Lometrexol

Product Name: Lometrexol
CAS No.: 106400-81-1
Chemical Name: Lometrexol
Synonyms: LY 264618;Lometrexol;Lometrexolum;LY 264618 hydrate;Lometrexol hydrate;Lometrexol(LY 264618);Lometrexolum [inn-latin];(6R)-5,10-Dideaza-5,6,7,8-tetrahydrofolic acid;N-[4-[2-[[(R)-2-Amino-4-oxo-1,4,5,6,7,8-hexahydropyrido[2,3-d]pyrimidin]-6-yl]ethyl]benzoyl]-L-glutamic acid;L-Glutamic acid, N-(4-(2-((6R)-2-amino-1,4,5,6,7,8-hexahydro-4-oxopyrido(2,3-D)pyrimidin-6-yl)ethyl)benzoyl)-
CBNumber: CB81179064
Molecular Formula: C21H25N5O6
Formula Weight: 443.45
MOL File: 106400-81-1.mol

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Lometrexol Property

Density: 1.56±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: ≥5mg/mL
pka: 3.60±0.10(Predicted)
form: powder
color: white to light yellow
Stability:: Hygroscopic

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0040
Product name: Lometrexol hydrate
Purity: ≥95% (HPLC)
Packaging: 5mg
Price: $254
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0040
Product name: Lometrexol hydrate
Purity: ≥95% (HPLC)
Packaging: 25mg
Price: $666
Updated: 2024/03/01

Cayman Chemical

Product number: 18049
Product name: Lometrexol
Purity: ≥98%
Packaging: 1mg
Price: $97
Updated: 2024/03/01

Cayman Chemical

Product number: 18049
Product name: Lometrexol
Purity: ≥98%
Packaging: 5mg
Price: $243
Updated: 2024/03/01

ChemScene

Product number: CS-0003423
Product name: Lometrexol
Packaging: 1mg
Price: $275
Updated: 2021/12/16

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Lometrexol Chemical Properties,Usage,Production

Description

Glycinamide ribonucleotide formyltransferase (GART) is a folate-dependent enzyme required for de novo purine synthesis. Lometrexol is a folate analog antimetabolite with antineoplastic activity. At nanomolar conentrations, it inhibits GART preventing de novo purine synthesis, inhibiting DNA synthesis, arresting cells in the S phase of the cell cycle, and inhibiting tumor cell proliferation.

Uses

Lometrexol hydrate was used to compare the biological activity of potent inhibitor of human GARFTase.

Uses

It is an antifolate which inhibits glycinamide ribonucleotide formyltransferase (GARFT), an enzyme essential for de novo purine synthesis.

Biochem/physiol Actions

Glycinamide Ribonucleotide Formyltransferase (GARFTase) is a folate-dependent enzyme required for de novo purine synthesis. Lometrexate is a potent inhibitor of GARFTase, but does not interfere with enzymes involved in the synthesis of folate. Lometrexerol has been tested clinically for the treatment of various cancers as an anti-folate like agent, similar to methotrexate. Treatment with lometrexol rapidly decreases ATP and GTP levels, cell cycle arrest and induces apoptosis. Although depletion of nucleotide pools induces p53 expression, lometrexol is cytotoxic in both wild-type and mutant p53 expressing tumor cells. Lometrexol is cytotoxic in CCRF-CEm leukemia cells with an IC50 of 2.9 nM.

Lometrexol Preparation Products And Raw materials

Raw materials

Preparation Products

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Lometrexol Suppliers

Canada 1 China 20 India 1 United States 6 Global 28

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106400-81-1, LometrexolRelated Search:

L-Tetrahydrofolic Acid CHEMBRDG-BB 9071517 Lometrexol 4-n-Hexylbenzylamine CHEMBRDG-BB 9071469 4-PENTYLBENZYLAMINE CHEMBRDG-BB 9071952 2,4-Diamino-6-hydroxypyrimidine 4-N-BUTYLBENZYLAMINE 4-N-BUTYLBENZAMIDE 1,4,5,6-TETRAHYDRO-3-PYRIDINECARBOXAMIDE

Lometrexol

(6R)-5,10-Dideaza-5,6,7,8-tetrahydrofolic acid

N-[4-[2-[[(6R)-2-Amino-3,4,5,6,7,8-hexahydro-4-oxopyrido[2,3-d]pyrimidin]-6-yl]ethyl]benzoyl]-L-glutamic acid

N-[4-[2-[[(R)-2-Amino-4-oxo-1,4,5,6,7,8-hexahydropyrido[2,3-d]pyrimidin]-6-yl]ethyl]benzoyl]-L-glutamic acid

L-Glutamic acid, N-(4-(2-((6R)-2-amino-1,4,5,6,7,8-hexahydro-4-oxopyrido(2,3-D)pyrimidin-6-yl)ethyl)benzoyl)-

L-Glutamic acid, N-(4-(2-(2-amino-1,4,5,6,7,8-hexahydro-4-oxopyrido(2,3-D)pyrimidin-6-yl)ethyl)benzoyl)-, (R)-

Lometrexolum

Lometrexolum [inn-latin]

LY 264618

Lometrexol hydrate

LY 264618 hydrate

N-[4-[2-[(6R)-2-amino-3,4,5,6,7,8-hexahydro-4-oxopyrido[2,3-d]pyrimidin-6-yl]ethyl]benzoyl]-L-glutamic acid hydrate

Lometrexol(LY 264618)

L-Glutamic acid, N-[4-[2-[(6R)-2-amino-3,4,5,6,7,8-hexahydro-4-oxopyrido[2,3-d]pyrimidin-6-yl]ethyl]benzoyl]-

106400-81-1

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