1-Propanone, 3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)-
- Product Name
- 1-Propanone, 3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)-
- CAS No.
- 273727-89-2
- Chemical Name
- 1-Propanone, 3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)-
- Synonyms
- 1-Propanone, 3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)-
- CBNumber
- CB81216044
- Molecular Formula
- C23H25NO
- Formula Weight
- 331.45
- MOL File
- 273727-89-2.mol
1-Propanone, 3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)- Property
- Boiling point:
- 478.8±28.0 °C(Predicted)
- Density
- 1.083±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 7.99±0.50(Predicted)
N-Bromosuccinimide Price
- Product number
- KIN0000976
- Product name
- ZM-39923
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $702.19
- Updated
- 2021/12/16
- Product number
- KIN0000976
- Product name
- ZM-39923
- Purity
- 95.00%
- Packaging
- 50MG
- Price
- $1199.42
- Updated
- 2021/12/16
- Product number
- DC24070
- Product name
- ZM39923
- Purity
- >98%
- Packaging
- 10mg
- Price
- $98
- Updated
- 2021/12/16
- Product number
- DC24070
- Product name
- ZM39923
- Purity
- >98%
- Packaging
- 100mg
- Price
- $468
- Updated
- 2021/12/16
1-Propanone, 3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)- Chemical Properties,Usage,Production
Uses
ZM39923 is a JAK3 inhibitor, with a pIC50 of 7.1; ZM39923 also potently inhibits tissue transglutaminase (TGM2) with an IC50 of 10 nM.
Definition
ChEBI: 1-(2-naphthalenyl)-3-[(phenylmethyl)-propan-2-ylamino]-1-propanone is a member of naphthalenes.
IC 50
JAK3: 7.1 (pIC50); JAK1: 4.4 (pIC50); EGF-R: 5.6 (pIC50); Lck: 5.0 (pIC50); CDK4: 5.0 (pIC50); TGM2: 10 nM (IC50)
References
[1] Brown GR, et al. Naphthyl ketones: a new class of Janus kinase 3 inhibitors. Bioorg Med Chem Lett. 2000 Mar 20;10(6):575-9. DOI:10.1016/s0960-894x(00)00051-2
[2] Lai TS, et al. Identification of chemical inhibitors to human tissue transglutaminase by screening existing drug libraries. Chem Biol. 2008 Sep 22;15(9):969-78. DOI:10.1016/j.chembiol.2008.07.015
[3] Zhang Z, et al. Jak3 is involved in CCR7-dependent migration and invasion in metastatic squamous cell carcinoma of the head and neck. Oncol Lett. 2017 May;13(5):3191-3197. DOI:10.3892/ol.2017.5861
1-Propanone, 3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)- Preparation Products And Raw materials
Raw materials
Preparation Products
1-Propanone, 3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)- Suppliers
- Tel
- +49 5662 408730
- Fax
- +49 5662 4087320
- info@synchem.de
- Country
- Germany
- ProdList
- 4705
- Advantage
- 70
- Tel
- 021-31433387 15618786686
- Fax
- QQ:1369748377
- sales@rechemscience.com
- Country
- China
- ProdList
- 2991
- Advantage
- 58
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 0519-83246372 13585352506
- Fax
- 0519-83246372
- Country
- China
- ProdList
- 1844
- Advantage
- 58
- Tel
- +1-800-259-7612
- Fax
- +1-800-259-7612
- info@musechem.com
- Country
- United States
- ProdList
- 4660
- Advantage
- 60
- Tel
- 15911056312
- liming@bio-fount.com
- Country
- China
- ProdList
- 9729
- Advantage
- 58
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32435
- Advantage
- 58
- Tel
- 010-60605840 15801484223;
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 29757
- Advantage
- 58
- Tel
- 0513-66337626 18051384581
- sales@chemhifuture.com
- Country
- China
- ProdList
- 5929
- Advantage
- 58
- Tel
- 025-85560043 15850508050
- Fax
- 025-85563444
- cindy.huang@synzest.com
- Country
- China
- ProdList
- 12000
- Advantage
- 58