3-CHLORO-5-METHOXY-BENZOIC ACID
- Product Name
- 3-CHLORO-5-METHOXY-BENZOIC ACID
- CAS No.
- 82477-67-6
- Chemical Name
- 3-CHLORO-5-METHOXY-BENZOIC ACID
- Synonyms
- Benzoicacid,3-chloro-5-Methoxy;3-CHLORO-5-METHOXY-BENZOIC ACID;3-Chloro-5-methoxybenzoic acid 97%;3-Chloro-5-methoxy-benzoic acid≥ 97% (GC);3-Carboxy-5-chloroanisole, 5-Chloro-m-anisic acid
- CBNumber
- CB8125132
- Molecular Formula
- C8H7ClO3
- Formula Weight
- 186.59
- MOL File
- 82477-67-6.mol
3-CHLORO-5-METHOXY-BENZOIC ACID Property
- Melting point:
- 172-176 °C
- Boiling point:
- 323.1±22.0 °C(Predicted)
- Density
- 1.352±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- form
- powder
- pka
- 3.71±0.10(Predicted)
- color
- Off white (hint of dark cream & peach)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36/37
- RIDADR
- UN 2811 6.1/PG 3
- WGK Germany
- 3
- HazardClass
- 6.1
- PackingGroup
- Ⅲ
- HS Code
- 29163990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 696374
- Product name
- 3-Chloro-5-methoxybenzoic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $70.4
- Updated
- 2023/06/20
- Product number
- 696374
- Product name
- 3-Chloro-5-methoxybenzoic acid
- Purity
- 97%
- Packaging
- 5g
- Price
- $145
- Updated
- 2023/06/20
- Product number
- C367513
- Product name
- 3-Chloro-5-methoxybenzoic acid
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- C367513
- Product name
- 3-Chloro-5-methoxybenzoic acid
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- C367513
- Product name
- 3-Chloro-5-methoxybenzoic acid
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
3-CHLORO-5-METHOXY-BENZOIC ACID Chemical Properties,Usage,Production
Chemical Properties
White powder
Uses
3-chloro-5-methoxybenzoic acid
Synthesis
124-38-9
33719-74-3
82477-67-6
The general procedure for the synthesis of 3-chloro-5-methoxybenzoic acid from carbon dioxide and 3,5-dichloroanisole is as follows: the magnesium scraps (Fluka purum used for the Grignard reaction) are first pre-treated: the scraps are placed in a glass sintered funnel, 0.1 M hydrochloric acid is added and stirred with a glass rod for a few seconds, followed by a wash with three parts water to remove the acid. Finally, the magnesium chips were washed with two parts of acetone and bottled. Next, RedAl (1 g, 70% wt. of toluene solution) was added to dry tetrahydrofuran (100 mL, 99.95%) for drying. Pretreated magnesium shavings (5 g, 200 mmol) were placed in a round-bottomed flask and rinsed three times with nitrogen. 3,5-Dichloroanisole (26 g, 146 mmol) was dissolved in dry tetrahydrofuran (100 mL) and dibromoethane (1.8 g, 10 mmol) was added. The reaction mixture was flushed with nitrogen and refluxed for 2 hours. The heating was stopped and dry ice (10 g) was added in batches over 2 min. After all the dry ice was dissolved, the reaction mixture was poured into ice containing 2 M hydrochloric acid (400 mL). Post-treatment by ether (300 mL) extraction resulted in 11.2 g of 3-chloro-5-methoxybenzoic acid, 60.2 mmol in 41% yield.1H-NMR (500 MHz; acetone-d6): δ 7.57 (m, 1H), 7.49 (m, 1H), 7.23 (m, 1H), 3.91 (s, 3H).
References
[1] Patent: WO2003/101956, 2003, A1. Location in patent: Page 55
[2] Journal of Medicinal Chemistry, 1984, vol. 27, # 5, p. 577 - 585
3-CHLORO-5-METHOXY-BENZOIC ACID Preparation Products And Raw materials
Raw materials
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View Lastest Price from 3-CHLORO-5-METHOXY-BENZOIC ACID manufacturers
- Product
- 3-CHLORO-5-METHOXY-BENZOIC ACID 82477-67-6
- Price
- US $6.68/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2020-01-08