1-(BROMOMETHYL)-4-(METHYLSULFONYL)BENZENE

Product Name: 1-(BROMOMETHYL)-4-(METHYLSULFONYL)BENZENE
CAS No.: 53606-06-7
Chemical Name: 1-(BROMOMETHYL)-4-(METHYLSULFONYL)BENZENE
Synonyms: 1-(Chloromethyl)-4-(methylsulfonyl)benzene;4-METHYLSULFONYLBENZYL BROMIDE;4-METHYLSULPHONYLBENZYL BROMIDE;4-(Methanesulfonyl)benzyl bromide;4-(Methylsulfonyl)benzylBromide>4-Methylsulphonylbenzyl bromide,85%;4-Methylsulphonylbenzyl bromide, tech.;4-(Methylsulphonyl)benzyl bromide 97%;1-(broMoMethyl)-4-Methanesulfonylbenzene;1-(BROMOMETHYL)-4-(METHYLSULFONYL)BENZENE
CBNumber: CB8132497
Molecular Formula: C8H9BrO2S
Formula Weight: 249.12
MOL File: 53606-06-7.mol

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1-(BROMOMETHYL)-4-(METHYLSULFONYL)BENZENE Property

Melting point:: 82-86 °C
Boiling point:: 375.2±34.0 °C(Predicted)
Density: 1.550
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: soluble in Methanol
form: Crystalline Powder
color: Beige to brown

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-36-22-34
Safety Statements: 37/39-26-45-36/37/39
RIDADR: UN3261
WGK Germany: 3
HazardClass: 8
PackingGroup: III
HS Code: 29049090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: VBP00037
Product name: 4-(Methylsulfonyl)benzyl bromide
Purity: Aldrich
Packaging: 1g
Price: $185
Updated: 2025/07/31

TCI Chemical

Product number: M2474
Product name: 4-(Methylsulfonyl)benzyl Bromide
Purity: >97.0%(GC)(T)
Packaging: 1g
Price: $79
Updated: 2025/07/31

TCI Chemical

Product number: M2474
Product name: 4-(Methylsulfonyl)benzyl Bromide
Purity: >97.0%(GC)(T)
Packaging: 5g
Price: $268
Updated: 2025/07/31

TRC

Product number: B697328
Product name: 1-(Bromomethyl)-4-methanesulfonylbenzene
Packaging: 1g
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB139841
Product name: 1-(Bromomethyl)-4-(methylsulfonyl)benzene
Packaging: 5G
Price: $175
Updated: 2021/12/16

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1-(BROMOMETHYL)-4-(METHYLSULFONYL)BENZENE Chemical Properties,Usage,Production

Chemical Properties

white to beige crystalline powder

Synthesis

22821-77-8

53606-06-7

The general procedure for the synthesis of 4-(methylsulfonyl)benzyl bromide from 4-methylsulfonylphenylmethanol was as follows: methanesulfonyl chloride (1.00 mL, 12.9 mmol) was added slowly and dropwise to a stirred solution of 4-(methylsulfonyl)phenylmethanol (2.00 g, 10.7 mmol) and triethylamine (2.24 mL, 16.1 mmol) in acetone (25 mL) at 0 °C. The reaction mixture was continued to be stirred at this temperature for 30 minutes. The reaction mixture was filtered and lithium bromide (4.66 g, 53.7 mmol) was added to the filtrate in three batches at 0 °C. The resulting mixture was stirred at 0 °C for 5 minutes and then gradually warmed up to room temperature and continued stirring for 1.5 hours. The reaction mixture was filtered again and the filtrate was concentrated under vacuum. After dilution with 50 mL of water, the product was extracted with dichloromethane (50 mL x 3). The organic phases were combined, dried over anhydrous sodium sulfate and concentrated under vacuum to give 1-(bromomethyl)-4-(methylsulfonyl)benzene (2.80 g, 100% yield) as a white solid.1H NMR (300 MHz, CDCl3) δppm: 7.95 (d, J=8.4 Hz, 2H), 7.61 (d, J=8.4 Hz, 2H), 4.53 (s, 2H), 3.08 (s, 3H).

References

[1] Patent: WO2017/136871, 2017, A1. Location in patent: Paragraph 0223
[2] Journal of the Chemical Society, 1962, p. 1420 - 1427
[3] Canadian Journal of Chemistry, 1984, vol. 62, p. 2330 - 2336
[4] Journal of Medicinal Chemistry, 1989, vol. 32, # 8, p. 1757 - 1763
[5] Journal of Organic Chemistry, 2011, vol. 76, # 20, p. 8203 - 8214

1-(BROMOMETHYL)-4-(METHYLSULFONYL)BENZENE Preparation Products And Raw materials

Raw materials

N-Bromosuccinimide 1-Methyl-4-(methylsulfonyl)-benzene Carbon tetrachloride

Preparation Products

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1-(BROMOMETHYL)-4-(METHYLSULFONYL)BENZENE Suppliers

Americas 1 Belgium 1 China 121 Europe 1 Germany 3 India 5 Japan 1 The Netherlands 1 United Kingdom 4 United States 15 Global 153

GLR Innovations

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TCI Chemicals (India) Pvt. Ltd.

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Alfa Aesar

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A.J Chemicals

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View Lastest Price from 1-(BROMOMETHYL)-4-(METHYLSULFONYL)BENZENE manufacturers

Wuhan Monad Medicine Tech Co.,LTD

Product: 4-(Methylsulfonyl)Benzyl Bromide 53606-06-7
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%min
Supply Ability: 20000
Release date: 2020-12-17

Shijiazhuang tongyang Import and Export Co., LTD

Product: 1-(BROMOMETHYL)-4-(METHYLSULFONYL)BENZENE 53606-06-7
Price: US $48.00/KG
Min. Order: 1g
Purity: 99.9%
Supply Ability: 500000kgs
Release date: 2021-08-11

Career Henan Chemical Co

Product: 1-(BROMOMETHYL)-4-(METHYLSULFONYL)BENZENE 53606-06-7
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-08

53606-06-7, 1-(BROMOMETHYL)-4-(METHYLSULFONYL)BENZENERelated Search:

SULBENICILLIN 4-BROMO-1-(BROMOMETHYL)-2-(METHYLSULFONYL)BENZENE 1-(bromomethyl)-2-(methylsulfonyl)benzene 4-CHLORO-N-CYCLOPROPYL-N-PIPERIDIN-4-YLBENZENESULFONAMIDE 2-(BROMOMETHYL)-1-CHLORO-5-(METHYLSULFONYL)-3-NITROBENZENE 1-(BROMOMETHYL)-4-(METHYLSULFONYL)BENZENE AKOS 91252 2-(bromomethyl)-1,3-dichloro-5-(methylsulfonyl)benzene 1-(bromomethyl)-4-[(4-methylphenyl)sulfonyl]benzene 1-(BROMOMETHYL)-4-[(DIFLUOROMETHYL)SULFONYL]BENZENE 1-(BROMOMETHYL)-4-(METHYLSULFONYL)-2-NITROBENZENE

1-(Bromomethyl)-4-(methylsulfonyl)benzene [tech.]

4-Methylsulphonylbenzyl broMide, tech. 2.5GR

4-(Methanesulfonyl)benzyl bromide

1-(broMoMethyl)-4-Methanesulfonylbenzene

1-(Bromomethyl)-4-(methylsulphonyl)benzene, 4-(Bromomethyl)phenyl methyl sulphone

4-(Methanesulfonyl)benzyl bromide 1-(Bromomethyl)-4-(methylsulfonyl)benzene

1-(Chloromethyl)-4-(methylsulfonyl)benzene

1-(BROMOMETHYL)-4-(METHYLSULFONYL)BENZENE

4-METHYLSULFONYLBENZYL BROMIDE

4-METHYLSULPHONYLBENZYL BROMIDE

4-Methylsulphonylbenzyl bromide, tech.

4-Methylsulphonylbenzyl bromide,85%

4-Methylsulphonylbenzyl bromide,75-80%,tech

4-(Methylsulphonyl)benzyl bromide 97%

4-(Methylsulfonyl)benzylBromide&gt

Benzene, 1-(bromomethyl)-4-(methylsulfonyl)-

53606-06-7

C8H9B2O2S

BENZYL HALIDE

Boron, Nitrile, Thio,& TM-Cpds

Halides