2-(Tributylstannyl)pyrimidine
- Product Name
- 2-(Tributylstannyl)pyrimidine
- CAS No.
- 153435-63-3
- Chemical Name
- 2-(Tributylstannyl)pyrimidine
- Synonyms
- SKL1126;2-tributyltinpyrMidine;2-(tributyltin) pyrimidine;-(Tributylstannyl)pyrimidine;Tributyl(2-pyrimidyl)stannane;2-(Tributylstannanyl)pyrimidine;PyriMidine,2-(tributylstannyl)-;ributyl(pyrimidin-2-yl)stannane;2-(tri-n-butylstannyl)pyrimidine;(Pyrimidin-2-yl)tributylstannane
- CBNumber
- CB81177116
- Molecular Formula
- C16H30N2Sn
- Formula Weight
- 369.13
- MOL File
- 153435-63-3.mol
2-(Tributylstannyl)pyrimidine Property
- Boiling point:
- 381.2±25.0 °C(Predicted)
- Density
- 1.164 g/mL at 25 °C
- refractive index
- n20/D1.512
- Flash point:
- >110℃
- storage temp.
- Sealed in dry,2-8°C
- solubility
- soluble in Methanol; Ethyl Acetate; Dichloromethane; Chloroform; DMF; DMSO
- form
- liquid
- pka
- 1.42±0.33(Predicted)
- color
- Colourless
- InChI
- InChI=1S/C4H3N2.3C4H9.Sn/c1-2-5-4-6-3-1;3*1-3-4-2;/h1-3H;3*1,3-4H2,2H3;
- InChIKey
- WTFFOOAJSDVASL-UHFFFAOYSA-N
- SMILES
- C1([Sn](CCCC)(CCCC)CCCC)=NC=CC=N1
Safety
- Hazard Codes
- Xi,T,N
- Risk Statements
- 21-25-36/38-48/23/25-50/53
- Safety Statements
- 36/37/39-45-60-61-35
- RIDADR
- UN 2788 6.1 / PGIII
- WGK Germany
- 3
- HazardClass
- IRRITANT, TOXIC, KEEP COLD
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H372Causes damage to organs through prolonged or repeated exposure
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P202Do not handle until all safety precautions have been read and understood.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 721174
- Product name
- 2-(Tributylstannyl)pyrimidine
- Purity
- 95%
- Packaging
- 1g
- Price
- $146.3
- Updated
- 2025/07/31
- Product number
- 721174
- Product name
- 2-(Tributylstannyl)pyrimidine
- Purity
- 95%
- Packaging
- 5g
- Price
- $245
- Updated
- 2025/07/31
- Product number
- T773988
- Product name
- 2-(Tributylstannyl)pyrimidine
- Packaging
- 2.5g
- Price
- $385
- Updated
- 2021/12/16
- Product number
- 9H50-1-X8
- Product name
- 2-(Tributylstannyl)pyrimidine
- Purity
- 97%
- Packaging
- 250mg
- Price
- $35
- Updated
- 2021/12/16
- Product number
- 043836
- Product name
- 2-Tributylstannylpyrimidine
- Purity
- 95%
- Packaging
- 250mg
- Price
- $40
- Updated
- 2021/12/16
2-(Tributylstannyl)pyrimidine Chemical Properties,Usage,Production
Chemical Properties
Clear colorless liquid
Uses
2-(Tributylstannyl)pyrimidine is an organotin compound used in Stille coupling reaction. This can be used as one of the precursors in the synthesis of 2-aminopyridine oxazolidinones as potent and selective tankyrase (TNKS) inhibitors and the synthesis of canagliflozin, a novel inhibitor for sodium-dependent glucose cotransporter.
It can also be used in the preparation of various (2-pyrimidyl)silanes.
Synthesis
1722-12-9
688-73-3
153435-63-3
Under nitrogen protection, tributyltin hydride (12.5 g) was dissolved in 20 mL of anhydrous tetrahydrofuran in a round bottom flask. With stirring at 0 °C, 2M lithium diisopropylammonium (18.75 g) was slowly added with continuous stirring for 30 min. Subsequently, the reaction system was cooled to -18 °C and 2-chloropyrimidine (4 g, 35 mmol) dissolved in 20 mL of anhydrous tetrahydrofuran was slowly added dropwise. After the dropwise addition, the reaction system was gradually warmed to room temperature and stirring was continued for 12 hours. Upon completion of the reaction, the reaction was quenched by the addition of 30 mL of water and extracted with ethyl acetate. The organic phases were combined, concentrated under reduced pressure to remove the solvent, and finally purified by column chromatography to afford 2-(tributyltin)pyrimidine (11.68 g, 90% yield).
References
[1] Patent: KR2018/75381, 2018, A. Location in patent: Paragraph 0071; 0072-0074
[2] Patent: EP1724268, 2006, A1. Location in patent: Page/Page column 58; 77; 95
2-(Tributylstannyl)pyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
2-(Tributylstannyl)pyrimidine Suppliers
- Tel
- 028-85305008 02885305008
- Fax
- 4000210878-186
- 2306208234@qq.com
- Country
- China
- ProdList
- 1006
- Advantage
- 50
- Tel
- 025-58859352 18068836627
- Fax
- 02557626880
- sales01@aikonchem.com
- Country
- China
- ProdList
- 15083
- Advantage
- 58
- Tel
- 13776432722
- 358854490@qq.com
- Country
- China
- ProdList
- 39
- Advantage
- 58
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- +86 (519) 8689-6136
- Fax
- +86 (519) 8205-9235
- kr@krchemistar.com
- Country
- China
- ProdList
- 181
- Advantage
- 55
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11035
- Advantage
- 64
- Tel
- 025-83697070
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 15883
- Advantage
- 64
- Tel
- 4009903999 13355009207
- Fax
- 0539-6365991
- 3007715519@qq.com
- Country
- China
- ProdList
- 18729
- Advantage
- 57
- Tel
- +86 (21) 6435-5022
- Country
- China
- ProdList
- 4267
- Advantage
- 65
View Lastest Price from 2-(Tributylstannyl)pyrimidine manufacturers
- Product
- 2-(Tributylstannyl)pyrimidine 153435-63-3
- Price
- US $2.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100g , 1kg, 5kg , 50kg
- Release date
- 2020-01-07