ChemicalBook > CAS DataBase List > handelin

handelin

Product Name: handelin
CAS No.: 62687-22-3
Chemical Name: handelin
Synonyms: handelin;Yejuhualactone;Handelin, 10 mM in DMSO;HANDELIN; YEJUHUALACTONE;6,6'-dihydroxy-6,6',9,9'-tetramethyl-3'-methylene-2,2'-dioxo-2',3a,3',3a',4,5,5',6,6a,6',7,9a,9b,9',9a',9b'-hexadecahydro-4'H-spiro[azuleno[4,5-b]furan-3,10'-[6a,9]ethanoazuleno[4,5-b]furan]-5-yl acetate;Spiro[azuleno[4,5-b]furan-3(2H),10'-[4H-6a,9]ethanoazuleno[4,5-b]furan]-2,2'(3'H)-dione, 4-(acetyloxy)-3a,3'a,4,5,5',6,6',6a,7,9',9a,9'a,9b,9'b-tetradecahydro-6,6'-dihydroxy-6,6',9,9'-tetramethyl-3'-methylene-, (3R,3aR,3'aS,4S,6R,6'R,6aR,6'aR,9'R,9aR,9'aS,9bR,9'bS)-
CBNumber: CB81326400
Molecular Formula: C32H40O8
Formula Weight: 552.66
MOL File: 62687-22-3.mol

Less

handelin Property

Boiling point:: 731.0±60.0 °C(Predicted)
Density: 1.34±0.1 g/cm3 (20 ºC 760 Torr)
pka: 14.34±0.70(Predicted)
form: Solid
color: White to off-white
InChIKey: SZQWAXGDCUONOB-GZFIRXSHNA-N

Less

Hazard and Precautionary Statements (GHS)

Less

N-Bromosuccinimide Price

Usbiological

Product number: 300396
Product name: Handelin
Packaging: 20mg
Price: $665
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb259571
Product name: Handelin
Purity: 98%
Packaging: 10mg
Price: $499.8
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PXT0004138
Product name: HANDELIN
Purity: 95.00%
Packaging: 5MG
Price: $502.14
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb259571
Product name: Handelin
Purity: 98%
Packaging: 20mg
Price: $634.1
Updated: 2021/12/16

ChemScene

Product number: CS-0018588
Product name: Handelin
Purity: 99.44%
Packaging: 5mg
Price: $269
Updated: 2021/12/16

Less

handelin Chemical Properties,Usage,Production

Chemical Properties

White powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from wild chrysanthemum.

Uses

Handelin is a guaianolide dimer from Chrysanthemum boreale that has potent anti-inflammatory activity by down-regulating NF-κB signaling and pro-inflammatory cytokine production[1].

Definition

ChEBI: Handelin is a sesterterpenoid.

in vivo

Handelin (Compound 1; 10-20 mg/kg; oral administration; for 30 mintues; male Sprague-Dawley rats) treatment inhibits acute inflammation in carrageenan-induced paw edema model. The serum level of IL-1β is also inhibited by Handelin in a carrageenan-induced paw edema model ^[1].

Animal Model:	Male Sprague-Dawley (SD) rats (150-170 g, 5 weeks old) injected with carrageenan^[1]
Dosage:	10 mg/kg, 20 mg/kg
Administration:	Oral administration; for 30 mintues
Result:	Inhibited acute inflammation in carrageenan-induced paw. The serum level of IL-1β was also inhibited.

References

[1] Y Pyee, et al. Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production. J Nat Prod. 2014 Apr 25;77(4):917-24. DOI:10.1021/np4009877

handelin Preparation Products And Raw materials

Raw materials

Preparation Products

Less

handelin Suppliers

CHINA 103 United States 7 Global 110

Chengdu Biopurify Ltd.

Tel: 28-82633860 18982077548
Email: cwb1@biopurify.cn
Country: China
ProdList: 3842
Advantage: 58

Chengdu Biopurify Phytochemicals Ltd.

Tel: +86-028-82633397 18982077548
Fax: +86-28-82633165
Email: cwb1@biopurify.cn
Country: China
ProdList: 2376
Advantage: 60

Chengdu Climax Biotech Co., Ltd.

Tel: 028-83311324 1278112614
Fax: 028-83311324
Email: climaxbiotech@gmail.com
Country: China
ProdList: 925
Advantage: 58

Shanghai Winherb Medical Technology Co., Ltd.

Tel: 021-38218169 13341702378
Fax: QQ：190129269
Email: winherb@126.com
Country: China
ProdList: 1245
Advantage: 58

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12335
Advantage: 58

Shanghai Tauto Biotech Co., Ltd.

Tel: 021-51320588
Fax: 0086-21-51320502
Email: tauto@tautobiotech.com
Country: China
ProdList: 3988
Advantage: 66

Chengdu Herbpurify Co.Ltd.

Tel: 2355253622; 18981954830
Fax: 086-28-85377358
Email: 2355253622@qq.com;
Country: China
ProdList: 1103
Advantage: 58

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7778
Advantage: 56

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15178
Advantage: 58

Shanghai Yongye Biotechnology Co., Ltd.

Tel: 86-021-61559134 15921386130
Fax: 021-55068248
Email: 3423497944@qq.com
Country: China
ProdList: 8144
Advantage: 55

Wuhan ChemFaces Biochemical Co., Ltd.

Tel: 18607101326 15172504745
Fax: +86-27-84254680
Email: aileen@chemfaces.com
Country: China
ProdList: 6905
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Shanghai ChengShao Biological Technology Co., Ltd.

Tel: 021-61847300 13341622919
Fax: 021-61847300
Email: shcss01@163.com
Country: China
ProdList: 4808
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
Advantage: 58

Shanghai Uteam Biotechnology Co., Ltd.

Tel: 021-36031160 13311776681
Email: 3338195766@QQ.com
Country: China
ProdList: 5093
Advantage: 55

Shanghai Biological Technology Development Co., Ltd.

Tel: 021-69955236-807 13918189704
Fax: 021-65211385
Email: chinaruji@chinaruji.com
Country: China
ProdList: 5095
Advantage: 55

Chengdu Push Bio-Technology Co., Ltd.

Tel: 028-028-85370565-229-229 18080489829
Email: 18080489829@163.com
Country: China
ProdList: 8250
Advantage: 60

Chengdu Alfa Biotechnology Co.,Ltd.

Tel: 028-85142057, 18030712385
Fax: 028-85142057 QQ:3591697873
Email: sales@alfabiotech.com
Country: China
ProdList: 1925
Advantage: 58

Chengdu Greenpure Biopharma CO.,Ltd

Tel: 028-88203606; 18283602253
Email: jancyzheng@gcgreenpure.com
Country: China
ProdList: 1594
Advantage: 58

Shanghai Standard Technology Co.,Ltd.

Tel: 021-021-57127007-6622-6622 17621252073
Fax: +86 (21) 5132-0077
Email: luzh@nature-standard.com
Country: China
ProdList: 3021
Advantage: 58

Shanghai Innovative Reseach Center Of Traditional

Tel: 86-21-50801717-301
Fax: 86-21-50800509
Email: wangjh@sirc-tcm.sh.cn
Country: China
ProdList: 2070
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Beijing OKA biological technology co., LTD

Tel: 010-62971590 18548936886
Fax: 010-62340519
Email: 3462612863@qq.com
Country: China
ProdList: 10063
Advantage: 58

Nanjing Yuanzhi Biotechnology Co. Ltd.

Tel: 15805159960
Email: 1211550495@qq.com
Country: China
ProdList: 1796
Advantage: 58

Nanjing Dasf Biotechnology Co., Ltd.

Tel: 025-025-+86-02585846866 +86-18094231287
Fax: 025-83144123
Email: 1773155960@qq.com
Country: China
ProdList: 1992
Advantage: 58

ANHUI WITOP BIOTECH CO., LTD

Tel: +8615255079626
Email: eric@witopchemical.com
Country: China
ProdList: 23541
Advantage: 58

Wuhan ChemNorm Biotech Co.,Ltd.

Tel: +86-27-8439 4403 18971486879
Fax: +86-27-8439 4403
Email: sales@chemnorm.com
Country: CHINA
ProdList: 2935
Advantage: 58

Hubei Jusheng Technology Co.,Ltd.

Tel: 18871490254
Fax: 027-59599243
Email: linda@hubeijusheng.com
Country: CHINA
ProdList: 28172
Advantage: 58

Shanghai jingkang bioengineering co., ltd.

Tel: 021-54721350 13524668266
Fax: 021-5
Email: 2881505714@qq.com
Country: China
ProdList: 7872
Advantage: 58

career henan chemical co

Tel: +86-0371-86658258 +8613203830695
Fax: 0086-371-86658258
Email: factory@coreychem.com
Country: China
ProdList: 29798
Advantage: 58

Absin Bioscience Inc.

Tel: 021-38015121 18438616290
Email: lanwu@univ-bio.com
Country: China
ProdList: 24731
Advantage: 58

PCL - Business, Laboratory Pharmaceutical

Tel: 19150123681
Fax: QQ:3008022628
Email: Hu.xinyue@purechemland.com
Country: China
ProdList: 3566
Advantage: 58

Shanghai Fusheng Industrial Co., LTD

Tel: 021-52961053 13524666654
Email: 3004902811@qq.com
Country: China
ProdList: 9724
Advantage: 58

Chengdu PFID reference Technology Co., Ltd

Tel: 028-82610909 15882229804
Email: pufeide@foxmail.com
Country: China
ProdList: 2335
Advantage: 58

Shanghai Sig Biotechnology Co., LTD

Tel: 021-57810052 18930344717
Fax: 021-57810052
Email: 2089316240@qq.com
Country: China
ProdList: 9395
Advantage: 58

Wuxi Helen Biotechnology Co., Ltd.,

Tel: 0510-85629785 18013409632
Fax: 0510-85625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 14081
Advantage: 58

Wuhan ChemNorm co., LTD.

Tel: 18971486879
Email: 279414929@qq.com
Country: CHINA
ProdList: 2925
Advantage: 58

Shanghai Hewu Biotechnology Co., LTD

Tel: 021-57886085 17317861055
Email: shhebio@126.com
Country: CHINA
ProdList: 7974
Advantage: 58

Guizhou Dida Technology Co., Ltd

Tel: 0851-8475-2296 18096062265
Fax: 0851-84752205
Email: 646585516@qq.com
Country: China
ProdList: 2778
Advantage: 58

Guangzhou Yunmen Biotechnology Co., Ltd

Tel: 0751-18902340975/189023400307 18902340307
Fax: 0751-2819901
Email: 3356812514@qq.com
Country: China
ProdList: 9249
Advantage: 58

Foshan Treasure Biotechnology Co., Ltd

Tel: 0757-85921206 18520245316
Email: 2329783215@qq.com
Country: China
ProdList: 12661
Advantage: 58

Shanghai Taopu Industrial Co., LTD

Tel: 159-00573766 18018507602
Email: 394643792@qq.com
Country: China
ProdList: 4328
Advantage: 58

Shanghai Moqi Biological Technology Co., LTD

Tel: 021-38218169 13681877033
Email: 2702713455@qq.com
Country: China
ProdList: 9997
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Shanghai klamar Reagent Co., LTD

Tel: 4001650900 13817534909
Email: 3003940895@qq.com
Country: China
ProdList: 10714
Advantage: 58

Naturewill Biotechnology Co., Ltd.

Tel: 028-82632533 18113192475
Email: 3157321941@qq.com
Country: China
ProdList: 4993
Advantage: 58

Chengdu RefMedic Biotech Co Ltd

Tel: 028-82253651 18140204969
Email: sales@refmedic.com
Country: China
ProdList: 2260
Advantage: 58

Shandong Mopai Biotechnology Co., Ltd

Tel: 13053322091
Email: admin@mopaikeji.com
Country: China
ProdList: 5830
Advantage: 58

Shanghai Yanchun Biopharmaceutical Technology Co., Ltd

Tel: 4001-009266 17349750668
Email: product@sci-e.com
Country: China
ProdList: 2808
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: rose.shi@synzest.com
Country: China
ProdList: 6210
Advantage: 58

Less

View Lastest Price from handelin manufacturers

Career Henan Chemical Co

Product: handelin 62687-22-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%HPLC
Supply Ability: 10 tons
Release date: 2020-01-09

62687-22-3, handelinRelated Search:

Apigenin Polycaprolactone 10-isobutyryloxy-8,9-epoxythymol isobutyrate TRIBULOSIDE Linarin Acitretin medicagenic acid 8,9-epoxyl-3-isobutyryloxy-10-(2-methylbutanoyl)thymol Robinin Brassinolide (2alpha,3beta,19alpha)-2,3,19-Trihydroxyolean-12-en-28-oic acid beta-D-glucopyranosyl ester 1α-(β-D-Glucopyranosyloxy)-1,4a,5,6,7,7aα-hexahydro-4aα-hydroxy-7α-methyl-5-oxocyclopenta[c]pyran-4-carboxylic acid methyl ester Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside 8-epidiosbulbin E acetate

HANDELIN; YEJUHUALACTONE

handelin

Yejuhualactone

6,6'-dihydroxy-6,6',9,9'-tetramethyl-3'-methylene-2,2'-dioxo-2',3a,3',3a',4,5,5',6,6a,6',7,9a,9b,9',9a',9b'-hexadecahydro-4'H-spiro[azuleno[4,5-b]furan-3,10'-[6a,9]ethanoazuleno[4,5-b]furan]-5-yl acetate

Spiro[azuleno[4,5-b]furan-3(2H),10'-[4H-6a,9]ethanoazuleno[4,5-b]furan]-2,2'(3'H)-dione, 4-(acetyloxy)-3a,3'a,4,5,5',6,6',6a,7,9',9a,9'a,9b,9'b-tetradecahydro-6,6'-dihydroxy-6,6',9,9'-tetramethyl-3'-methylene-, (3R,3aR,3'aS,4S,6R,6'R,6aR,6'aR,9'R,9aR,9'aS,9bR,9'bS)-

Handelin, 10 mM in DMSO

62687-22-3