ChemicalBook > CAS DataBase List > Toxoflavin

Toxoflavin

Product Name
Toxoflavin
CAS No.
84-82-2
Chemical Name
Toxoflavin
Synonyms
Nsc 67078;Toxoflavin;PKF118-310;Brn 0021014;Toxoflavine;Toxinflavin;Xanthothricin;Toxoflavin in Methanol;Toxoflavin (PKF118-310);Toxoflavin, 10 mM in DMSO
CBNumber
CB81252947
Molecular Formula
C7H7N5O2
Formula Weight
193.16
MOL File
84-82-2.mol
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Toxoflavin Property

Melting point:
165 °C
Boiling point:
276.7±23.0 °C(Predicted)
Density 
1.65±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
H2O: soluble10mg/mL, clear
form 
powder
pka
-2.71±0.20(Predicted)
color 
white to light brown
Water Solubility 
H2O: 10mg/mL, clear
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Safety

Hazard Codes 
T
Risk Statements 
28
Safety Statements 
45-46
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
Toxicity
LD50 in mice (mg/kg): 1.7 i.v.; 8.4 orally (Machlowitz)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
K4394
Product name
PKF118-310
Purity
≥98% (HPLC)
Packaging
5mg
Price
$96.6
Updated
2024/03/01
Sigma-Aldrich
Product number
K4394
Product name
PKF118-310
Purity
≥98% (HPLC)
Packaging
25mg
Price
$646
Updated
2024/03/01
Cayman Chemical
Product number
22440
Product name
PKF118-310
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
22440
Product name
PKF118-310
Purity
≥98%
Packaging
5mg
Price
$135
Updated
2024/03/01
Cayman Chemical
Product number
22440
Product name
PKF118-310
Purity
≥98%
Packaging
10mg
Price
$254
Updated
2024/03/01
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Toxoflavin Chemical Properties,Usage,Production

Uses

Toxoflavin is a distinctive yellow pigment produced by some species of Pseudomonas and Streptomyces. Toxoflavin is one of two toxins produced when a fermented coconut drink, Tempe bonkrek, is contaminated with P. cocovenenans. Toxoflavin (PKF 118-310) is a potent antagonist of Tcf4/b-catenin signalling, inhibiting the expression of survivin and inducing apoptosis in several tumour cell lines.

Uses

PKF118-310 is an inhibitor of survivin expression and antagonist of Tcf4/b-catenin signaling.

Definition

ChEBI: Toxoflavin is a pyrimidotriazine that is 1,6-dimethyl-1,5,6,7-tetrahydropyrimido[5,4-e][1,2,4]triazine with oxo groups at positions 5 and 7. It has a role as an antineoplastic agent, a toxin, a Wnt signalling inhibitor, an apoptosis inducer, a bacterial metabolite, an antibacterial agent and a virulence factor. It is a pyrimidotriazine and a carbonyl compound. It is functionally related to a reumycin.

Biochem/physiol Actions

PKF118-310 is an antagonist of the Tcf4/b-catenin signaling. The compound disrupts the Tcf4/b-catenin complex and inhibits expression of Tcf4 responsive genes. PKF118-310 inhibits expression of survivin and induces apoptosis in HCC, colon tumor and lymphocytic leukemia cell lines.

Toxoflavin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Toxoflavin manufacturers

Career Henan Chemical Co
Product
Toxoflavin 84-82-2
Price
US $1.00/KG
Min. Order
1KG
Purity
97%-99.9%
Supply Ability
100kg
Release date
2019-12-26

84-82-2, ToxoflavinRelated Search:

Canthaxanthin Toxoflavin reumycin AFLATOXIN B1 Emodin

  • Toxoflavin
  • 1,6-Dimethyl-5,7-dioxo-1,5,6,7-tetrahydropyrimido[5,4-e]-as-triazine
  • 1,6-Dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
  • Xanthothricin
  • 1,6-Dimethyl-5,7-dioxo-1,5,6,7-tetrahydropyrimido(5,4-E)-as-triazine-5,7(1H,6H)-dione
  • 1,6-Dimethylpyrimido(5,4-E)-as-triazine-5,7(1H,6H)-dione
  • Brn 0021014
  • Nsc 67078
  • Pyrimido(5,4-E)-1,2,4-triazine-5,7-(1H,6H)-dione, 1,6-dimethyl- (9ci)
  • Pyrimido(5,4-E)-as-triazine-5,7-(1H,6H)-dione, 1,6-dimethyl-
  • 1-MethylreuMycin, PKF118-310, Xanthrothricin
  • Toxoflavine
  • PKF118-310
  • Toxoflavin (PKF118-310)
  • Pyrimido[5,4-e]-1,2,4-triazine-5,7(1H,6H)-dione, 1,6-dimethyl-
  • Toxinflavin
  • 1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7-dione
  • β-catenin,Toxoflavin,Inhibitor,inhibit,Antibiotic,Bacterial,Beta catenin
  • Toxoflavin in Methanol
  • Toxoflavin, 10 mM in DMSO
  • 84-82-2