Succinimidyl 6-[3-(2-Pyridyldithio)propionamido]hexanoate

Product Name: Succinimidyl 6-[3-(2-Pyridyldithio)propionamido]hexanoate
CAS No.: 158913-22-5
Chemical Name: Succinimidyl 6-[3-(2-Pyridyldithio)propionamido]hexanoate
Synonyms: SPDP-C6-NHS ester;N-succinimidyl 6-(3-(2-pyridyldithio)propionamido)hexanoate;2,5-dioxopyrrolidin-1-yl 6-(3-(pyridin-2-yldisulfaneyl)propanamido)hexanoate;(2,5-dioxopyrrolidin-1-yl) 6-[3-(2-pyridyldisulfanyl)propanoylamino]hexanoate;N-[6-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-6-oxohexyl]-3-(2-pyridinyldithio)propanaMide;Hexanoic acid, 6-[[1-oxo-3-(2-pyridinyldithio)propyl]amino]-, 2,5-dioxo-1-pyrrolidinyl ester
CBNumber: CB81176795
Molecular Formula: C18H23N3O5S2
Formula Weight: 425.52
MOL File: 158913-22-5.mol

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Succinimidyl 6-[3-(2-Pyridyldithio)propionamido]hexanoate Property

Melting point:: 82-84°C
Density: 1.36±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: 100 mg/mL (235.01 mM)
form: Solid
pka: 15.67±0.46(Predicted)
color: White

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Safety

HS Code: 2928009090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 803642
Product name: LC-SPDP (succinimidyl 6-[3(2-pyridyldithio)propionamido]hexanoate)
Packaging: 50MG
Price: $444
Updated: 2024/03/01

TRC

Product number: S691800
Product name: Succinimidyl6-[3-(2-Pyridyldithio)propionamido]hexanoate
Packaging: 10mg
Price: $170
Updated: 2021/12/16

AK Scientific

Product number: 7726AH
Product name: Succinimidyl6-[3-(2-pyridyldithio)propionamido]hexanoate
Packaging: 50mg
Price: $293
Updated: 2021/12/16

BroadPharm

Product number: BP-22651
Product name: SPDP-C6-NHSester
Purity: 90%
Packaging: 100mg
Price: $380
Updated: 2021/12/16

AK Scientific

Product number: 7726AH
Product name: Succinimidyl6-[3-(2-pyridyldithio)propionamido]hexanoate
Packaging: 100mg
Price: $428
Updated: 2021/12/16

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Succinimidyl 6-[3-(2-Pyridyldithio)propionamido]hexanoate Chemical Properties,Usage,Production

Description

SPDP-C6-NHS ester contains a disulfide bond which is cleavable upon reduction. The NHS ester is reactive toward primary amine and sulfhydryl groups. SPDP-C6-NHS ester is commonly used for bioconjugation and reversible crosslinkings.

Chemical Properties

White Solid

Uses

A sulfhydryl and amino reactive heterobifunctional protein crosslinking reagent.

General Description

The amine-reactive portion of SPDP reagents is the N-hydroxysuccinimide (NHS) ester. Reactions are most commonly performed in phosphate, carbonate/bicarbonate, or borate buffers at pH 7-8. Other buffers can be used provided they do not contain primary amines (or thiols or disulfide reducing reagents – see discussion of the sulfhydryl reactivity). The rate of reaction and degradation by hydrolysis increases with increasing pH; for example, the half-life of the NHS ester is several hours at pH 7 and less than 10 minutes at pH 9. NHS-ester reagents like SPDP and LC-SPDP have limited aqueous solubility and must be dissolved in organic solvent before adding them to a reaction mixture. Sulfo-NHS-ester reagents like Sulfo-LC-SPDP are water-soluble and can be added directly to aqueous reaction mixtures.

Succinimidyl 6-[3-(2-Pyridyldithio)propionamido]hexanoate Preparation Products And Raw materials

Raw materials

Preparation Products

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Succinimidyl 6-[3-(2-Pyridyldithio)propionamido]hexanoate Suppliers

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View Lastest Price from Succinimidyl 6-[3-(2-Pyridyldithio)propionamido]hexanoate manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: SPDP-C6-NHS ester 158913-22-5
Price: US $0.00/mg
Min. Order: 50mg
Purity: >99.00%
Supply Ability: 50mg
Release date: 2024-03-21

158913-22-5, Succinimidyl 6-[3-(2-Pyridyldithio)propionamido]hexanoateRelated Search:

N-SUCCINIMIDYL 6-(3-MALEIMIDOPROPIONAMIDO) HEXANOATE 6-Acetamidohexanoic acid Succinimidyl 6-[3-(2-Pyridyldithio)propionamido]hexanoate Sulfo-N-succinimidyl 6-[3-(2-Pyridyldithio)propionamido] Hexanoate, Sodium Salt

N-succinimidyl 6-(3-(2-pyridyldithio)propionamido)hexanoate

N-[6-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-6-oxohexyl]-3-(2-pyridinyldithio)propanaMide

SPDP-C6-NHS ester

Hexanoic acid, 6-[[1-oxo-3-(2-pyridinyldithio)propyl]amino]-, 2,5-dioxo-1-pyrrolidinyl ester

2,5-dioxopyrrolidin-1-yl 6-(3-(pyridin-2-yldisulfaneyl)propanamido)hexanoate

(2,5-dioxopyrrolidin-1-yl) 6-[3-(2-pyridyldisulfanyl)propanoylamino]hexanoate

158913-22-5

MTS and Sulfhydryl Active Reagents

MTS & Sulfhydryl Active Reagents