ChemicalBook > CAS DataBase List > 1-Propanone, 3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)-

1-Propanone, 3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)-

Product Name
1-Propanone, 3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)-
CAS No.
273727-89-2
Chemical Name
1-Propanone, 3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)-
Synonyms
1-Propanone, 3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)-
CBNumber
CB81216044
Molecular Formula
C23H25NO
Formula Weight
331.45
MOL File
273727-89-2.mol
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1-Propanone, 3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)- Property

Boiling point:
478.8±28.0 °C(Predicted)
Density 
1.083±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
pka
7.99±0.50(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
KIN0000976
Product name
ZM-39923
Purity
95.00%
Packaging
10MG
Price
$702.19
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
KIN0000976
Product name
ZM-39923
Purity
95.00%
Packaging
50MG
Price
$1199.42
Updated
2021/12/16
DC Chemicals
Product number
DC24070
Product name
ZM39923
Purity
>98%
Packaging
10mg
Price
$98
Updated
2021/12/16
DC Chemicals
Product number
DC24070
Product name
ZM39923
Purity
>98%
Packaging
100mg
Price
$468
Updated
2021/12/16
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1-Propanone, 3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)- Chemical Properties,Usage,Production

Uses

ZM39923 is a JAK3 inhibitor, with a pIC50 of 7.1; ZM39923 also potently inhibits tissue transglutaminase (TGM2) with an IC50 of 10 nM.

Definition

ChEBI: 1-(2-naphthalenyl)-3-[(phenylmethyl)-propan-2-ylamino]-1-propanone is a member of naphthalenes.

IC 50

JAK3: 7.1 (pIC50); JAK1: 4.4 (pIC50); EGF-R: 5.6 (pIC50); Lck: 5.0 (pIC50); CDK4: 5.0 (pIC50); TGM2: 10 nM (IC50)

References

[1] Brown GR, et al. Naphthyl ketones: a new class of Janus kinase 3 inhibitors. Bioorg Med Chem Lett. 2000 Mar 20;10(6):575-9. DOI:10.1016/s0960-894x(00)00051-2
[2] Lai TS, et al. Identification of chemical inhibitors to human tissue transglutaminase by screening existing drug libraries. Chem Biol. 2008 Sep 22;15(9):969-78. DOI:10.1016/j.chembiol.2008.07.015
[3] Zhang Z, et al. Jak3 is involved in CCR7-dependent migration and invasion in metastatic squamous cell carcinoma of the head and neck. Oncol Lett. 2017 May;13(5):3191-3197. DOI:10.3892/ol.2017.5861

1-Propanone, 3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Propanone, 3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)- Suppliers

China 13 Germany 1 United States 3 Global 17
Synchem OHG
Tel
+49 5662 408730
Fax
+49 5662 4087320
Email
info@synchem.de
Country
Germany
ProdList
4705
Advantage
70

273727-89-2, 1-Propanone, 3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)-Related Search:

Naftifine Impurity 8 ZM 39923 HCl 1-Propanone, 3-[methyl(phenylmethyl)amino]-1-phenyl- 3-[Methyl(1-naphthalenylmethyl)amino]-1-phenyl-1-Propanone ZM 39923 HYDROCHLORIDE 1-Propanone, 3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)-

  • 1-Propanone, 3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)-
  • 273727-89-2