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ChemicalBook > CAS DataBase List > 3-Chloro-1,2-propanediol

3-Chloro-1,2-propanediol

Description Sources
Product Name
3-Chloro-1,2-propanediol
CAS No.
96-24-2
Chemical Name
3-Chloro-1,2-propanediol
Synonyms
3-MCPD;CG;3-Chloropropane-1,2-diol;MCPD;3-Chloro-1,2-dihydroxypropane;monochlorohydrin;GAM;1-CHLORO-2,3-PROPANEDIOL;1,2-Propanediol, 3-chloro-;ALPHA-MONOCHLOROHYDRIN
CBNumber
CB8114778
Molecular Formula
C3H7ClO2
Formula Weight
110.54
MOL File
96-24-2.mol
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3-Chloro-1,2-propanediol Property

Melting point:
-40°C
Boiling point:
213 °C(lit.)
Density 
1.322 g/mL at 25 °C(lit.)
vapor pressure 
0.04 mm Hg ( 25 °C)
refractive index 
n20/D 1.480(lit.)
Flash point:
>230 °F
storage temp. 
2-8°C
solubility 
H2O: soluble
form 
Liquid
pka
13.28±0.20(Predicted)
color 
Clear pale yellow
Water Solubility 
Soluble
FreezingPoint 
-40℃
Merck 
14,2145
BRN 
635684
LogP
0.5 at 25℃
CAS DataBase Reference
96-24-2(CAS DataBase Reference)
IARC
2B (Vol. 101) 2013
NIST Chemistry Reference
1,2-Propanediol, 3-chloro-(96-24-2)
EPA Substance Registry System
3-Chloro-1,2-propanediol (96-24-2)
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Safety

Hazard Codes 
T
Risk Statements 
60-21-23/25-41-39-36-23/24/25-40
Safety Statements 
53-26-36-39-45-38-36/37/39-28A-36/37
RIDADR 
UN 2689 6.1/PG 3
WGK Germany 
3
RTECS 
TY4025000
F 
3
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
III
HS Code 
29055998
Hazardous Substances Data
96-24-2(Hazardous Substances Data)
Toxicity
LD50 in mice, rats (g/kg): 0.16, 0.15 orally (Hine)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

H318Causes serious eye damage

H341Suspected of causing genetic defects

H351Suspected of causing cancer

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
107271
Product name
(±)-3-Chloro-1,2-propanediol
Purity
98%
Packaging
25ml
Price
$53.9
Updated
2024/03/01
Sigma-Aldrich
Product number
107271
Product name
(±)-3-Chloro-1,2-propanediol
Purity
98%
Packaging
500ml
Price
$78
Updated
2024/03/01
TCI Chemical
Product number
C0268
Product name
3-Chloro-1,2-propanediol
Purity
>98.0%(GC)
Packaging
25g
Price
$18
Updated
2024/03/01
TCI Chemical
Product number
C0268
Product name
3-Chloro-1,2-propanediol
Purity
>98.0%(GC)
Packaging
500g
Price
$34
Updated
2024/03/01
Alfa Aesar
Product number
A16143
Product name
(±)-3-Chloro-1,2-propanediol, 98%
Packaging
500g
Price
$32.65
Updated
2024/03/01
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3-Chloro-1,2-propanediol Chemical Properties,Usage,Production

Description

3-Chloro-1, 2-propanediol is unusually formed upon the thermal processing of fat-containing foods1. It is useful in organic synthesis. It is an intermediate for the drug dyphylline; used as a solvent for acetate, etc., and as an intermediate for plasticizers, surfactants, and dyes2; be used as a solvent for preparing a plasticizer, a surfactant, a dye intermediate, a drug, or as a dye intermediate mainly for use as an acetyl fiber or the like. Also used as a plasticizer, surfactant and dye intermediate. In the pharmaceutical industry, it is used in the production of phlegm and phlegm and phlegm-removing guaiac oil ether, antiasthmatic drug theophylline, and hydroxyphylline. It is warned that it is a potential carcinogen and has antifertility activity1,3.

Sources

  1. https://en.wikipedia.org/wiki/3-MCPD
  2. https://www.sigmaaldrich.com/catalog/product/aldrich/107271?lang=en&region=US
  3. Gunn, S. A., T. C. Gould, and W. A. Anderson. "Possible mechanism of posttesticular antifertility action of 3-chloro-1, 2-propanediol. " Proceedings of the Society for Experimental Biology & Medicine Society for Experimental Biology & Medicine 132.2(1969): 656.

Chemical Properties

Clear pale yellow liquid

Uses

A metabolite of Dichloropropanols

Uses

It is used in the synthesis of glycerol esters,amines, and other derivatives; to lower thefreezing point of dynamite; and as a rodentchemosterilant (Merck 1989).

Uses

(±)-3-Chloro-1,2-propanediol may be used as a reference standard for the determination of (±)-3-chloro-1,2-propanediol in food samples by gas chromatography with mass spectrometric detection (GC-MS).

Uses

To lower the freezing point of dynamite; in the manufacture of dye intermediates. As rodent chemosterilant.

Definition

ChEBI: A chloropropane-1,2-diol that is propane-1,2-diol substituted by a chloro group at position 3.

Synthesis Reference(s)

Organic Syntheses, Coll. Vol. 1, p. 294, 1941
Synthetic Communications, 24, p. 1959, 1994 DOI: 10.1080/00397919408010203
Synthesis, p. 295, 1989

General Description

A colorless liquid. Denser than water. Contact may irritate skin, eyes and mucous membranes. May be toxic by ingestion. Used to make other chemicals.

Air & Water Reactions

Soluble in water. Hygroscopic.

Reactivity Profile

3-Chloro-1,2-propanediol is hygroscopic and may be sensitive to prolonged exposure to air. Glycols and their ethers undergo violent decomposition in contact with approximately 70% perchloric acid. .

Hazard

Toxic by ingestion, inhalation.

Health Hazard

Glycerol α-monochlorohydrin is a highlytoxic, teratogenic, and carcinogenic com pound. It is also an eye irritant.
Inhalation of 125 ppm in 4 hours wasfatal to rats. The lethal dose on mice viaintraperitoneal route was 10 mg/kg. Lowdosage can cause sleepiness, and on chronicexposure, weight loss
LD50 value, oral (rats): 26 mg/k
This compound is a strong teratomer,causing severe reproductive effects. Animal studies indicated that the adverse effects wereof spermatogenesis type, related to the testes,sperm duct, and Cowper’s gland. These werepaternal effects
Studies on rats indicated that high exposure levels to glycerol chlorohydrin can giverise to thyroid tumors.

Health Hazard

TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.

Flammability and Explosibility

Non flammable

Biological Activity

3-Chloro-1,2-propanediol is a potent rodent chemosterilant.

Safety Profile

Poison by ingestion and intraperitoneal routes. Moderately toxic by inhalation. Experimental reproductive effects. A severe eye irritant. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. A chemosterilant for rodents. Combustible when exposed to heat or flame. Reaction with perchloric acid forms a sensitive explosive product more powerful than glyceryl nitrate. When heated to decomposition it emits toxic fumes of Cl-.

Waste Disposal

Chemical incineration is the most appropriatemethod of disposal.

3-Chloro-1,2-propanediol Preparation Products And Raw materials

Raw materials

dilute sulphuric acid Epichlorohydrin Propylene glycol

Preparation Products

3-Phenoxy-1,2-propanediol Guaifenesin 3-Amino-1,2-propanediol Doxofylline Dropropizine
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View Lastest Price from 3-Chloro-1,2-propanediol manufacturers

Jinan Finer Chemical Co., Ltd
Product
3-Chloro-1,2-propanediol 96-24-2
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
99%
Supply Ability
2000mt/year
Release date
2021-07-16
Hebei Weibang Biotechnology Co., Ltd
Product
3-Chloro-1,2-propanediol 96-24-2
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-12-02
Hong Kong Tiansheng New Material Trading Co., Ltd
Product
3-Chloro-1,2-propanediol 96-24-2
Price
US $8.90/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2021-11-09

96-24-2, 3-Chloro-1,2-propanediolRelated Search:

2-METHYL-1,3-PROPANEDIOL 1-Methoxy-2-propyl acetate Propylene glycol Epichlorohydrin Poly(propylene glycol) Glycerol 1-Methoxy-2-propanol 1-Phenoxy-2-propanol Diethylstilbestrol N-Despropyl Propafenone Hydrochloride FLAVANONE 4'-Hydroxy propafenone HCl 2'-Hydroxy-3-phenylpropiophenone (R)-Propafenone Propafenone IMpurity H (EP/BP/USP) N-Depropyl N-Benzyl Propafenone (S)-Propafenone Propafenone Impurity 23 (Propafenone β-D-Glucuronide)

  • ,’-Dihydroxy-iso-propylchloride
  • 1,2-Dihydroxy-3-chloropropane
  • 1,2-Propanediol, 3-dichloro-
  • 1-Chloro-1-deoxyglycerol
  • 1-Chloropropane-2,3-diol
  • 2-Propanediol,3-chloro-1
  • 3-Chloro-1,2-dihydroxypropane
  • beta,beta’-dihydroxyisopropylchloride
  • beta,beta'-Dihydroxyisopropyl chloride
  • Chlorodeoxyglycerol
  • -Chlorohydrin
  • Epibloc
  • Glycerin alpha-monochlorhydrin
  • Glycerin epichlorohydrin
  • glycerinalpha-monochlorhydrin
  • glycerinepichlorohydrin
  • Glycerol 3-chlorohydrin
  • glycerol3-chlorohydrin
  • Glyceryl alpha-chlorohydrin
  • Glyceryl chloride
  • glyceryl-alpha-chlorohydrin
  • MONOCHLORHYDRIN
  • GLYCERYL-A-CHLOROHYDRIN
  • GLYCEROL ALPHA-MONOCHLOROHYDRIN
  • GLYCEROL ALPHA-CHLOROHYDRIN
  • glycerol-alpha-chlorohydrine
  • GLYCERIN-ALPHA-CHLOROHYDRIN
  • GLYCERINE-ALPHA-MONOCHLOROHYDRIN
  • GAM
  • CG
  • CHLOROPROPANEDIOL
  • Chlorhydrin
  • 3-chloro-1,2-hydroxypropane
  • α-Chlorohydrin, α-Glycerol chlorohydrin, α-Monochlorohydrin
  • GLYCERIN-ALPHA-MONOCHLOROHYDRIN
  • 3-Chloro-1,2-propanediolGlycerol-alpha-chlorohydrine
  • 3-Chloro-1,2-propanediol in ethyl acetate
  • (±)-3-Chloro-1,2-propanediol,α-Chlorohydrin, α-Glycerol chlorohydrin, α-Monochlorohydrin, 3-MCPD
  • 3-chloro-glycerol
  • Chloro-1,2-propan
  • (+/-)-2,3-Dihydroxy- chloropropane
  • (RS)-α-Chlorohydrin
  • alpha-Chlorohydrin Glycerol alpha-Monochlorohydrin alpha-Monochlorohydrin
  • 3-Chloro-1,2-propanediol solution
  • 3-CHLORO-1,2-PROPANEDIOL FOR SYNTHESIS
  • α-Chloroglycerin
  • 3-Chloro-1,2-propandiol
  • 3-Chloro-1,2-propylene glycol
  • 3-chloro-1,2-propyleneglycol
  • 3-chloro-2-propanediol
  • 3-Chloropropandiol-(1,2)
  • 3-chloro-propane-1,2-diol
  • 3-Chloropropane-1,2-diol
  • 3-Chloropropanediol
  • alpha-chlorhydrin
  • alpha-Monochlorohydrine
  • glycerylalpha-chlorohydrin
  • glycerylchloride