Nemadectin

Product Name: Nemadectin
CAS No.: 102130-84-7
Chemical Name: Nemadectin
Synonyms: AC-088;Nimoxetine;Nemadectin;LL-F-28249α;LL-F28249 alpha;S541A, LL-F28249 alpha;(6R,23S,25S)-5-O-Demethyl-28-deoxy-25-[(E)-1,3-dimethyl-1-butenyl]-6,28-epoxy-23-hydroxymilbemycin B;Milbemycin B,5-O-demethyl-28-deoxy-25-[(1E)-1,3-dimethyl-1-buten-1-yl]-6,28-epoxy-23-hydroxy-,(6R,23S)-;(2R,2a'E,2a1'S,4S,4'E,5S,6S,6'R,8'E,11'R,15'S,17a'R,20'R,20a'R)-2a1',4,20'-Trihydroxy-5,6',8',19'-tetramethyl-6-((E)-4-methylpent-2-en-2-yl)-2a1',3,4,5,6,6',7',10',11',14',15',17a',20',20a'-tetradecahydro-2'H,17'H-spiro[pyran-2,13'-[11,15]methano[1,5]dioxacyclooctadecino[9,8,7-cd]benzofuran]-17'-one;(2R,2a'E,2a1'S,4S,4'E,5S,6S,6'R,8'E,11'R,15'S,17a'R,20'R,20a'R)-2a1',4,20'-Trihydroxy-5,6',8',19'-tetramethyl-6-((E)-4-methylpent-2-en-2-yl)-2a1',3,4,5,6,6',7',10',11',14',15',17a',20',20a'-tetradecahydro-2'H,17'H-spiro[pyran-2,13'-[11,15]methano[1,5]dioxacyclooctadecino[9,8,7-cd]benzofuran]-17'-one
CBNumber: CB81179291
Molecular Formula: C36H52O8
Formula Weight: 612.79
MOL File: 102130-84-7.mol

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Nemadectin Property

alpha: D26 +133° (c = 0.3 in acetone)
Boiling point:: 789.4±60.0 °C(Predicted)
Density: 1.20±0.1 g/cm3(Predicted)
pka: 12.46±0.70(Predicted)
form: Solid
color: White to off-white
InChIKey: YNFMRVVYUVPIAN-JUOPSJISNA-N

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Safety

RIDADR: 2588
HazardClass: 6.1(b)
PackingGroup: III

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 17454
Product name: Nemadectin
Purity: ≥95%
Packaging: 1mg
Price: $265
Updated: 2021/12/16

Cayman Chemical

Product number: 17454
Product name: Nemadectin
Purity: ≥95%
Packaging: 5mg
Price: $928
Updated: 2021/12/16

Usbiological

Product number: 285448
Product name: Nemadectin
Packaging: 1mg
Price: $1214
Updated: 2021/12/16

Usbiological

Product number: N0980
Product name: Nemadectin
Packaging: 1mg
Price: $561
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD32725
Product name: (6R,23S,25S)-5-O-Demethyl-28-Deoxy-25-((E)-1,3-Dimethyl-1-Butenyl)-6,28-Epoxy-23-Hydroxymilbemycin B
Packaging: 2mg
Price: $700
Updated: 2021/12/16

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Nemadectin Chemical Properties,Usage,Production

Description

The nemadectins are fermentation products of Streptomyces cyaneogriseus noncyanogenus. Structurally, the nemadectins lack a disaccharide group at C-13 but differ from the milbemycins proper because they contain a trisubstituted double bond at C-26 in their side chains.

Uses

Nemadectin is a potent antiparasitic macrolide lactone.

Uses

Nemadectin is the dominant member of a class of milbemycins bearing unsaturated longer chain groups at the 25-position. Nemadectin shows pronounced nematocidal and insecticidal activity. Nemadectin is the starting material for moxidectin, a commercial anthelmintic.

in vivo

Nemadectin is highly effective at 0.6 mg/kg BW against natural infections of all major species of canine intestinal helminths, when administered as a single oral dose, either as a liquid or a tablet^[1].

IC 50

Mite

Nemadectin Preparation Products And Raw materials

Raw materials

Preparation Products

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Nemadectin Suppliers

China 66 India 1 United Kingdom 2 United States 7 Global 76

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Raw material medicin reagent co.,Ltd

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102130-84-7, NemadectinRelated Search:

trans-3-Hydroxyhex-4-enoic acid, min. 95 % (1H-NMR) HEPTA-4,6-DIENOIC ACID LAVANDULOL Nemadectin CARVEOL MILBEMECTIN A3 (E)-HEPTA-4,6-DIENOIC ACID ETHYL ESTER 2-PROPYL-3-PENTENOIC ACID (+/-)-LAVANDULOL METHYL HEPTA-4,6-DIENOATE ETHYL 2-METHYL-3-PENTENOATE (+)-Dipentene FEMA 3693 MILBEMECTIN A4

Nemadectin

(6R,23S,25S)-5-O-Demethyl-28-deoxy-25-[(E)-1,3-dimethyl-1-butenyl]-6,28-epoxy-23-hydroxymilbemycin B

AC-088

LL-F-28249α

S541A, LL-F28249 alpha

LL-F28249 alpha

Milbemycin B,5-O-demethyl-28-deoxy-25-[(1E)-1,3-dimethyl-1-buten-1-yl]-6,28-epoxy-23-hydroxy-,(6R,23S)-

(2R,2a'E,2a1'S,4S,4'E,5S,6S,6'R,8'E,11'R,15'S,17a'R,20'R,20a'R)-2a1',4,20'-Trihydroxy-5,6',8',19'-tetramethyl-6-((E)-4-methylpent-2-en-2-yl)-2a1',3,4,5,6,6',7',10',11',14',15',17a',20',20a'-tetradecahydro-2'H,17'H-spiro[pyran-2,13'-[11,15]methano[1,5]dioxacyclooctadecino[9,8,7-cd]benzofuran]-17'-one

Nimoxetine

(2R,2a'E,2a1'S,4S,4'E,5S,6S,6'R,8'E,11'R,15'S,17a'R,20'R,20a'R)-2a1',4,20'-Trihydroxy-5,6',8',19'-tetramethyl-6-((E)-4-methylpent-2-en-2-yl)-2a1',3,4,5,6,6',7',10',11',14',15',17a',20',20a'-tetradecahydro-2'H,17'H-spiro[pyran-2,13'-[11,15]methano[1,5]dioxacyclooctadecino[9,8,7-cd]benzofuran]-17'-one

102130-84-7