Azumolene Sodium Salt
- Product Name
- Azumolene Sodium Salt
- CAS No.
- 105336-14-9
- Chemical Name
- Azumolene Sodium Salt
- Synonyms
- EU 4093;Azumolene Sodium Salt;Azumolene sodium anhydrous;AzumolenesodiumanhydrousAzumolenesodiumanhydrous;1-[[[5-(4-Bromophenyl)-2-oxazolyl]methylene]amino]-2,4-imidazolidinedione Sodium Sal;1-[[[5-(4-Bromophenyl)-2-oxazolyl]methylene]amino]-2,4-imidazolidinedione Sodium Salt
- CBNumber
- CB81176139
- Molecular Formula
- C13H10BrN4NaO3
- Formula Weight
- 373.14
- MOL File
- 105336-14-9.mol
Azumolene Sodium Salt Property
- Melting point:
- >240°C (dec.)
- storage temp.
- Hygroscopic, Refrigerator, Under Inert Atmosphere
- solubility
- Acetonitrile (Slightly), DMSO (Slightly), Water (Slightly)
- form
- Solid
- color
- Off-White to Pale Yellow
N-Bromosuccinimide Price
- Product number
- 16462
- Product name
- Azumolene (sodium salt)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 16462
- Product name
- Azumolene (sodium salt)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $161
- Updated
- 2024/03/01
- Product number
- 16462
- Product name
- Azumolene (sodium salt)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $283
- Updated
- 2024/03/01
- Product number
- A965300
- Product name
- AzumoleneSodiumSalt
- Packaging
- 10mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- A965300
- Product name
- AzumoleneSodiumSalt
- Packaging
- 1mg
- Price
- $50
- Updated
- 2021/12/16
Azumolene Sodium Salt Chemical Properties,Usage,Production
Description
Azumolene is a muscle relaxant that inhibits the release of calcium from skeletal muscle sarcoplasmic reticulum. It inhibits a component of store-operated calcium entry (SOCE) that is coupled to the skeletal muscle ryanodine receptor, with 20 μM azumolene causing a 70% reduction in SOCE in myotubes. Azumolene has utility in countering muscle dysfunction associated with malignant hyperthermia.
Chemical Properties
Off-White to Pale Yellow Solid
Uses
Skeletal muscle relaxant
Definition
ChEBI: Azumolene sodium is the anhydrous sodium salt of azumolene. It contains an azumolene(1-).
References
[1] S S PALNITKAR. Pharmacological distinction between dantrolene and ryanodine binding sites: evidence from normal and malignant hyperthermia-susceptible porcine skeletal muscle.[J]. Biochemical Journal, 1997, 326 ( Pt 3): 847-852. DOI: 10.1042/bj3260847
[2] G.C. LESLIE N. J P. The effect of EU4093 (azumolene sodium) on the contraction of intrafusal muscle in the soleus muscle of the anaesthetized rat[J]. British Journal of Pharmacology, 1989, 97 4: 1151-1156. DOI: 10.1111/j.1476-5381.1989.tb12573.x
[3] XIAOLI ZHAO. Azumolene inhibits a component of store-operated calcium entry coupled to the skeletal muscle ryanodine receptor.[J]. The Journal of Biological Chemistry, 2006, 281 44: 33477-33486. DOI: 10.1074/jbc.m602306200
[4] VIKTOR YAROTSKYY R T D Feliciano Protasi. Accelerated activation of SOCE current in myotubes from two mouse models of anesthetic- and heat-induced sudden death.[J]. PLoS ONE, 2013: e77633. DOI: 10.1371/journal.pone.0077633
Azumolene Sodium Salt Preparation Products And Raw materials
Raw materials
Preparation Products
Azumolene Sodium Salt Suppliers
- Tel
- --
- Fax
- --
- sales@carbosynth.com
- Country
- United Kingdom
- ProdList
- 6005
- Advantage
- 58