DICHLORPHENAMIDE
- Product Name
- DICHLORPHENAMIDE
- CAS No.
- 120-97-8
- Chemical Name
- DICHLORPHENAMIDE
- Synonyms
- cb8000;CB 8000;Glaucor;Oralcon;glaucol;Oratrol;Dalanide;daramide;Daranide;Dasanide
- CBNumber
- CB8129776
- Molecular Formula
- C6H6Cl2N2O4S2
- Formula Weight
- 305.16
- MOL File
- 120-97-8.mol
DICHLORPHENAMIDE Property
- Melting point:
- 239-241° (patent, mp 228.5-229°)
- Boiling point:
- 590.5±60.0 °C(Predicted)
- Density
- 1.7263 (rough estimate)
- refractive index
- 1.6000 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Acetonitrile (Slightly), Chloroform, DMSO (Slightly), Methanol
- form
- Solid
- pka
- pKa 7.4 (Uncertain);8.6 (Uncertain)
- color
- White to Off-White
- CAS DataBase Reference
- 120-97-8(CAS DataBase Reference)
- NIST Chemistry Reference
- 4,5-Dichloro-m-benzenedisulfonamide(120-97-8)
- EPA Substance Registry System
- 1,3-Benzenedisulfonamide, 4,5-dichloro- (120-97-8)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 63
- Safety Statements
- 36
- RTECS
- CZ9200000
- HS Code
- 2935904000
- Hazardous Substances Data
- 120-97-8(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H361Suspected of damaging fertility or the unborn child
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P281Use personal protective equipment as required.
P308+P313IF exposed or concerned: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 1188006
- Product name
- Dichlorphenamide
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 200mg
- Price
- $436
- Updated
- 2024/03/01
- Product number
- 23658
- Product name
- Dichlorphenamide
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 23658
- Product name
- Dichlorphenamide
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $70
- Updated
- 2024/03/01
- Product number
- 23658
- Product name
- Dichlorphenamide
- Packaging
- 25mg
- Price
- $118
- Updated
- 2024/03/01
- Product number
- 23658
- Product name
- Dichlorphenamide
- Packaging
- 50mg
- Price
- $172
- Updated
- 2024/03/01
DICHLORPHENAMIDE Chemical Properties,Usage,Production
Chemical Properties
Off-White Solid
Originator
Daranide,MSD ,US,1958
Uses
Like the drugs described above, dichlorphenamide is used for secreting excess water in cases of elevated intraocular pressure, and it is used for treating wide-angle and secondary glaucoma as well as in cases where it is necessary to lower intraocular pressure before surgical intervention in severe wide-angle glaucoma.
Uses
Diclofenamide is a potent carbonic anhydrase inhibitor. Diclofenamide may provide a therapeutic strategy in the inhibition of the human cytosolic isoforms I and II and transmembrane tumor-associated isoenzymes IX and XII. Diclofenamide has been shown to be is effective in the prevention of episodic weakness in both hypokalemic periodic paralysis (HypoPP) and potassium-sensitive periodic paralysis (PSPP).
Definition
ChEBI: A sulfonamide that is benzene-1,3-disulfonamide in which the hydrogens at positions 4 and 5 are substituted by chlorine. An oral carbonic anhydrase inhibitor, it partially suppresses the secretion (inflow) of aqueous humor in the eye and so reduces intraoc lar pressure. It is used for the treatment of glaucoma.
Manufacturing Process
In a 2 liter round-bottomed flask equipped with stirrer and dropping funnel is
placed 1,585 grams (880 cc; 13.6 mols) of chlorosulfonic acid. To this is
added dropwise with stirring during 5 hours 218 grams (1.7 mols) of ochlorophenol. The mixture is allowed to stand 1 hour at room temperature
and then is heated 1 hour on a steam bath. The mixture is then poured on
ice.
A product consisting largely of 5-chloro-4-hydroxybenzene-1,3-disulfonyl
chloride separates as a gum which solidifies on standing for about 1 hour. The
solid product is collected on a Buchner funnel, washed with water and
thoroughly dried in air at room temperature.
A mixture of this crude product (approximately 302 grams, 0.92 mol) and 480
grams (2.3 mols) of phosphorus pentachloride is heated for 1 hour at 120°-
140°C in a 2 liter round-bottomed flask. The resulting clear solution is poured
on ice. 4,5-Dichlorobenzene-1,3-disulfonyl chloride separates immediately as a
solid. It is collected by filtration and washed with water. While still moist, it is
added in portions during about 20 minutes to 1 liter of concentrated ammonia
water contained in a 3 liter beaker surrounded by a cold water bath. The
reaction mixture is then allowed to stand for 1 hour without cooling after
which it is heated on a steam bath for about 30 minutes while air is bubbled
through it, in order to remove some of the excess ammonia. It is then
filtered, acidified with concentrated hydrochloric acid and chilled.
The product separates as a gum from which the supernatant liquid is
decanted, and the gum is triturated with 250 cc of water in order to induce
crystallization. The crude product thus obtained is recrystallized from 3,200 cc of boiling water and then from 40% aqueous isopropyl alcohol yielding 4,5-
dichlorobenzene-1,3-disulfonamide as a white solid, MP 228.5° to 229.0°C. of boiling water and then from 40% aqueous isopropyl alcohol yielding 4,5-
dichlorobenzene-1,3-disulfonamide as a white solid, MP 228.5° to 229.0°C.
brand name
Daranide (Merck).
Therapeutic Function
Carbonic anhydrase inhibitor, Antiglaucoma
Clinical Use
Dichlorphenamide is a disulfonamide derivative that shares the same pharmacological properties。The dose of dichlorphenamide is 25 to 100 mg one to three times a day.
Synthesis
Dichlorphenamide, 4,5-dichlorbenzol-1,3-disulfonamide (21.2.6), is made in a relatively simple way from 2-chlorophenol. 2-Chlorophenol undergoes sulfochlorination by chlorosulfonic acid, forming 4-hydroxy-5-chlorobenzol-1,3- disulfonylchloride (21.2.4). The hydroxyl group is replaced by a chlorine atom using phosphorous pentachloride, giving 4,5-dichlorobenzol-1,3-disulfonylchoride (21.2.5), the reaction of which with ammonia gives the desired dichlorphenamide (21.2.6).
Veterinary Drugs and Treatments
Dichlorphenamide is used for the medical treatment of glaucoma. Because of availability issues and toxic effects associated with systemic therapy, human (and many veterinary) ophthalmologists are using topical carbonic anhydrase inhibitors (e.g., dorzolamide or brinzolamide) in place of acetazolamide, dichlorphenamide or methazolamide.
DICHLORPHENAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from DICHLORPHENAMIDE manufacturers
- Product
- DICHLORPHENAMIDE 120-97-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-07-08
- Product
- DICHLORPHENAMIDE 120-97-8
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 200KG
- Release date
- 2020-01-07