CBNumber: CB5391495
Molecular Formula: C11H21NO5S
Formula Weight: 279.35
MOL File: 141699-59-4.mol

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1-Boc-4-methanesulfonyloxypiperidine Property

Melting point:: 193-195 °C
Boiling point:: 407.2±34.0 °C(Predicted)
Density: 1.22±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: powder to crystal
pka: -3.02±0.40(Predicted)
color: White to Almost white
InChI: InChI=1S/C11H21NO5S/c1-11(2,3)16-10(13)12-7-5-9(6-8-12)17-18(4,14)15/h9H,5-8H2,1-4H3
InChIKey: WOEQSXAIPTXOPY-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCC(OS(C)(=O)=O)CC1
CAS DataBase Reference: 141699-59-4(CAS DataBase Reference)

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Safety

Hazard Codes: T
Risk Statements: 25-20/21/22
Safety Statements: 45-24/25-23
RIDADR: 2811
HazardClass: 6.1
PackingGroup: Ⅲ
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B4353
Product name: 1-(tert-Butoxycarbonyl)-4-(methanesulfonyloxy)piperidine
Purity: >98.0%(GC)
Packaging: 5g
Price: $53
Updated: 2025/07/31

TCI Chemical

Product number: B4353
Product name: 1-(tert-Butoxycarbonyl)-4-(methanesulfonyloxy)piperidine
Purity: >98.0%(GC)
Packaging: 25g
Price: $260
Updated: 2025/07/31

TRC

Product number: M287603
Product name: 4-Methanesulfonyloxy-piperidine-1-carboxylicAcidtert-ButylEster
Packaging: 50mg
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: J91083
Product name: 4-Methanesulfonyloxy-piperidine-1-carboxylicacidtert-butylester
Packaging: 10g
Price: $60
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK479869
Product name: 1-Boc-4-methanesulfonyloxy-piperidine
Purity: 97%
Packaging: 1g
Price: $61
Updated: 2021/12/16

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1-Boc-4-methanesulfonyloxypiperidine Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

4-Methanesulfonyloxy-piperidine-1-carboxylic Acid tert-Butyl Ester is a useful research chemical used in the preparation of (aminoaryl)(benzyloxy)pyridines as potential antitumor agents.

Synthesis

124-63-0

109384-19-2

141699-59-4

N-Boc-4-hydroxypiperidine (10 g, 49.68 mmol, 1 eq.) and triethylamine (7.54 g, 74.50 mmol, 1.5 eq., 10.38 ml) were dissolved in anhydrous dichloromethane (200 ml) and cooled to 0-5 °C. Methylsulfonyl chloride (6.88 g, 60.12 mmol, 4.65 ml, 1.21 eq.) was added slowly and dropwise under stirring. The reaction mixture was stirred at 0-5 °C for 3 hours. After completion of the reaction, the mixture was diluted with dichloromethane (200 ml), transferred to a separatory funnel and washed sequentially with 2M aqueous sodium carbonate solution (200 ml) and saturated sodium chloride solution (200 ml). The organic layer was dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give 14.51 g of tert-butyl 4-((methylsulfonyl)oxy)piperidine-1-carboxylate as a white solid (yield = 100%). The product was confirmed by 1H-NMR (400 MHz, DMSO-d6) and mass spectrometry (EI): δ 4.80 (m, 1H), 3.39 (m, 2H), 3.29 (m, 2H), 2.94 (s, 3H), 1.77 (m, 2H), 1.52 (m, 2H); MS (EI): 280 (MH+).

References

[1] Patent: WO2008/42282, 2008, A2. Location in patent: Page/Page column 174-175
[2] Patent: WO2010/138490, 2010, A1. Location in patent: Page/Page column 28
[3] Patent: WO2010/138487, 2010, A1. Location in patent: Page/Page column 122
[4] Patent: US2011/152243, 2011, A1. Location in patent: Page/Page column 96
[5] Journal of Medicinal Chemistry, 2011, vol. 54, # 12, p. 4092 - 4108

1-Boc-4-methanesulfonyloxypiperidine Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Boc-4-methanesulfonyloxypiperidine Suppliers

Americas 1 China 187 Europe 1 France 1 Germany 6 India 2 Japan 1 The Netherlands 1 United Kingdom 11 United States 31 Global 242

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View Lastest Price from 1-Boc-4-methanesulfonyloxypiperidine manufacturers

Henan Fengda Chemical Co., Ltd

Product: tert-Butyl 4-((methylsulfonyl)oxy)piperidine-1-carboxylate 141699-59-4
Price: US $200.00-1.00/KG
Min. Order: 1KG
Purity: 99%, 99.5% Sublimated
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-30

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1-Boc-4-methanesulfonyloxypiperidine 141699-59-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Career Henan Chemical Co

Product: 1-Boc-4-methanesulfonyloxypiperidine 141699-59-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2018-08-08

141699-59-4, 1-Boc-4-methanesulfonyloxypiperidineRelated Search:

Cyhalofop-butyl tert-Butyl peroxybenzoate Tris(trimethylsilyl)phosphate DIETHOXYMETHANE tert-Butanol Butyl benzoate Haloperidol Trifluoromethanesulfonimide Butyl acetate tert-Butyl acetate 3,4,5-Trimethoxy benzoic acid tert-Butyl peroxyacetate Diisobutyl phthalate 4-Methoxybenzoic acid Buprofezin Isobutyl chloroformate Dimethoxymethane BUTYL OLEATE

N-(TERT-BUTOXYCARBONYL)PIPERIDIN-4-YL MESYLATE

1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate

1-Boc-methanesulfonyl-piperdine

4-[(Methylsulphonyl)oxy]piperidine, N-BOC protected

tert-Butyl 4-[(methylsulphonyl)oxy]piperidine-1-carboxylate

1-Piperidinecarboxylicacid,4-[(Methylsulfonyl)oxy]-,1,1-diMethylethylester

4-Methanesulfonyloxypiperidin-1-carboxylic acid tert-butyl ester

N-BOC-4-(methanesulfonyloxy)piperidine

4-Methanesulfonylo×y-piperidine-1-carbo×ylic acid tert-butyl ester

1-(tert-Butoxycarbonyl)-4-(methanesulfonyloxy)piperidine

tert-butyl4-(Methylsulfonyloxy)piperidine-1-carboxylate

t-Butyl 4-(Methanesulfonyloxy)piperidine-1-carboxylate

1-tert-butyl 3-ethyl 5-fluoropiperidine-1,3-dicarboxylate

(1-Boc-4-Methanesulfonyloxy-piperidine-carboxylate

4-METHANESULFONYLOXY-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

1-BOC-4-METHANESULFONYLOXY-PIPERIDINE

tert-butyl 4-(methanesulfonyloxy)piperidine-1-carboxylate

Crizotinib Impurity 12

tert-Butyl 4-[(methylsulphonyl)oxy]piperidine-1-carboxylate 98%

1-(tert-Butoxycarbonyl)-4-(methanesulfonyloxy)piperidine &gt

tert-Butyl 4-((methylsulfonyl)oxy)piperidine-1-carboxylate,≥98%

)oxy)piperidine-1-carboxyL

1-(tert-Butoxycarbonyl)-4-piperidyl Methanesulfonate

1-Boc-4-methanesulfonyloxy-piper

4-[(Methylsulfonyl)oxy]piperidine-1-carboxylic acid tert-butyl ester

L-Valine,6-mercapto-,methylester

<i>tert</i>-Butyl 4-((methylsulfonyl)oxy)piperidine-1-carboxylate

tert-Butyl 4-((methylsulfonyloxy))piperidin-1-carboxylate

141699-59-4

pharmacetical