ISOXATHION
- Product Name
- ISOXATHION
- CAS No.
- 18854-01-8
- Chemical Name
- ISOXATHION
- Synonyms
- e-48;si-6711;KARPHOS;HSDB6692;HSDB 6692;HSDB-6692;ISOXATHION;Isoxathion 0.1;ISOXATHION STANDARD;Propargite Impurity 8
- CBNumber
- CB8122146
- Molecular Formula
- C13H16NO4PS
- Formula Weight
- 313.31
- MOL File
- 18854-01-8.mol
ISOXATHION Property
- Melting point:
- <25℃
- Boiling point:
- 160°C (rough estimate)
- Density
- 1.48 g/ml
- vapor pressure
- <1.3 x 10-4 Pa (25 °C)
- storage temp.
- 0-6°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- Water Solubility
- 1.9 mg l-1 (25 °C)
- pka
- -6.17±0.28(Predicted)
- form
- liquid
- color
- Colourless to Pale Yellow
- Specific Gravity
- 1.48
- BRN
- 1222135
- EPA Substance Registry System
- Isoxathion (18854-01-8)
Safety
- Hazard Codes
- T,N
- Risk Statements
- 24/25-50/53
- Safety Statements
- 28-36/37-45-60-61
- RIDADR
- 3018
- WGK Germany
- 3
- HazardClass
- 6.1(b)
- PackingGroup
- III
- HS Code
- 29349990
- Hazardous Substances Data
- 18854-01-8(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- 76529
- Product name
- Isoxathion
- Purity
- analytical standard
- Packaging
- 25mg
- Price
- $245
- Updated
- 2022/05/15
- Product number
- I917690
- Product name
- Isoxathion
- Packaging
- 10mg
- Price
- $720
- Updated
- 2021/12/16
- Product number
- PST0000383
- Product name
- ISOXATHION
- Purity
- 98.00%
- Packaging
- 50ML
- Price
- $2695
- Updated
- 2021/12/16
- Product number
- CDX-I0049-M500
- Product name
- Isoxathion
- Purity
- ≥98%(HPLC)
- Packaging
- 500mg
- Price
- $565
- Updated
- 2021/12/16
- Product number
- CDX-I0049-M100
- Product name
- Isoxathion
- Purity
- ≥98%(HPLC)
- Packaging
- 100mg
- Price
- $141
- Updated
- 2021/12/16
ISOXATHION Chemical Properties,Usage,Production
Description
Isoxathion is a pale yellow liquid, bp 160 C/0.15 mm Hg, vp <0.133mPa (25 C). Solubility in water is 1.9 mg/L (25 C). It is readily soluble in most organic solvents. Log Kow = 3.88. It is unstable to alkali.
Uses
Isoxathion is used as a pesticide.
Uses
Isoxathion is used to control sucking pests, leaf miners and some chewing pests in a variety of fruit, vegetables and ornamental plants.
Definition
ChEBI: An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group is replaced by a 5-phenyl-1,2-oxazol-3-yl group.
Synthesis
The industrial production of isoxathion begins with the synthesis of a substituted phenol derivative, which undergoes thiophosphorylation using reagents such as O,O-dimethyl phosphorochloridothioate to introduce the organophosphate moiety. This step is typically carried out under controlled temperature and anhydrous conditions to prevent hydrolysis and ensure high yield. The resulting intermediate is then subjected to aromatic substitution with a heterocyclic compound, often a pyridyl or thiazole derivative, to enhance insecticidal potency and selectivity.
Metabolic pathway
The principal route of isoxathion metabolism in soil, plants and mammals is by hydrolysis, probably via the oxon to 3-hydroxy-5-phenylisoxazole which is rapidly conjugated in both plants and rats. In soils, and to a lesser extent in plants and mammals, further metabolism of 3-hydroxy- 5-phenylisoxazole proceeds via opening of the isoxazole ring to give various metabolites of which benzoic acid is one of the more important. De-ethylation of the phosphate moiety has not been observed.
Metabolism
The principal degradation route of isoxathion in animals, plants, and soil is cleavage of PO-isoxazole through oxidative desulfuration to the oxon followed by hydrolysis to 3-hydroxy-5-phenylisoxazole, which is conjugated in both plants and rats.
Degradation
Isoxathion is unstable to alkalis (PM). The hydrolysis product, 3-hydroxy- 5-phenylisoxazole (2), yielded 5-phenyl-3H-oxazolin-2-one (3) as the major photoproduct via a photolytic rearrangement (Nakagawa et al.,1974).
Toxicity evaluation
The acute oral LD50 for rats is 112 mg/kg. NOEL (2 yr) for rats is 1.2 mg/kg b.w. DT50 in soil is 9–40 d.
ISOXATHION Preparation Products And Raw materials
Raw materials
Preparation Products
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