ChemicalBook > CAS DataBase List > (R)-(+)-2-(TERT-BUTOXYCARBONYLAMINO)-3-PHENYLPROPANAL

(R)-(+)-2-(TERT-BUTOXYCARBONYLAMINO)-3-PHENYLPROPANAL

Product Name
(R)-(+)-2-(TERT-BUTOXYCARBONYLAMINO)-3-PHENYLPROPANAL
CAS No.
77119-85-8
Chemical Name
(R)-(+)-2-(TERT-BUTOXYCARBONYLAMINO)-3-PHENYLPROPANAL
Synonyms
Boc-D-Phe-aldehyde;BOC-D-PHENYLALANINAL;N-BOC-D-PHENYLALANINAL;N-T-BOC-D-PHENYLALANINAL;N-Boc-D-phenylalaninal 97%;N-BOC-D-Phenylalaninal,97%;N-Boc-2(R)-3-phenylpropanal;N-Boc-D-phenylalaninal;N-(tert-Butoxycarbonyl)-D-phenylalaninal;(R)-(+)-2-(tert-butoxycarbonylamino)-3-phenylprop
CBNumber
CB8126917
Molecular Formula
C14H19NO3
Formula Weight
249.31
MOL File
77119-85-8.mol
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(R)-(+)-2-(TERT-BUTOXYCARBONYLAMINO)-3-PHENYLPROPANAL Property

Melting point:
86-89 °C (lit.)
storage temp. 
-20°C
form 
Crystalline Powder
color 
White or tan
optical activity
[α]20/D +45°, c = 0.5 in methanol
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Safety

WGK Germany 
3
HS Code 
29223900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
469289
Product name
N-Boc-D-phenylalaninal
Purity
97%
Packaging
1g
Price
$172
Updated
2022/05/15
Biosynth Carbosynth
Product number
FB50585
Product name
Boc-D-phenylalaninal
Packaging
1g
Price
$200
Updated
2021/12/16
AK Scientific
Product number
X5488
Product name
N-Boc-D-phenylalaninal
Packaging
1g
Price
$203
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB50585
Product name
Boc-D-phenylalaninal
Packaging
250mg
Price
$80
Updated
2021/12/16
SynQuest Laboratories
Product number
4156-1-R0
Product name
N-Boc-D-Phenylalaninal
Purity
95%
Packaging
250mg
Price
$93
Updated
2021/12/16
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(R)-(+)-2-(TERT-BUTOXYCARBONYLAMINO)-3-PHENYLPROPANAL Chemical Properties,Usage,Production

Chemical Properties

White or tan crystalline powder

Uses

Boc-D-phenylalaninal is a useful research chemical compound used as a reactant in the copper(I)-catalyzed synthesis of 1,2,3-triazoles as inhibitors of human immunodeficiency virus type 1 protease.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

19901-50-9

77119-85-8

A toluene solution of DIBAL-H (1.0 M, 179 mL, 179 mmol) was added slowly and dropwise to a toluene-DCM (4:1, 1000 mL) solution of Compound 31c (25.0 g, 90 mmol) under stirring at -78 °C. The reaction was carried out under argon protection, followed by slow warming to room temperature and continuous stirring at this temperature for 1 hour. Immediately after completion of the reaction, methanol (200 mL) was added to quench the reaction. The reaction mixture was poured into 200 mL of 20% aqueous sodium potassium tartrate (Rochelle salt) and stirred at room temperature until the two phases were clearly separated. The organic layer was separated, concentrated under vacuum and the residue was purified by column chromatography (eluent: hexane/ethyl acetate = 2:1) to afford the target product compound 31d as a white solid (19.9 g, 89% yield).

References

[1] Patent: WO2011/107248, 2011, A1. Location in patent: Page/Page column 68; 69
[2] Journal of Medicinal Chemistry, 1993, vol. 36, # 2, p. 211 - 220
[3] Heterocycles, 1998, vol. 48, # 7, p. 1331 - 1335
[4] The Journal of organic chemistry, 2002, vol. 67, # 17, p. 6162 - 6173
[5] Journal of the Chemical Society - Perkin Transactions 1, 1999, # 20, p. 2983 - 2996

(R)-(+)-2-(TERT-BUTOXYCARBONYLAMINO)-3-PHENYLPROPANAL Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-(+)-2-(TERT-BUTOXYCARBONYLAMINO)-3-PHENYLPROPANAL Suppliers

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View Lastest Price from (R)-(+)-2-(TERT-BUTOXYCARBONYLAMINO)-3-PHENYLPROPANAL manufacturers

Career Henan Chemical Co
Product
(R)-(+)-2-(TERT-BUTOXYCARBONYLAMINO)-3-PHENYLPROPANAL 77119-85-8
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-10

77119-85-8, (R)-(+)-2-(TERT-BUTOXYCARBONYLAMINO)-3-PHENYLPROPANALRelated Search:

(S)-(-)-2-(TERT-BUTOXYCARBONYLAMINO)-3-PHENYLPROPANAL N-BOC-L-Prolinal BOC-ARG-OH BOC-L-NORLEUCINE BOC-D-ABU-OH BOC-D-MEPHE-OH DCHA BOC-D-Phenylalanine Boc-3-(2-Naphthyl)-D-alanine BOC-D-PHENYLALANINE 4-NITROPHENYL ESTER BOC-D-4-Fluorophe (S)-N-Boc-1-Naphthylalanine N-tert-Butyloxycarbonyl-O-(2-bromobenzyloxycarbonyl)-D-tyrosine BOC-D-4-Chlorophe BOC-D-TYR(ET)-OH BOC-D-4-Nitrophe BOC-D-TYR(BZL)-OH Boc-D-Tyr-OH BOC-D-4-IODOPHENYLALANINE

  • BOC-D-PHENYLALANINAL
  • N-T-BOC-D-PHENYLALANINAL
  • N-BOC-D-PHENYLALANINAL
  • (R)-(+)-2-(TERT-BUTOXYCARBONYLAMINO)-3-PHENYLPROPANAL
  • (R)-(+)-2-(tert-butoxycarbonylamino)-3-phenylprop
  • N-BOC-D-Phenylalaninal,97%
  • N-Boc-D-phenylalaninal 97%
  • tert-butyl(R)-(1-oxo-3-phenylpropan-2-yl)carbamate
  • N-Boc-2(R)-3-phenylpropanal
  • tert-butyl N-[(2R)-1-oxo-3-phenylpropan-2- yl]carbaMate
  • tert-Butyl-[(2R)-1-oxo-3-phenylpropan-2-yl]carbaMat
  • N-[(2R)-1-oxo-3-phenylpropan-2-yl]carbamic acid tert-butyl ester
  • N-(tert-Butoxycarbonyl)-D-phenylalaninal
  • Carbamic acid, N-[(1R)-1-formyl-2-phenylethyl]-, 1,1-dimethylethyl ester
  • Boc-D-Phe-aldehyde
  • <i>N</i>-Boc-<sc>D</sc>-phenylalaninal
  • (R)-tert-Butyl (1-oxo-3-phenylpropan-2-yl)carbamate - [B91283]
  • 77119-85-8
  • C6H5CH2CHNHCO2CCH33CHO
  • Amino Acid Derivatives
  • Amino Aldehydes
  • ALDEHYDE
  • Peptide Synthesis
  • Specialty Synthesis