ChemicalBook > CAS DataBase List > YM 09538

YM 09538

Product Name
YM 09538
CAS No.
70958-86-0
Chemical Name
YM 09538
Synonyms
Rowgan;Lowgan;YM 09538;AMOSULALOLHYOROCHLORIDE;5-[1-Hydroxy-2-[[2-(2-methoxyphenoxy)ethyl]amino]ethyl]-2-methyl-benzenesulfonamide monohydrochloride;Benzenesulfonamide, 5-[1-hydroxy-2-[[2-(2-methoxyphenoxy)ethyl]amino]ethyl]-2-methyl-, monohydrochloride
CBNumber
CB81270237
Molecular Formula
C18H24N2O5S.HCl
Formula Weight
0
MOL File
70958-86-0.mol
More
Less

YM 09538 Property

Melting point:
158-160℃
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

TRC
Product number
A634195
Product name
AmosulalolHydrochloride
Packaging
5mg
Price
$1320
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0001466
Product name
AMOSULALOL HYDROCHLORIDE
Purity
95.00%
Packaging
100MG
Price
$1127.86
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0001466
Product name
AMOSULALOL HYDROCHLORIDE
Purity
95.00%
Packaging
1G
Price
$2355.15
Updated
2021/12/16
Crysdot
Product number
CD12040785
Product name
5-(1-Hydroxy-2-((2-(2-methoxyphenoxy)ethyl)amino)ethyl)-2-methylbenzenesulfonamidehydrochloride
Purity
95+%
Packaging
1g
Price
$1488
Updated
2021/12/16
More
Less

YM 09538 Chemical Properties,Usage,Production

Originator

Amosulalol hydrochloride,Yamanouchi

Uses

Amosulalol Hydrochloride is used in studies to evaluate the effect of α1-blocker doxazosin on diabetic nephropathy -comparison with α,β -blockers.

Definition

ChEBI: Amosulalol hydrochloride is a sulfonamide.

Manufacturing Process

A mixture of N-benzyl-2-(2-methoxyphenoxy)ethylamine, methyl ethyl ketone, and 5-bromoacetyl-2-methylbenzenesulfonamide was refluxed with stirring. After cooling the reaction mixture, ethyl ketone was distilled off under reduced pressure and the residue formed was dissolved in benzene. Then, ether was added to the solution and after removing the hydrobromide of N-benzyl-2-(2- methoxyphenoxy)ethylamine precipitated, the solvent was distilled off under reduced pressure to provide a viscous oily product.
The viscous oily product was dissolved in ethanol and after adding to the solution an excess amount of sodium borohydride, the mixture was stirred at room temperature followed by distilling off ethanol under reduced pressure. The residue was dissolved in ethyl acetate and the ethyl acetate layer recovered was washed with water, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to provide a viscous oily product. The product was subjected to a silica gel column chromatography and eluted using benzene and then a mixture of benzene and ethyl acetate of 10:1 by volume ratio to provide 5-{1-hydroxy-2-[N-benzyl-2-(2- methoxyphenoxy)ethylamino]ethyl}-2-methyl-benzenesulfonamide as a viscous oily product.
In 200 ml of methanol was dissolved 20.0 g of 5-{1-hydroxy-2-[N-benzyl-2- (2-methoxyphenoxy)ethylamino]ethyl}-2-methyl-benzenesulfonamide. After adding thereto 20 ml of ethanol containing about 10% hydrogen chloride and 1.0 g of 10% palladium charcoal, the mixture was shaken in hydrogen gas stream. When the absorption of hydrogen stopped, the catalyst was filtered away and the filtrate was distilled off under reduced pressure. The residue was dissolved in 100 ml of ethanol while it was hot and the solution was allowed to stand overnight in ice chamber, whereby 12.8 g of the α-type crystals of 5-{1-hydroxy-2-[2-(2-methoxyphenoxy)ethylamino]ethyl}-2- methylbenzenesulfonamide were obtained as the colorless crystals, melting point 169°-171°C.
In practice it is usually used as monohydrochloride

Therapeutic Function

Alpha-adrenergic blocker, Beta-adrenergic blocker, Antihypertensive

YM 09538 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

70958-86-0, YM 09538Related Search:


  • Benzenesulfonamide, 5-[1-hydroxy-2-[[2-(2-methoxyphenoxy)ethyl]amino]ethyl]-2-methyl-, monohydrochloride
  • Lowgan
  • YM 09538
  • AMOSULALOLHYOROCHLORIDE
  • 5-[1-Hydroxy-2-[[2-(2-methoxyphenoxy)ethyl]amino]ethyl]-2-methyl-benzenesulfonamide monohydrochloride
  • Rowgan
  • 70958-86-0
  • C18H24N2O5SHCl