4,4'-Difluorobenzhydrol
- Product Name
- 4,4'-Difluorobenzhydrol
- CAS No.
- 365-24-2
- Chemical Name
- 4,4'-Difluorobenzhydrol
- Synonyms
- 4,4-DIFLUOROBENZHYDROL;4,4'-Difluorobenzhyd;4’4-Difluorobenzhydrd;LABOTEST-BB LT00233218;Flunarizine Impurity 8;Flunarizine Impurity 4;2,4-pyridinediolC5H5NO2;4,4'-Difluorobenzhydrol;Difluorodiphenylmethanol;4,4'-difluorodibenzohydrol
- CBNumber
- CB4245331
- Molecular Formula
- C13H10F2O
- Formula Weight
- 220.21
- MOL File
- 365-24-2.mol
4,4'-Difluorobenzhydrol Property
- Melting point:
- 43-45 °C(lit.)
- Boiling point:
- 143 °C3 mm Hg(lit.)
- Density
- 1.2031 (estimate)
- Flash point:
- >230 °F
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 13.41±0.20(Predicted)
- color
- White to Light yellow
- BRN
- 2332258
- InChI
- InChI=1S/C13H10F2O/c14-11-5-1-9(2-6-11)13(16)10-3-7-12(15)8-4-10/h1-8,13,16H
- InChIKey
- WCTZPQWLFWZYJE-UHFFFAOYSA-N
- SMILES
- C(O)(C1C=CC(F)=CC=1)C1C=CC(F)=CC=1
- CAS DataBase Reference
- 365-24-2(CAS DataBase Reference)
- NIST Chemistry Reference
- 4,4'-Difluorobenzhydrol(365-24-2)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 22-24/25-36/37-26
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29062900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 222682
- Product name
- Bis(4-fluorophenyl)methanol
- Purity
- 98%
- Packaging
- 5g
- Price
- $41.57
- Updated
- 2025/07/31
- Product number
- D1795
- Product name
- 4,4'-Difluorobenzhydrol
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $79
- Updated
- 2025/07/31
- Product number
- B434870
- Product name
- Bis(4-fluorophenyl)methanol
- Packaging
- 2.5g
- Price
- $65
- Updated
- 2021/12/16
- Product number
- FD38587
- Product name
- 4,4'-Difluorobenzhydrol
- Packaging
- 250g
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 006462
- Product name
- 4,4'-Difluorobenzhydrol
- Purity
- 98%
- Packaging
- 25g
- Price
- $14
- Updated
- 2021/12/16
4,4'-Difluorobenzhydrol Chemical Properties,Usage,Production
Chemical Properties
white to yellowish crystalline flakes or powder
Uses
4-Chloropyridine-3-sulfonyl Chloride can be used for antiinflammatory properties.
General Description
Bis(4-fluorophenyl)methanol is one of the degardation product of flunarizine hydrochloride (FLZ).
Synthesis
345-92-6
365-24-2
GENERAL METHODS: NaBH4 (0.6 mol) was added batchwise to a stirred solution of 4,4'-difluorobenzophenone (1.0 mol) in methanol (2 volumes) at room temperature for 45 min. The reaction mixture was stirred at ambient temperature for 2-3 h (progress of the reaction was monitored by TLC), and upon completion of the reaction, the reaction was diluted with water (750 mL), the pH was adjusted to 4 with acetic acid, and the reaction was subsequently extracted with dichloromethane (2 x 400 mL). The organic layer was washed with water (200 mL), dried with anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to give pure 4,4'-difluorodiphenylmethanol as a white to off-white solid in 93-97% yield. To a stirred solution of 4,4'-difluorodiphenylmethanol (1.0 mol) in toluene (370 mL) at room temperature was added concentrated hydrochloric acid (35% aqueous, 370 mL) and tetrabutylammonium bromide (0.01 mol). The mixture was continued to be stirred at 40-45 °C for 6-7 h. After TLC showed that the reaction was complete, the mixture was cooled to room temperature. The organic layer was separated and concentrated under vacuum to give crude 4,4'-difluorodiphenylmethyl chloride as a light brown liquid in 95-97% yield. Anhydrous piperazine (5.0 mol) was slowly added to a solution of 4,4'-difluorodiphenylmethyl chloride (0.96 mol) in toluene (380 mL) at 60-70 °C for 45-60 minutes. The resulting mixture was heated at 90-100°C for 8-10 hours with stirring. After completion of the reaction the mixture was cooled and water (380 mL) was added to separate the organic layer. The organic layer was washed with a 1:1 mixture of concentrated hydrochloric acid and water (2 x 350 mL) and subsequently neutralized with 20% NaOH solution (750 mL). The aqueous layer was again extracted with toluene (2×300 mL), and the organic layers were combined, dried with anhydrous sodium sulfate, and concentrated in vacuum to afford the pure 4,4'-difluorodiphenylmethylpiperazine derivative as a white to off-white solid in 88% yield.
References
[1] Organic and Biomolecular Chemistry, 2018, vol. 16, # 28, p. 5094 - 5096
[2] Synthesis, 2010, # 12, p. 1989 - 1991
[3] Synthetic Communications, 2014, vol. 44, # 5, p. 600 - 609
[4] Organic Letters, 2000, vol. 2, # 5, p. 659 - 661
[5] Patent: , 2016, . Location in patent: Paragraph 0016; 0018; 0019; 0020; 0021; 0022
4,4'-Difluorobenzhydrol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4,4'-Difluorobenzhydrol manufacturers
- Product
- 4,4'-Difluorobenzhydrol 365-24-2
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 ton
- Release date
- 2024-11-18
- Product
- 4,4'-Difluorobenzhydrol 365-24-2
- Price
- US $5.00-2.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-08-22
- Product
- 4,4'-Difluorobenzhydrol 365-24-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20t
- Release date
- 2024-06-18