Binodenoson

Product Name: Binodenoson
CAS No.: 144348-08-3
Chemical Name: Binodenoson
Synonyms: SHA 211;SHA 174;MRE 0470;WRC 0470;Binodisine;BINODENOSON;Binodenoson/MRE-0470;Binodenoson, 10 mM in DMSO;2-(cyclohexylmethylidenehydrazino)adenos;2-(cyclohexylmethylidenehydrazino)adenosine
CBNumber: CB81343021
Molecular Formula: C17H25N7O4
Formula Weight: 391.42
MOL File: 144348-08-3.mol

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Binodenoson Property

Melting point:: 154-157°
Boiling point:: 765.6±70.0 °C(Predicted)
Density: 1.76
storage temp.: Store at -20°C
solubility: DMSO : 125 mg/mL (319.35 mM; Need ultrasonic)
pka: 6.92±0.70(Predicted)
form: Solid
color: White to off-white
InChIKey: XJFMHMFFBSOEPR-XNIJJKJLSA-N
SMILES: OC[C@H]1O[C@@H](N2C3C(=C(N=C(NN=CC4CCCCC4)N=3)N)N=C2)[C@H](O)[C@@H]1O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P330Rinse mouth.

P501Dispose of contents/container to..…

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Binodenoson Chemical Properties,Usage,Production

Description

Binodenoson, 2-[(cyclohexylmethylene)hydrazino] adenosine (MRE0470), is being developed as a short-acting coronary vasodilator, administered intravenously, as an adjunct to radiotracers in myocardial stress imaging techniques to detect the presence and severity of CAD in patients unable to exercise. The compound is a highly selective agonist at the adenosine A2A receptor and also has a weaker affinity for adenosine A1-, A2B-, and A3-receptor subtypes than adenosine[1].

Uses

2-(cyclohexylmethylidenehydrazino)adenosine is used in the diagnosis of coronary heart disease (adenosine A2A agonist).

Pharmacokinetics

The mean values for the apparent elimination half-life of binodenoson ranged from 7.4 minutes (at 1 g/kg) to 14.9 minutes (6 g/kg), with a slight tendency toward higher values with increasing doses. However, because the plasma concentrations for the lowest dose level (0.4 g/kg) were only marginally higher than the assay's lower limit of quantitation, the plasma concentrations could be determined for a longer period of time at the higher dose levels. On average (harmonic mean), the terminal half-life of binodenoson across all doses was 10±4 minutes[1].

in vitro

Binodenoson (MRE-0470) (30-300 nM) decreases oxidative activity of tumor necrosis factor-α–primed FMLP-stimulated polymorphonuclear leukocytes in human whole blood and acts synergistically with Rolipram.

in vivo

Binodenoson (infused 0-0.9 μg/kg/h; adult Wistar rat; rat bacterial meningitis model), with or without rolipram (0-0.01 μg/kg/h), inhibits pleocytosis and reduces the lipopolysaccharide-induced increase in blood-brain barrier permeability (BBBP), indicative of decreased neutrophil-induced damage.

References

[1] Richard J. Barrett PhD . “Pharmacokinetics and safety of binodenoson after intravenous dose escalation in healthy volunteers.” Journal of Nuclear Cardiology 12 2 (2005): Pages 166-171.

Binodenoson Preparation Products And Raw materials

Raw materials

Preparation Products

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Binodenoson Suppliers

China 28 Switzerland 1 United States 4 Global 33

T&W GROUP

Tel: 021-61551611 13296011611
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Email: contact@trustwe.com
Country: China
ProdList: 9895
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Zhengzhou Granlen Sciences, ltd.

Tel: 0371-85513397 +86-18610099868
Email: info@granlen.com
Country: China
ProdList: 1890
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32467
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NewCan Biotech Limited

Tel: +86-571-86912261 19975279805
Email: sales@newcanbio.com
Country: China
ProdList: 9985
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BOC Sciences

Tel: +1-631-485-4226
Fax: 1-631-614-7828
Email: inquiry@bocsci.com
Country: United States
ProdList: 19552
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CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49977
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SHANGHAI T&W PHARMACEUTICAL CO., LTD.

Tel: +86-021-61551413 +8618813727289
Email: contact@trustwe.com
Country: China
ProdList: 5742
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Wuhan Topule

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Wuhan Augda Biotechnology Co., Ltd

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Bide Pharmatech Ltd.

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Country: China
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144348-08-3, Binodenoson Related Search:

2,6-Diaminopurine 2,6-Diaminopurine 2'-deoxyriboside 2-AMINOADENOSINE 2-Aminopurine riboside Binodenoson 2(1H)-Pyrimidinone, hydrazone (9CI) 2-Hydrazinoadenosine

2-(cyclohexylmethylidenehydrazino)adenosine

(2R,3R,4R,5R)-2-[6-amino-2-((2E)-2-(cyclohexylmethylidene)hydrazinyl)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol

BINODENOSON

WRC 0470

2-[2-(Cyclohexylmethylene)hydrazinyl]adenosine

MRE 0470

SHA 174

SHA 211

Binodisine

Adenosine, 2-[2-(cyclohexylmethylene)hydrazinyl]-

2-(Cyclo hexyl methylidene hydrazino) adenosine, Binodenoson

2-(Cyclhexyl methylidene hydrazino) adenosine

2-(cyclohexylmethylidenehydrazino)adenos

MRE 0470,imaging,P1 receptor,stress,oxidative,WRC0470,neutrophil,inhibit,radiotracers,Binodenoson,Adenosine Receptor,Inhibitor,WRC-0470,MRE0470,myocardial

Binodenoson/MRE-0470

2-[(cyclohexylmethylene)hydrazino]-Adenosine

Binodenoson, 10 mM in DMSO

(2R,3R,4S,5R)-2-(6-Amino-2-(2-(cyclohexylmethylene)hydrazinyl)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

144348-08-3