ChemicalBook > CAS DataBase List > Mofegiline hydrochloride
Mofegiline hydrochloride
- Product Name
- Mofegiline hydrochloride
- CAS No.
- 120635-25-8
- Chemical Name
- Mofegiline hydrochloride
- Synonyms
- CS-1216;MDL72974A;Mofegiline HCl;Mofegiline hydrochloride;Mofegiline-hydrochloride, MDL72974A
- CBNumber
- CB81177499
- Molecular Formula
- C11H13F2N.ClH
- Formula Weight
- 233.688
- MOL File
- 120635-25-8.mol
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Mofegiline hydrochloride Property
- Melting point:
- 131°
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Water: 30 mg/ml
- form
- Powder
- color
- White to off-white
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-3195
- Product name
- Mofegilinehydrochloride
- Packaging
- 5mg
- Price
- $114
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-3195
- Product name
- Mofegilinehydrochloride
- Packaging
- 10mg
- Price
- $168
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-3195
- Product name
- Mofegilinehydrochloride
- Packaging
- 50mg
- Price
- $504
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-3195
- Product name
- Mofegilinehydrochloride
- Packaging
- 100mg
- Price
- $754
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- API0003417
- Product name
- MOFEGILINE HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 0.25G
- Price
- $769
- Updated
- 2021/12/16
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Mofegiline hydrochloride Chemical Properties,Usage,Production
Uses
Antiparkinsonian.
in vivo
Mofegiline hydrochloride (MDL72974A) (0.1-2.5 mg/kg; p.o.; single dose) inhibits MAO-B activity external vivo in rat model and (1.25 mg/kg; i.p.; 18 hours prior to MPTP treatment) exerts its ability to block MPTP neurotoxicity in mice model[1].
| Animal Model: | Male Sprague-Dawley rats (150-400 g)[1] |
| Dosage: | Group 1: 0.1-2.5 mg/kg; Group 2: 0.05-5 mg/kg |
| Administration: | Oral gavage; single dose for group 1, as for group 2, once daily for 14 days |
| Result: | Showed the inhibition effect on rat brain MAO-A and MAO-B with EC50s of 8 mg/kg and 0.18 mg/kg, respectively, in group 1. Resulted more potent efficacy on MAO-A inhibition in a daily dosed-manner (group 2) than single dose (group 1) manner, indicating a long half-life of Mofegiline hydrochloride. |
| Animal Model: | Mate SwissWebster (CF-W) mice (25-30 g)[1] |
| Dosage: | 1.25 mg/kg |
| Administration: | Intraperitoneal injection; 18 hours prior to administration of MPTP (20 mg/kg; i.p.; 4 times for two-hourly intervals, for 8 days) |
| Result: | Rescued MPTP-induced decreases in striatal levels of dopamine (DA), dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in mice. |
| Animal Model: | Male Sprague-Dawley rats (150-400 g) injected with Tyramine (HY-W007606) (1.25-80 μg/kg; i.v.)[1] |
| Dosage: | Group 1: 1.8, 9 mg/kg; Group 2: 0.1, 1 mg/kg |
| Administration: | Oral gavage; single dose for group 1, as for group 2, once daily for 14 days |
| Result: | Did not significantly potentiate the cardiovascular effects of intraduodenally administered Tyramine (HY-W007606) in anaesthetised rats. |
Mofegiline hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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Mofegiline hydrochloride Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
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