1,2,4-Triazine Property

Boiling point:

197℃

Density 

1.173

refractive index 

1.5060 (estimate)

Flash point:

92℃

storage temp. 

2-8°C

solubility 

Chloroform (Slightly, Heated, Sonicated), DMSO (Slightly, Heated, Sonicated)

form 

Gel

pka

0.98±0.63(Predicted)

color 

Very Dark Orange to Very Dark Brown

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

1,2,4-Triazine Chemical Properties,Usage,Production

Description

1,2,4-Triazine is an electron-deficient heteroaromatic azadiene capable of participation in inverse electron demand Diels-Alder reactions with electron-rich dienophiles.

Uses

1,2,4-Triazine (>90%) is used in improvements of pesticide formulations with lactamides. 1,2,4-triazines scaffold-valuable lead molecules possess diverse pharmacological activities, easy synthetic routes for synthesis and attracted researchers for development of new chemotherapeutic agents in human and mouse model.

Definition

ChEBI: 1,2,4-triazine is a triazine and a member of 1,2,4-triazines.

Synthesis

1,2,4-Triazine is prepared by a cooled (-75 °C) solution of monomeric Glyoxal (90.0 mmol) in absolute MeOH (200 mL) is added to a solution of formamidrazone hydrochloride (40 mmol) in absolute MeOH (300 mL) at -50 °C. Et3N (200 mmol) is added and the resulting reaction mixture is allowed to stand at 25 °C for 24 h. The MeOH is removed in vacuo at 20 °C and the residue extracted with Et2O (peroxide free, 5×). Vacuum distillation of the residue after evaporation of the Et2O affords 1,2,4-triazine (bp 25-28 °C/0.5 mmHg).

storage

Best stored at 0 °C or below. It is stable to acid, less stable to base, and is hygroscopic; should be stored under anhydrous conditions since it reacts slowly with water and protic solvents.