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Mofegiline hydrochloride

Product Name
Mofegiline hydrochloride
CAS No.
120635-25-8
Chemical Name
Mofegiline hydrochloride
Synonyms
CS-1216;MDL72974A;Mofegiline HCl;Mofegiline hydrochloride;Mofegiline-hydrochloride, MDL72974A
CBNumber
CB81177499
Molecular Formula
C11H13F2N.ClH
Formula Weight
233.688
MOL File
120635-25-8.mol
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Mofegiline hydrochloride Property

Melting point:
131°
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Water: 30 mg/ml
form 
Powder
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-3195
Product name
Mofegilinehydrochloride
Packaging
5mg
Price
$114
Updated
2021/12/16
ChemScene
Product number
CS-3195
Product name
Mofegilinehydrochloride
Packaging
10mg
Price
$168
Updated
2021/12/16
ChemScene
Product number
CS-3195
Product name
Mofegilinehydrochloride
Packaging
50mg
Price
$504
Updated
2021/12/16
ChemScene
Product number
CS-3195
Product name
Mofegilinehydrochloride
Packaging
100mg
Price
$754
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0003417
Product name
MOFEGILINE HYDROCHLORIDE
Purity
95.00%
Packaging
0.25G
Price
$769
Updated
2021/12/16
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Mofegiline hydrochloride Chemical Properties,Usage,Production

Uses

Antiparkinsonian.

in vivo

Mofegiline hydrochloride (MDL72974A) (0.1-2.5 mg/kg; p.o.; single dose) inhibits MAO-B activity external vivo in rat model and (1.25 mg/kg; i.p.; 18 hours prior to MPTP treatment) exerts its ability to block MPTP neurotoxicity in mice model[1].

Animal Model:Male Sprague-Dawley rats (150-400 g)[1]
Dosage:Group 1: 0.1-2.5 mg/kg; Group 2: 0.05-5 mg/kg
Administration:Oral gavage; single dose for group 1, as for group 2, once daily for 14 days
Result:Showed the inhibition effect on rat brain MAO-A and MAO-B with EC50s of 8 mg/kg and 0.18 mg/kg, respectively, in group 1.
Resulted more potent efficacy on MAO-A inhibition in a daily dosed-manner (group 2) than single dose (group 1) manner, indicating a long half-life of Mofegiline hydrochloride.
Animal Model:Mate SwissWebster (CF-W) mice (25-30 g)[1]
Dosage:1.25 mg/kg
Administration:Intraperitoneal injection; 18 hours prior to administration of MPTP (20 mg/kg; i.p.; 4 times for two-hourly intervals, for 8 days)
Result:Rescued MPTP-induced decreases in striatal levels of dopamine (DA), dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in mice.
Animal Model:Male Sprague-Dawley rats (150-400 g) injected with Tyramine (HY-W007606) (1.25-80 μg/kg; i.v.)[1]
Dosage:Group 1: 1.8, 9 mg/kg; Group 2: 0.1, 1 mg/kg
Administration:Oral gavage; single dose for group 1, as for group 2, once daily for 14 days
Result:Did not significantly potentiate the cardiovascular effects of intraduodenally administered Tyramine (HY-W007606) in anaesthetised rats.

Mofegiline hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Mofegiline hydrochloride Suppliers

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120635-25-8, Mofegiline hydrochlorideRelated Search:

Selegiline Rasagiline 4-(4-FLUOROPHENYL)-1-BUTENE Benzene, 1-fluoro-4-(3-methyl-3-butenyl)- (9CI) Mofegiline Mofegiline hydrochloride

  • Mofegiline hydrochloride
  • Mofegiline HCl
  • CS-1216
  • Mofegiline-hydrochloride, MDL72974A
  • MDL72974A
  • 120635-25-8
  • Antiparkinsonian
  • Inhibitor