ChemicalBook > CAS DataBase List > Vanoxerine

Vanoxerine

Product Name
Vanoxerine
CAS No.
67469-69-6
Chemical Name
Vanoxerine
Synonyms
Vanoxerine free base;1-(2-(di(4-fluorophenyl)-methoxy)-ethyl)-4-(3-phenylpropyl)piperazine;Piperazine, 1-[2-[bis(4-fluorophenyl)Methoxy]ethyl]-4-(3-phenylpropyl)-
CBNumber
CB81180039
Molecular Formula
C28H32F2N2O
Formula Weight
450.56
MOL File
67469-69-6.mol
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Vanoxerine Property

Boiling point:
542.7±50.0 °C(Predicted)
Density 
1.135±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Powder
pka
7.55±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ApexBio Technology
Product number
B3249
Product name
Vanoxerine
Packaging
25mg
Price
$156
Updated
2021/12/16
CSNpharm
Product number
CSN12187
Product name
Vanoxerine
Packaging
50mg
Price
$190
Updated
2021/12/16
Crysdot
Product number
CD31001100
Product name
Vanoxerine
Purity
98+%
Packaging
50mg
Price
$450
Updated
2021/12/16
AvaChem
Product number
2889B
Product name
Vanoxerine
Packaging
1g
Price
$575
Updated
2021/12/16
AvaChem
Product number
2889B
Product name
Vanoxerine
Packaging
5g
Price
$1950
Updated
2021/12/16
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Vanoxerine Chemical Properties,Usage,Production

Definition

ChEBI: Vanoxerine is an N-alkylpiperazine that consists of piperazine bearing 2-bis(4-fluorophenyl)methoxy]ethyl and 3-phenylpropyl groups at positions 1 and 4 respectively. Potent, competitive inhibitor of dopamine uptake (Ki = 1 nM for inhibition of striatal dopamine uptake). Has > 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigma ligand (IC50 = 48 nM). Centrally active following systemic administration. It has a role as a dopamine uptake inhibitor. It is a N-alkylpiperazine, an organofluorine compound, a tertiary amino compound and an ether. It is a conjugate base of a vanoxerine(2+).

Biological Activity

vanoxerine is an antagonist of dopamine transporter (dat1) with ki value of 16.9nm [1].as an antagonist of dat, vanoxerine is developed for treatment of parkinson's disease and depression but has no effect on these diseases. vanoxerine is also found to have desirable cardiac antiarrhythmic properties. it is a blocker of cardiac herg (hkv11.1) with ic50 value of 0.84nm. it also blocks the ica,l and hnav1.5 channel with ic50 values of 320nm and 830nm, respectively. vanoxerine does not significantly prolong purkinje fiber apd60 and apd90 and has no significant effect on qt or tdr. further, the

References

[1] giros b, el mestikawy s, godinot n, zheng k, han h, yang-feng t, caron mg. cloning, pharmacological characterization, and chromosome assignment of the human dopamine transporter. mol pharmacol. 1992 sep;42(3):383-90.
[2] lacerda ae, kuryshev ya, yan gx, waldo al, brown am. vanoxerine: cellular mechanism of a new antiarrhythmic. j cardiovasc electrophysiol. 2010 mar;21(3):301-10.

Vanoxerine Preparation Products And Raw materials

Raw materials

Preparation Products

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Vanoxerine Suppliers

Hangzhou Sage Chemical Co., Ltd.
Tel
+86057186818502 13588463833
Fax
Pls mail us for more information!
Email
info@sagechem.com
Country
China
ProdList
10266
Advantage
58
LETOPHARM LIMITED
Tel
+86-21-5821 5861
Fax
+86-21-5106 2861
Email
sales@letopharm.com
Country
China
ProdList
2384
Advantage
58
SPIRO PHARMA
Tel
Fax
-
Email
eric_feng1954@126.com
Country
China
ProdList
9248
Advantage
55
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
Absin Bioscience Inc.
Tel
021-38015121 15000105423
Email
wulan@absin.cn
Country
China
ProdList
24731
Advantage
58
Shanghai Botuo Biotechnology Co., LTD
Tel
16621358918
Fax
QQ:402135374
Email
botuopharma888@163.com
Country
China
ProdList
9208
Advantage
58
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
8140
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24644
Advantage
58

67469-69-6, VanoxerineRelated Search:


  • Piperazine, 1-[2-[bis(4-fluorophenyl)Methoxy]ethyl]-4-(3-phenylpropyl)-
  • 1-(2-(di(4-fluorophenyl)-methoxy)-ethyl)-4-(3-phenylpropyl)piperazine
  • Vanoxerine free base
  • 67469-69-6
  • C28H32F2N2O