Succinimidyl 6-[3-(2-Pyridyldithio)propionamido]hexanoate
- Product Name
- Succinimidyl 6-[3-(2-Pyridyldithio)propionamido]hexanoate
- CAS No.
- 158913-22-5
- Chemical Name
- Succinimidyl 6-[3-(2-Pyridyldithio)propionamido]hexanoate
- Synonyms
- SPDP-C6-NHS;SPDP-C6-NHS ester;N-succinimidyl 6-(3-(2-pyridyldithio)propionamido)hexanoate;2,5-dioxopyrrolidin-1-yl 6-(3-(pyridin-2-yldisulfaneyl)propanamido)hexanoate;(2,5-dioxopyrrolidin-1-yl) 6-[3-(2-pyridyldisulfanyl)propanoylamino]hexanoate;(2,5-dioxopyrrolidin-1-yl) 6-[3-(pyridin-2-yldisulfanyl)propanoylamino]hexanoate;N-[6-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-6-oxohexyl]-3-(2-pyridinyldithio)propanaMide;Hexanoic acid, 6-[[1-oxo-3-(2-pyridinyldithio)propyl]amino]-, 2,5-dioxo-1-pyrrolidinyl ester
- CBNumber
- CB81176795
- Molecular Formula
- C18H23N3O5S2
- Formula Weight
- 425.52
- MOL File
- 158913-22-5.mol
Succinimidyl 6-[3-(2-Pyridyldithio)propionamido]hexanoate Property
- Melting point:
- 82-84°C
- Density
- 1.36±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: 100 mg/mL (235.01 mM)
- form
- Solid
- pka
- 15.67±0.46(Predicted)
- color
- White
- InChI
- 1S/C18H23N3O5S2/c22-14(10-13-27-28-15-6-3-5-12-20-15)19-11-4-1-2-7-18(25)26-21-16(23)8-9-17(21)24/h3,5-6,12H,1-2,4,7-11,13H2,(H,19,22)
- InChIKey
- QYEAAMBIUQLHFQ-UHFFFAOYSA-N
- SMILES
- O=C1CCC(N1OC(CCCCCNC(CCSSC2=CC=CC=N2)=O)=O)=O
Safety
- WGK Germany
- WGK 3
- HS Code
- 2928009090
- Storage Class
- 11 - Combustible Solids
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- 803642
- Product name
- LC-SPDP (succinimidyl 6-[3(2-pyridyldithio)propionamido]hexanoate)
- Packaging
- 50MG
- Price
- $812
- Updated
- 2026/03/19
- Product number
- S691800
- Product name
- Succinimidyl6-[3-(2-Pyridyldithio)propionamido]hexanoate
- Packaging
- 10mg
- Price
- $170
- Updated
- 2021/12/16
- Product number
- 7726AH
- Product name
- Succinimidyl6-[3-(2-pyridyldithio)propionamido]hexanoate
- Packaging
- 50mg
- Price
- $293
- Updated
- 2021/12/16
- Product number
- BP-22651
- Product name
- SPDP-C6-NHSester
- Purity
- 90%
- Packaging
- 100mg
- Price
- $380
- Updated
- 2021/12/16
- Product number
- 7726AH
- Product name
- Succinimidyl6-[3-(2-pyridyldithio)propionamido]hexanoate
- Packaging
- 100mg
- Price
- $428
- Updated
- 2021/12/16
Succinimidyl 6-[3-(2-Pyridyldithio)propionamido]hexanoate Chemical Properties,Usage,Production
Description
SPDP-C6-NHS ester contains a disulfide bond which is cleavable upon reduction. The NHS ester is reactive toward primary amine and sulfhydryl groups. SPDP-C6-NHS ester is commonly used for bioconjugation and reversible crosslinkings.
Chemical Properties
White Solid
Uses
A sulfhydryl and amino reactive heterobifunctional protein crosslinking reagent.
General Description
The amine-reactive portion of SPDP reagents is the N-hydroxysuccinimide (NHS) ester. Reactions are most commonly performed in phosphate, carbonate/bicarbonate, or borate buffers at pH 7-8. Other buffers can be used provided they do not contain primary amines (or thiols or disulfide reducing reagents – see discussion of the sulfhydryl reactivity). The rate of reaction and degradation by hydrolysis increases with increasing pH; for example, the half-life of the NHS ester is several hours at pH 7 and less than 10 minutes at pH 9. NHS-ester reagents like SPDP and LC-SPDP have limited aqueous solubility and must be dissolved in organic solvent before adding them to a reaction mixture. Sulfo-NHS-ester reagents like Sulfo-LC-SPDP are water-soluble and can be added directly to aqueous reaction mixtures.
reaction suitability
reagent type: cross-linking reagent
Succinimidyl 6-[3-(2-Pyridyldithio)propionamido]hexanoate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Succinimidyl 6-[3-(2-Pyridyldithio)propionamido]hexanoate manufacturers
- Product
- SPDP-C6-NHS ester 158913-22-5
- Price
- US $0.00/mg
- Min. Order
- 50mg
- Purity
- >99.00%
- Supply Ability
- 50mg
- Release date
- 2024-03-21