Toxoflavin Property

Melting point:

165 °C

Boiling point:

276.7±23.0 °C(Predicted)

Density 

1.65±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

H2O: soluble10mg/mL, clear

form 

powder

pka

-2.71±0.20(Predicted)

color 

white to light brown

Water Solubility 

H2O: 10mg/mL, clear

Safety

Hazard Codes 

T

Risk Statements 

28

Safety Statements 

45-46

RIDADR 

UN 2811 6.1 / PGIII

WGK Germany 

3

Toxicity

LD50 in mice (mg/kg): 1.7 i.v.; 8.4 orally (Machlowitz)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

Toxoflavin Chemical Properties,Usage,Production

Uses

Toxoflavin is a distinctive yellow pigment produced by some species of Pseudomonas and Streptomyces. Toxoflavin is one of two toxins produced when a fermented coconut drink, Tempe bonkrek, is contaminated with P. cocovenenans. Toxoflavin (PKF 118-310) is a potent antagonist of Tcf4/b-catenin signalling, inhibiting the expression of survivin and inducing apoptosis in several tumour cell lines.

Uses

PKF118-310 is an inhibitor of survivin expression and antagonist of Tcf4/b-catenin signaling.

Definition

ChEBI: Toxoflavin is a pyrimidotriazine that is 1,6-dimethyl-1,5,6,7-tetrahydropyrimido[5,4-e][1,2,4]triazine with oxo groups at positions 5 and 7. It has a role as an antineoplastic agent, a toxin, a Wnt signalling inhibitor, an apoptosis inducer, a bacterial metabolite, an antibacterial agent and a virulence factor. It is a pyrimidotriazine and a carbonyl compound. It is functionally related to a reumycin.

Biochem/physiol Actions

PKF118-310 is an antagonist of the Tcf4/b-catenin signaling. The compound disrupts the Tcf4/b-catenin complex and inhibits expression of Tcf4 responsive genes. PKF118-310 inhibits expression of survivin and induces apoptosis in HCC, colon tumor and lymphocytic leukemia cell lines.