2-CHLORO-3-IODOPYRIDIN-4-AMINE

Product Name: 2-CHLORO-3-IODOPYRIDIN-4-AMINE
CAS No.: 909036-46-0
Chemical Name: 2-CHLORO-3-IODOPYRIDIN-4-AMINE
Synonyms: 2-Chloro-3-iodo-4-pyridinamine;2-Chloro-3-iodo-4-aminopyridine;oro-3-iodopyridin-4-amine;2-CHLORO-3-IODOPYRIDIN-4-AMINE;2-Chloro-3-iodo-4-pyridylamine;4-Amino-2-chloro-3-iodopyridine;2-CHL0R0-3-I0D0PYRIDIN-4- AMINE;4-PyridinaMine, 2-chloro-3-iodo-;4-Amino-2-chloro-3-iodopyridine,95%
CBNumber: CB81229280
Molecular Formula: C5H4ClIN2
Formula Weight: 254.46
MOL File: 909036-46-0.mol

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2-CHLORO-3-IODOPYRIDIN-4-AMINE Property

Melting point:: 116-117℃
Boiling point:: 377.0±42.0 °C(Predicted)
Density: 2.139±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: 2.96±0.42(Predicted)
form: Solid
color: White to pink/orange
Sensitive: Light Sensitive
InChI: InChI=1S/C5H4ClIN2/c6-5-4(7)3(8)1-2-9-5/h1-2H,(H2,8,9)
InChIKey: BYVMKCHHWASQFN-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=CC(N)=C1I

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22
HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H301Toxic if swalloed

H302Harmful if swallowed

H311Toxic in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: ADE000415
Product name: 2-Chloro-3-iodopyridin-4-amine
Purity: Aldrich
Packaging: 1g
Price: $497
Updated: 2025/07/31

TRC

Product number: C367543
Product name: 2-Chloro-3-iodopyridin-4-amine
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Ark Pharm

Product number: AK-45676
Product name: 2-Chloro-3-iodopyridin-4-amine
Purity: 98%
Packaging: 1g
Price: $31
Updated: 2021/12/16

Matrix Scientific

Product number: 026193
Product name: 2-Chloro-3-iodopyridin-4-amine
Purity: 97%
Packaging: 500mg
Price: $44
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC138852
Product name: 2-Chloro-3-iodopyridin-4-amine
Packaging: 250mg
Price: $65
Updated: 2021/12/16

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2-CHLORO-3-IODOPYRIDIN-4-AMINE Chemical Properties,Usage,Production

Uses

2-Chloro-3-iodo-4-pyridinamine can be used as a useful synthetic intermediate.

Synthesis

14432-12-3

909036-46-0

General procedure for the synthesis of 2-chloro-3-iodo-4-pyridinamine from 2-chloro-4-aminopyridine: To a 50 mL single-necked round-bottomed flask equipped with a magnetic stir bar, a reflux condenser tube, and a nitrogen inlet tube under nitrogen protection were added 2-chloro-4-aminopyridine (2.50 g, 19.4 mmol, 1.0 equiv.), sodium sulfate trihydrate (3.97 g, 29.2 mmol, 1.5 equiv.), iodine monochloride (3.47 g, 21.4 mmol, 1.1 equiv.) and glacial acetic acid (13.0 mL). 1.5 equiv), iodine monochloride (3.47 g, 21.4 mmol, 1.1 equiv) and glacial acetic acid (13.0 mL). The reaction mixture was heated at 70 °C and magnetically stirred for 16 hours. Complete consumption of the feedstock was confirmed by thin layer chromatography (TLC) and electron bombardment mass spectrometry (GC/MS-EI) analysis. Upon completion of the reaction, the mixture was cooled to room temperature and transferred to a dispensing funnel. Solid sodium bicarbonate (32.3 g) was carefully added in batches to quench the reaction, followed by water (75 mL) and ethyl acetate (75 mL). After complete release of the gas produced, the layers were left to stratify. The aqueous layer was separated and extracted with ethyl acetate (6 x 25 mL). All organic layers were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to remove the solvent. The residue was purified by silica gel column chromatography with hexane/ethyl acetate as eluent (94:6 to 60:40 gradient elution) to afford 2-chloro-3-iodopyridin-4-amine as a light brown solid (2.21 g, 45% yield). The 1H NMR spectrum and low-resolution GC/MS (EI) mass spectrometry data of the product were consistent with those reported in the literature.

References

[1] European Journal of Medicinal Chemistry, 2017, vol. 128, p. 202 - 212
[2] Patent: EP2526945, 2012, A1. Location in patent: Page/Page column 63
[3] Patent: WO2013/10880, 2013, A1. Location in patent: Page/Page column 94
[4] Patent: EP2548876, 2013, A1. Location in patent: Paragraph 0368; 0369
[5] Patent: WO2014/207260, 2014, A1. Location in patent: Page/Page column 78

2-CHLORO-3-IODOPYRIDIN-4-AMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CHLORO-3-IODOPYRIDIN-4-AMINE Suppliers

China 157 Germany 1 India 11 United Kingdom 3 United States 11 Global 183

Jinan Liheng Biotechnology Co., Ltd.

Tel: 0531-18763987518 18763987518
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Ningbo Zhenyue Pharmaceutical Technology Co., Ltd

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Shanghai Jian Chao Chemical Technology Co., Ltd.

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J & K SCIENTIFIC LTD.

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Energy Chemical

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Shijiazhuang Sdyano Fine Chemical Co., Ltd.

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Wuhan Chemwish Technology Co., Ltd

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Shanghai Ennopharm Co., Ltd.

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View Lastest Price from 2-CHLORO-3-IODOPYRIDIN-4-AMINE manufacturers

Henan Fengda Chemical Co., Ltd

Product: 2-Chloro-3-iodo-4-pyridinamine 909036-46-0
Price: US $200.00-1.00/KG
Min. Order: 1KG
Purity: 99%, 99.5% Sublimated
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-31

Career Henan Chemical Co

Product: 2-CHLORO-3-IODOPYRIDIN-4-AMINE 909036-46-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2019-08-07

909036-46-0, 2-CHLORO-3-IODOPYRIDIN-4-AMINERelated Search:

Closantel 3-Iodo-4-aminopyridine 2-Chloro-3-iodopyridine 2-CHLORO-3-IODOPYRIDIN-4-AMINE

2-CHLORO-3-IODOPYRIDIN-4-AMINE

2-Chloro-3-iodo-4-aminopyridine

4-Amino-2-chloro-3-iodopyridine

4-PyridinaMine, 2-chloro-3-iodo-

2-Chloro-3-iodo-4-pyridinamine

oro-3-iodopyridin-4-amine

4-Amino-2-chloro-3-iodopyridine,95%

2-CHL0R0-3-I0D0PYRIDIN-4- AMINE

2-Chloro-3-iodo-4-pyridylamine

909036-46-0