Enclomiphene

ChemicalBook > CAS DataBase List > Enclomiphene

Product Name: Enclomiphene
CAS No.: 15690-57-0
Chemical Name: Enclomiphene
Synonyms: enclomiphene;Enclomifene;EncloMiphene-d4;trans-2-(4-(2-chloro-1,2-diphenylethenyl)phenoxy)-n,n-diethylethanamine;ici46476;RMI 16,289;(E)-Clomiphene;trans-clomifene;E-CloMiphene-d4;trans-clomiphene
CBNumber: CB8128416
Molecular Formula: C26H28ClNO
Formula Weight: 405.96
MOL File: 15690-57-0.mol

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Enclomiphene Property

Melting point:: 149.0-150.5°
Boiling point:: 509.0±50.0 °C(Predicted)
Density: 1.104±0.06 g/cm3(Predicted)
pka: 9.60±0.25(Predicted)
InChI: InChI=1S/C26H28ClNO/c1-3-28(4-2)19-20-29-24-17-15-22(16-18-24)25(21-11-7-5-8-12-21)26(27)23-13-9-6-10-14-23/h5-18H,3-4,19-20H2,1-2H3/b26-25+
InChIKey: GKIRPKYJQBWNGO-OCEACIFDSA-N
SMILES: C(N(CC)CC)COC1=CC=C(/C(/C2=CC=CC=C2)=C(/Cl)\C2=CC=CC=C2)C=C1

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: C587015
Product name: trans-Clomiphene
Packaging: 2.5mg
Price: $195
Updated: 2021/12/16

TRC

Product number: C587015
Product name: trans-Clomiphene
Packaging: 25mg
Price: $1540
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0005680
Product name: ETHANAMINE, 2-[4-[(1E)-2-CHLORO-1,2-DIPHENYLETHENYL]PHENOXY]-N,N-DIETHYL
Purity: 95.00%
Packaging: 5MG
Price: $498.83
Updated: 2021/12/16

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Enclomiphene Chemical Properties,Usage,Production

Description

Enclomiphene is a synthetic and nonsteroidal antiestrogen. It is the more potent isomer and the one responsible for its ovulation-inducing actions. The half-life of enclomiphene is relatively short, so serum concentrations rise and fall quickly during and after treatment. Antiestrogens represent the first-line treatment strategy in WHO class-2 anovulatory infertility.

Uses

trans-Clomiphene is a Clomiphene (C587025) stereoisomer, a synthetic estrogen agonist-antagonist. Gonad-stimulating principle. Treatment for infertility.

Definition

ChEBI: Clomiphene is a tertiary amine. It has a role as an estrogen antagonist and an estrogen receptor modulator. It derives from a hydride of a stilbene.

Preparation

CONDENSATION OF 4-HYDROXYBENZOPHENONE WITH 2-(DIETHYLAMINO)ETHYL CHLORIDE FOLLOWED BY TREATMENT WITH BENZYL MAGNESIUM CHLORIDE AND DEHYDRATION TO GIVE 2-(P-(1,2-DIPHENYLVINYL)PHENOXY)TRIETHYLAMINE WHICH IS CHLORINATED AND TREATED WITH CITRIC ACID /CITRATE/

Biological Activity

Enclomiphene is the trans-isomer of clomiphene citrate (CC). It has a higher rate of clearance and is less active than the cis-isomer, cis-clomiphene. Clomiphene citrate has been evaluated for antineoplastic activity against breast cancer.

Mode of action

Enclomiphene is a non-steroidal estrogen receptor antagonist that promotes gonadotropin-dependent testosterone secretion by the testes. The main mechanism of its action is thought to be its antagonistic effects on the hypothalamic-pituitary axis and stimulation of GnRH secretion.

References

[1] SIMON HILL Richard Q Vijayaraman Arutchelvam. Enclomiphene, an estrogen receptor antagonist for the treatment of testosterone deficiency in men.[J]. Idrugs, 2009, 12 2: 109-119.
[2] KATHERINE M RODRIGUEZ Larry I L Alexander W Pastuszak. Enclomiphene citrate for the treatment of secondary male hypogonadism.[J]. Expert Opinion on Pharmacotherapy, 2016, 17 11: 1561-1567. DOI:10.1080/14656566.2016.1204294.
[3] JOSHUA A EARL Edward D K. Enclomiphene citrate: A treatment that maintains fertility in men with secondary hypogonadism.[J]. Expert Review of Endocrinology & Metabolism, 2019, 14 3: 157-165. DOI:10.1080/17446651.2019.1612239.

Enclomiphene Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Enclomiphene manufacturers

Shandong Huizhihan Supply Chain Co., Ltd

Product: Androxal(Enclomiphene) 25mg Tablets 15690-57-0
Price: US $0.00-0.00/Bottle
Min. Order: 1Bottle
Purity: 99%
Supply Ability: 2000
Release date: 2024-11-05

Shaanxi Xianhe Biotech Co., Ltd

Product: Enclomiphene 15690-57-0
Price: US $1.00/kg
Min. Order: 0.1kg
Purity: 0.99
Supply Ability: 1000 kg
Release date: 2024-12-17

American HealthyMorph LLC

Product: Enclomiphene 15690-57-0
Price: US $0.00/Box
Min. Order: 1Box
Purity: 99%
Supply Ability: 1000/week
Release date: 2024-12-18

15690-57-0, EnclomipheneRelated Search:

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2-diphenylvinyl)phenoxy)-2-(p-(2-chloro-(e)-triethylamin

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ici46476

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Androxal(Enclomiphene) 25mg Tablets

15690-57-0