Enclomiphene
- Product Name
- Enclomiphene
- CAS No.
- 15690-57-0
- Chemical Name
- Enclomiphene
- Synonyms
- enclomiphene;Enclomifene;EncloMiphene-d4;trans-2-(4-(2-chloro-1,2-diphenylethenyl)phenoxy)-n,n-diethylethanamine;ici46476;RMI 16,289;(E)-Clomiphene;trans-clomifene;E-CloMiphene-d4;trans-clomiphene
- CBNumber
- CB8128416
- Molecular Formula
- C26H28ClNO
- Formula Weight
- 405.96
- MOL File
- 15690-57-0.mol
Enclomiphene Property
- Melting point:
- 149.0-150.5°
- Boiling point:
- 509.0±50.0 °C(Predicted)
- Density
- 1.104±0.06 g/cm3(Predicted)
- pka
- 9.60±0.25(Predicted)
N-Bromosuccinimide Price
- Product number
- C587015
- Product name
- trans-Clomiphene
- Packaging
- 2.5mg
- Price
- $195
- Updated
- 2021/12/16
- Product number
- C587015
- Product name
- trans-Clomiphene
- Packaging
- 25mg
- Price
- $1540
- Updated
- 2021/12/16
- Product number
- API0005680
- Product name
- ETHANAMINE, 2-[4-[(1E)-2-CHLORO-1,2-DIPHENYLETHENYL]PHENOXY]-N,N-DIETHYL
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $498.83
- Updated
- 2021/12/16
Enclomiphene Chemical Properties,Usage,Production
Description
Enclomiphene is a synthetic and nonsteroidal antiestrogen. It is the more potent isomer and the one responsible for its ovulation-inducing actions. The half-life of enclomiphene is relatively short, so serum concentrations rise and fall quickly during and after treatment. Antiestrogens represent the first-line treatment strategy in WHO class-2 anovulatory infertility.
Uses
trans-Clomiphene is a Clomiphene (C587025) stereoisomer, a synthetic estrogen agonist-antagonist. Gonad-stimulating principle. Treatment for infertility.
Definition
ChEBI: Clomiphene is a tertiary amine. It has a role as an estrogen antagonist and an estrogen receptor modulator. It derives from a hydride of a stilbene.
Preparation
CONDENSATION OF 4-HYDROXYBENZOPHENONE WITH 2-(DIETHYLAMINO)ETHYL CHLORIDE FOLLOWED BY TREATMENT WITH BENZYL MAGNESIUM CHLORIDE AND DEHYDRATION TO GIVE 2-(P-(1,2-DIPHENYLVINYL)PHENOXY)TRIETHYLAMINE WHICH IS CHLORINATED AND TREATED WITH CITRIC ACID /CITRATE/
Biological Activity
Enclomiphene is the trans-isomer of clomiphene citrate (CC). It has a higher rate of clearance and is less active than the cis-isomer, cis-clomiphene. Clomiphene citrate has been evaluated for antineoplastic activity against breast cancer.
Mode of action
Enclomiphene is a non-steroidal estrogen receptor antagonist that promotes gonadotropin-dependent testosterone secretion by the testes. The main mechanism of its action is thought to be its antagonistic effects on the hypothalamic-pituitary axis and stimulation of GnRH secretion.
References
[1] SIMON HILL Richard Q Vijayaraman Arutchelvam. Enclomiphene, an estrogen receptor antagonist for the treatment of testosterone deficiency in men.[J]. Idrugs, 2009, 12 2: 109-119.
[2] KATHERINE M RODRIGUEZ Larry I L Alexander W Pastuszak. Enclomiphene citrate for the treatment of secondary male hypogonadism.[J]. Expert Opinion on Pharmacotherapy, 2016, 17 11: 1561-1567. DOI:10.1080/14656566.2016.1204294.
[3] JOSHUA A EARL Edward D K. Enclomiphene citrate: A treatment that maintains fertility in men with secondary hypogonadism.[J]. Expert Review of Endocrinology & Metabolism, 2019, 14 3: 157-165. DOI:10.1080/17446651.2019.1612239.
Enclomiphene Preparation Products And Raw materials
Raw materials
Preparation Products
Enclomiphene Suppliers
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View Lastest Price from Enclomiphene manufacturers
- Product
- Enclomiphene 15690-57-0
- Price
- US $250.00-2000.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 10kg
- Release date
- 2023-03-30
- Product
- Enclomiphene 15690-57-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99.9%
- Supply Ability
- 20tons
- Release date
- 2023-09-05
- Product
- TRANS-CLOMIPHENE HCL 15690-57-0
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99% HPLC
- Supply Ability
- 20 tons
- Release date
- 2023-03-09