ChemicalBook > CAS DataBase List > beta catenin
beta catenin
- Product Name
- beta catenin
- CAS No.
- 146409-33-8
- Chemical Name
- beta catenin
- Synonyms
- CTNB;CTNB1;CATNB;CTNNB;MRD19;CTNNB1;PRO2286;FLJ25606;FLJ37923;catenin β
- CBNumber
- CB81313789
- Formula Weight
- 0
- MOL File
- Mol file
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beta catenin Property
- storage temp.
- -70°C
- form
- buffered aqueous glycerol solution
- biological source
- human
- Water Solubility
- water: soluble
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Safety
- WGK Germany
- 1
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SRP5172
- Product name
- Catenin β, GST tagged human
- Purity
- recombinant, expressed in baculovirus infected <I>Sf</I>9 cells, ≥70% (SDS-PAGE), buffered aqu
- Packaging
- 50 μg
- Price
- $361
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- SRP5172
- Product name
- Catenin β, GST tagged human
- Purity
- recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
- Packaging
- 50μG
- Price
- $335
- Updated
- 2023/06/20
Sigma-Aldrich
- Product number
- SAB1306576
- Product name
- ANTI-CTNB1(C-TERMINAL) antibody produced in rabbit
- Purity
- affinity isolated antibody, buffered aqueous solution
- Packaging
- 400μL
- Price
- $461
- Updated
- 2023/01/07
Usbiological
- Product number
- 139640
- Product name
- CTNNB1
- Packaging
- 200ul
- Price
- $456
- Updated
- 2021/12/16
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beta catenin Chemical Properties,Usage,Production
Uses
Catenin β, GST tagged human has been used:
- as a component of protein kinase buffer for in vitro kinase assay
- in in vitro?citrullination assay to characterize β-catenin citrullination
- to perform differentiation factor screening
General Description
β-catenins are cytoplasmic proteins that are ubiquitously expressed. These proteins associate with E-cadherin at cellular junctions. CTNNB1 (catenin β-1) belongs to the armadillo family of proteins. This protein possesses a 130 amino acid N-terminal domain, 12 imperfect repeats of 42 amino acids termed arm repeats and a 100 amino acid C-terminal domain. The gene encoding β-catenin is localized on human chromosome 3p22.1.
Biochem/physiol Actions
β-catenin interacts with T-cell factor and lymphoid enhancer-binding factor (TCF and LEF) transcription factors and is an essential member of the Wingless-Wnt signal transduction pathway. The adenomatous polyposis coli (APC) tumor-suppressor protein, together with Axin and glycogen synthase kinase 3 β (GSK3β), form a Wnt-regulated signaling complex that mediates phosphorylation-dependent degradation of βcatenin by the proteasome. APC and the Siah-1 E3 ubiquitin-protein ligase-1 mediate a novel β-catenin degradation pathway linking p53 activation to cell cycle control. Activating mutations in the human β-catenin gene have been found in human colon cancer and melanomas. The protein has a role in homeostasis and development.
beta catenin Preparation Products And Raw materials
Raw materials
Preparation Products
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