3-Chloro-1,2-propanediol
Description Sources- Product Name
- 3-Chloro-1,2-propanediol
- CAS No.
- 96-24-2
- Chemical Name
- 3-Chloro-1,2-propanediol
- Synonyms
- 3-MCPD;CG;3-Chloropropane-1,2-diol;MCPD;3-Chloro-1,2-dihydroxypropane;monochlorohydrin;GAM;1-CHLORO-2,3-PROPANEDIOL;1,2-Propanediol, 3-chloro-;ALPHA-MONOCHLOROHYDRIN
- CBNumber
- CB8114778
- Molecular Formula
- C3H7ClO2
- Formula Weight
- 110.54
- MOL File
- 96-24-2.mol
3-Chloro-1,2-propanediol Property
- Melting point:
- -40°C
- Boiling point:
- 213 °C(lit.)
- Density
- 1.322 g/mL at 25 °C(lit.)
- vapor pressure
- 0.04 mm Hg ( 25 °C)
- refractive index
- n20/D 1.480(lit.)
- Flash point:
- >230 °F
- storage temp.
- 2-8°C
- solubility
- H2O: soluble
- form
- Liquid
- pka
- 13.28±0.20(Predicted)
- color
- Clear pale yellow
- Water Solubility
- Soluble
- FreezingPoint
- -40℃
- Merck
- 14,2145
- BRN
- 635684
- LogP
- 0.5 at 25℃
- CAS DataBase Reference
- 96-24-2(CAS DataBase Reference)
- IARC
- 2B (Vol. 101) 2013
- NIST Chemistry Reference
- 1,2-Propanediol, 3-chloro-(96-24-2)
- EPA Substance Registry System
- 3-Chloro-1,2-propanediol (96-24-2)
Safety
- Hazard Codes
- T
- Risk Statements
- 60-21-23/25-41-39-36-23/24/25-40
- Safety Statements
- 53-26-36-39-45-38-36/37/39-28A-36/37
- RIDADR
- UN 2689 6.1/PG 3
- WGK Germany
- 3
- RTECS
- TY4025000
- F
- 3
- TSCA
- Yes
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29055998
- Hazardous Substances Data
- 96-24-2(Hazardous Substances Data)
- Toxicity
- LD50 in mice, rats (g/kg): 0.16, 0.15 orally (Hine)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H300Fatal if swallowed
H318Causes serious eye damage
H341Suspected of causing genetic defects
H351Suspected of causing cancer
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 107271
- Product name
- (±)-3-Chloro-1,2-propanediol
- Purity
- 98%
- Packaging
- 25ml
- Price
- $53.9
- Updated
- 2024/03/01
- Product number
- 107271
- Product name
- (±)-3-Chloro-1,2-propanediol
- Purity
- 98%
- Packaging
- 500ml
- Price
- $78
- Updated
- 2024/03/01
- Product number
- C0268
- Product name
- 3-Chloro-1,2-propanediol
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $18
- Updated
- 2024/03/01
- Product number
- C0268
- Product name
- 3-Chloro-1,2-propanediol
- Purity
- >98.0%(GC)
- Packaging
- 500g
- Price
- $34
- Updated
- 2024/03/01
- Product number
- A16143
- Product name
- (±)-3-Chloro-1,2-propanediol, 98%
- Packaging
- 500g
- Price
- $32.65
- Updated
- 2024/03/01
3-Chloro-1,2-propanediol Chemical Properties,Usage,Production
Description
3-Chloro-1, 2-propanediol is unusually formed upon the thermal processing of fat-containing foods1. It is useful in organic synthesis. It is an intermediate for the drug dyphylline; used as a solvent for acetate, etc., and as an intermediate for plasticizers, surfactants, and dyes2; be used as a solvent for preparing a plasticizer, a surfactant, a dye intermediate, a drug, or as a dye intermediate mainly for use as an acetyl fiber or the like. Also used as a plasticizer, surfactant and dye intermediate. In the pharmaceutical industry, it is used in the production of phlegm and phlegm and phlegm-removing guaiac oil ether, antiasthmatic drug theophylline, and hydroxyphylline. It is warned that it is a potential carcinogen and has antifertility activity1,3.
Sources
- https://en.wikipedia.org/wiki/3-MCPD
- https://www.sigmaaldrich.com/catalog/product/aldrich/107271?lang=en®ion=US
- Gunn, S. A., T. C. Gould, and W. A. Anderson. "Possible mechanism of posttesticular antifertility action of 3-chloro-1, 2-propanediol. " Proceedings of the Society for Experimental Biology & Medicine Society for Experimental Biology & Medicine 132.2(1969): 656.
Chemical Properties
Clear pale yellow liquid
Uses
A metabolite of Dichloropropanols
Uses
It is used in the synthesis of glycerol esters,amines, and other derivatives; to lower thefreezing point of dynamite; and as a rodentchemosterilant (Merck 1989).
Uses
(±)-3-Chloro-1,2-propanediol may be used as a reference standard for the determination of (±)-3-chloro-1,2-propanediol in food samples by gas chromatography with mass spectrometric detection (GC-MS).
Uses
To lower the freezing point of dynamite; in the manufacture of dye intermediates. As rodent chemosterilant.
Definition
ChEBI: A chloropropane-1,2-diol that is propane-1,2-diol substituted by a chloro group at position 3.
Synthesis Reference(s)
Organic Syntheses, Coll. Vol. 1, p. 294, 1941
Synthetic Communications, 24, p. 1959, 1994 DOI: 10.1080/00397919408010203
Synthesis, p. 295, 1989
General Description
A colorless liquid. Denser than water. Contact may irritate skin, eyes and mucous membranes. May be toxic by ingestion. Used to make other chemicals.
Air & Water Reactions
Soluble in water. Hygroscopic.
Reactivity Profile
3-Chloro-1,2-propanediol is hygroscopic and may be sensitive to prolonged exposure to air. Glycols and their ethers undergo violent decomposition in contact with approximately 70% perchloric acid. .
Hazard
Toxic by ingestion, inhalation.
Health Hazard
Glycerol α-monochlorohydrin is a highlytoxic, teratogenic, and carcinogenic com pound. It is also an eye irritant.
Inhalation of 125 ppm in 4 hours wasfatal to rats. The lethal dose on mice viaintraperitoneal route was 10 mg/kg. Lowdosage can cause sleepiness, and on chronicexposure, weight loss
LD50 value, oral (rats): 26 mg/k
This compound is a strong teratomer,causing severe reproductive effects. Animal studies indicated that the adverse effects wereof spermatogenesis type, related to the testes,sperm duct, and Cowper’s gland. These werepaternal effects
Studies on rats indicated that high exposure levels to glycerol chlorohydrin can giverise to thyroid tumors.
Health Hazard
TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
Fire Hazard
Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.
Flammability and Explosibility
Non flammable
Safety Profile
Poison by ingestion and intraperitoneal routes. Moderately toxic by inhalation. Experimental reproductive effects. A severe eye irritant. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. A chemosterilant for rodents. Combustible when exposed to heat or flame. Reaction with perchloric acid forms a sensitive explosive product more powerful than glyceryl nitrate. When heated to decomposition it emits toxic fumes of Cl-.
Waste Disposal
Chemical incineration is the most appropriatemethod of disposal.
3-Chloro-1,2-propanediol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Chloro-1,2-propanediol manufacturers
- Product
- 3-Chloro-1,2-propanediol 96-24-2
- Price
- US $0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 2000mt/year
- Release date
- 2021-07-16
- Product
- 3-Chloro-1,2-propanediol 96-24-2
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2023-02-03
- Product
- 3-Chloro-1,2-propanediol 96-24-2
- Price
- US $8.90/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2021-11-09