Toxoflavin

Product Name: Toxoflavin
CAS No.: 84-82-2
Chemical Name: Toxoflavin
Synonyms: Nsc 67078;Toxoflavin;PKF118-310;Brn 0021014;Toxoflavine;Toxinflavin;Xanthothricin;Toxoflavin (PKF118-310);1-MethylreuMycin, PKF118-310, Xanthrothricin;1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7-dione
CBNumber: CB81252947
Molecular Formula: C7H7N5O2
Formula Weight: 193.16
MOL File: 84-82-2.mol

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Toxoflavin Property

Melting point:: 165 °C
Boiling point:: 276.7±23.0 °C(Predicted)
Density: 1.65±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: H2O: soluble10mg/mL, clear
form: powder
pka: -2.71±0.20(Predicted)
color: white to light brown

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Safety

Hazard Codes: T
Risk Statements: 28
Safety Statements: 45-46
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3
Toxicity: LD50 in mice (mg/kg): 1.7 i.v.; 8.4 orally (Machlowitz)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: K4394
Product name: PKF118-310
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $96.6
Updated: 2024/03/01

Sigma-Aldrich

Product number: K4394
Product name: PKF118-310
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $646
Updated: 2024/03/01

Cayman Chemical

Product number: 22440
Product name: PKF118-310
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 22440
Product name: PKF118-310
Purity: ≥98%
Packaging: 5mg
Price: $135
Updated: 2024/03/01

Cayman Chemical

Product number: 22440
Product name: PKF118-310
Purity: ≥98%
Packaging: 10mg
Price: $254
Updated: 2024/03/01

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Toxoflavin Chemical Properties,Usage,Production

Uses

Toxoflavin is a distinctive yellow pigment produced by some species of Pseudomonas and Streptomyces. Toxoflavin is one of two toxins produced when a fermented coconut drink, Tempe bonkrek, is contaminated with P. cocovenenans. Toxoflavin (PKF 118-310) is a potent antagonist of Tcf4/b-catenin signalling, inhibiting the expression of survivin and inducing apoptosis in several tumour cell lines.

Uses

PKF118-310 is an inhibitor of survivin expression and antagonist of Tcf4/b-catenin signaling.

Definition

ChEBI: Toxoflavin is a pyrimidotriazine that is 1,6-dimethyl-1,5,6,7-tetrahydropyrimido[5,4-e][1,2,4]triazine with oxo groups at positions 5 and 7. It has a role as an antineoplastic agent, a toxin, a Wnt signalling inhibitor, an apoptosis inducer, a bacterial metabolite, an antibacterial agent and a virulence factor. It is a pyrimidotriazine and a carbonyl compound. It is functionally related to a reumycin.

Biochem/physiol Actions

PKF118-310 is an antagonist of the Tcf4/b-catenin signaling. The compound disrupts the Tcf4/b-catenin complex and inhibits expression of Tcf4 responsive genes. PKF118-310 inhibits expression of survivin and induces apoptosis in HCC, colon tumor and lymphocytic leukemia cell lines.

Toxoflavin Preparation Products And Raw materials

Raw materials

Preparation Products

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Toxoflavin Suppliers

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View Lastest Price from Toxoflavin manufacturers

Career Henan Chemical Co

Product: Toxoflavin 84-82-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 97%-99.9%
Supply Ability: 100kg
Release date: 2019-12-26

84-82-2, ToxoflavinRelated Search:

Canthaxanthin Toxoflavin reumycin

Toxoflavin

1,6-Dimethyl-5,7-dioxo-1,5,6,7-tetrahydropyrimido[5,4-e]-as-triazine

1,6-Dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione

Xanthothricin

1,6-Dimethyl-5,7-dioxo-1,5,6,7-tetrahydropyrimido(5,4-E)-as-triazine-5,7(1H,6H)-dione

1,6-Dimethylpyrimido(5,4-E)-as-triazine-5,7(1H,6H)-dione

Brn 0021014

Nsc 67078

Pyrimido(5,4-E)-1,2,4-triazine-5,7-(1H,6H)-dione, 1,6-dimethyl- (9ci)

Pyrimido(5,4-E)-as-triazine-5,7-(1H,6H)-dione, 1,6-dimethyl-

1-MethylreuMycin, PKF118-310, Xanthrothricin

Toxoflavine

PKF118-310

Toxoflavin (PKF118-310)

Pyrimido[5,4-e]-1,2,4-triazine-5,7(1H,6H)-dione, 1,6-dimethyl-

Toxinflavin

1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7-dione

β-catenin,Toxoflavin,Inhibitor,inhibit,Antibiotic,Bacterial,Beta catenin

84-82-2